Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction

Jinkwon Kim, Tae Jin Song, Dongbeom Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Jihoe Heo

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with cerebral atherosclerosis and prognosis in patients with acute stroke is not well known. METHODS - In 1034 patients with first-ever acute cerebral infarction, levels of ALP and phosphate were compared with (1) cerebral atherosclerosis and (2) poor long-term functional outcomes as defined by the modified Rankin Scale >2 at 3 months after stroke onset. RESULTS - ALP levels were not associated with cerebral atherosclerosis. However, higher levels of ALP were associated with a poor functional outcome (adjusted odds ratio per 1 SD, 1.25; 95% confidence interval, 1.04-1.50). Phosphate was associated with neither cerebral atherosclerosis nor functional outcome. CONCLUSIONS - A higher level of ALP was not associated with cerebral atherosclerosis but was an independent prognostic factor for long-term functional outcome after acute cerebral infarction.

Original languageEnglish
Pages (from-to)3547-3549
Number of pages3
JournalStroke
Volume44
Issue number12
DOIs
Publication statusPublished - 2013 Dec 1

Fingerprint

Intracranial Arteriosclerosis
Cerebral Infarction
Alkaline Phosphatase
Phosphates
Serum
Stroke
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

Cite this

Kim, Jinkwon ; Song, Tae Jin ; Song, Dongbeom ; Lee, Hye Sun ; Nam, Chung Mo ; Nam, Hyo Suk ; Kim, Young Dae ; Heo, Jihoe. / Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction. In: Stroke. 2013 ; Vol. 44, No. 12. pp. 3547-3549.
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abstract = "BACKGROUND AND PURPOSE - Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with cerebral atherosclerosis and prognosis in patients with acute stroke is not well known. METHODS - In 1034 patients with first-ever acute cerebral infarction, levels of ALP and phosphate were compared with (1) cerebral atherosclerosis and (2) poor long-term functional outcomes as defined by the modified Rankin Scale >2 at 3 months after stroke onset. RESULTS - ALP levels were not associated with cerebral atherosclerosis. However, higher levels of ALP were associated with a poor functional outcome (adjusted odds ratio per 1 SD, 1.25; 95{\%} confidence interval, 1.04-1.50). Phosphate was associated with neither cerebral atherosclerosis nor functional outcome. CONCLUSIONS - A higher level of ALP was not associated with cerebral atherosclerosis but was an independent prognostic factor for long-term functional outcome after acute cerebral infarction.",
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Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction. / Kim, Jinkwon; Song, Tae Jin; Song, Dongbeom; Lee, Hye Sun; Nam, Chung Mo; Nam, Hyo Suk; Kim, Young Dae; Heo, Jihoe.

In: Stroke, Vol. 44, No. 12, 01.12.2013, p. 3547-3549.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction

AU - Kim, Jinkwon

AU - Song, Tae Jin

AU - Song, Dongbeom

AU - Lee, Hye Sun

AU - Nam, Chung Mo

AU - Nam, Hyo Suk

AU - Kim, Young Dae

AU - Heo, Jihoe

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N2 - BACKGROUND AND PURPOSE - Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with cerebral atherosclerosis and prognosis in patients with acute stroke is not well known. METHODS - In 1034 patients with first-ever acute cerebral infarction, levels of ALP and phosphate were compared with (1) cerebral atherosclerosis and (2) poor long-term functional outcomes as defined by the modified Rankin Scale >2 at 3 months after stroke onset. RESULTS - ALP levels were not associated with cerebral atherosclerosis. However, higher levels of ALP were associated with a poor functional outcome (adjusted odds ratio per 1 SD, 1.25; 95% confidence interval, 1.04-1.50). Phosphate was associated with neither cerebral atherosclerosis nor functional outcome. CONCLUSIONS - A higher level of ALP was not associated with cerebral atherosclerosis but was an independent prognostic factor for long-term functional outcome after acute cerebral infarction.

AB - BACKGROUND AND PURPOSE - Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with cerebral atherosclerosis and prognosis in patients with acute stroke is not well known. METHODS - In 1034 patients with first-ever acute cerebral infarction, levels of ALP and phosphate were compared with (1) cerebral atherosclerosis and (2) poor long-term functional outcomes as defined by the modified Rankin Scale >2 at 3 months after stroke onset. RESULTS - ALP levels were not associated with cerebral atherosclerosis. However, higher levels of ALP were associated with a poor functional outcome (adjusted odds ratio per 1 SD, 1.25; 95% confidence interval, 1.04-1.50). Phosphate was associated with neither cerebral atherosclerosis nor functional outcome. CONCLUSIONS - A higher level of ALP was not associated with cerebral atherosclerosis but was an independent prognostic factor for long-term functional outcome after acute cerebral infarction.

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