Abstract
Objectives: We investigated the association between autoantibodies against non-myeloperoxidase (MPO) neutrophil granule antigens and activity of Behçet's disease (BD). Methods: We consecutively enrolled 51 BD patients. We assessed clinical data and BD activity using patients' index scores from the Behçet's Disease Current Activity Form and we performed tests for antibodies against proteinase 3 (PR3), MPO, bactericidal permeability increasing protein (BPI), cathepsin G, elastase, lactoferrin and lysozyme. Results: The median patient index score was 2.0, and 56.9% of patients had active BD. In multivariate analysis of variables with significant correlations, only anti-lysozyme showed a significant correlation with BD activity (P = 0.002). In multivariate logistic regression analyses of variables, when patients were classified into groups according to the optimal cutoff levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and anti-lysozyme (ESR > 42.5 mm/h, CRP > 1.35 mg/L and anti-lysozyme > 2.95 IU/mL), the variable with independent predictive value was anti-lysozyme (odds ratio 8.384, P = 0.015). Conclusion: Anti-lysozyme was significantly correlated with disease activity score and it was the only independent value to predict active disease in patients with BD. Furthermore, patients having anti-lysozyme levels ≥ 2.95 IU/mL had a significantly higher risk of having active BD than those who did not.
Original language | English |
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Pages (from-to) | 261-268 |
Number of pages | 8 |
Journal | International Journal of Rheumatic Diseases |
Volume | 20 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2017 Feb |
Bibliographical note
Funding Information:This study was supported by a faculty research grant from the Department of Internal Medicine, Yonsei University College of Medicine for 2012.
Publisher Copyright:
© 2016 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
All Science Journal Classification (ASJC) codes
- Rheumatology