Serum BAFF expression in patients with myasthenia gravis

Jee Young Kim, Young Yang, Joon Shik Moon, Eun Young Lee, Sun Hwha So, Hong Soo Lee, Kee Duk Park, Youngchul Choi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A B-cell activating factor of the tumor necrosis factor (TNF) family (BAFF) is an essential B-cell survival factor. Myasthenia gravis (MG) is one of the most typical antibody-mediated autoimmune disorders. To test whether serum BAFF levels are increased in MG patients, we compared the serum BAFF levels of 40 MG patients with those of 30 healthy controls. Serum BAFF levels of MG group were significantly higher than those of healthy group. These results suggested that the BAFF might play a role in the immunopathogenesis of MG and further study on B-cell and T-cell activation may be needed.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalJournal of Neuroimmunology
Volume199
Issue number1-2
DOIs
Publication statusPublished - 2008 Aug 13

Fingerprint

Myasthenia Gravis
Serum
B-Lymphocytes
B-Cell Activating Factor
Cell Survival
Tumor Necrosis Factor-alpha
T-Lymphocytes
Antibodies

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Kim, J. Y., Yang, Y., Moon, J. S., Lee, E. Y., So, S. H., Lee, H. S., ... Choi, Y. (2008). Serum BAFF expression in patients with myasthenia gravis. Journal of Neuroimmunology, 199(1-2), 151-154. https://doi.org/10.1016/j.jneuroim.2008.05.010
Kim, Jee Young ; Yang, Young ; Moon, Joon Shik ; Lee, Eun Young ; So, Sun Hwha ; Lee, Hong Soo ; Park, Kee Duk ; Choi, Youngchul. / Serum BAFF expression in patients with myasthenia gravis. In: Journal of Neuroimmunology. 2008 ; Vol. 199, No. 1-2. pp. 151-154.
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Kim, JY, Yang, Y, Moon, JS, Lee, EY, So, SH, Lee, HS, Park, KD & Choi, Y 2008, 'Serum BAFF expression in patients with myasthenia gravis', Journal of Neuroimmunology, vol. 199, no. 1-2, pp. 151-154. https://doi.org/10.1016/j.jneuroim.2008.05.010

Serum BAFF expression in patients with myasthenia gravis. / Kim, Jee Young; Yang, Young; Moon, Joon Shik; Lee, Eun Young; So, Sun Hwha; Lee, Hong Soo; Park, Kee Duk; Choi, Youngchul.

In: Journal of Neuroimmunology, Vol. 199, No. 1-2, 13.08.2008, p. 151-154.

Research output: Contribution to journalArticle

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AB - A B-cell activating factor of the tumor necrosis factor (TNF) family (BAFF) is an essential B-cell survival factor. Myasthenia gravis (MG) is one of the most typical antibody-mediated autoimmune disorders. To test whether serum BAFF levels are increased in MG patients, we compared the serum BAFF levels of 40 MG patients with those of 30 healthy controls. Serum BAFF levels of MG group were significantly higher than those of healthy group. These results suggested that the BAFF might play a role in the immunopathogenesis of MG and further study on B-cell and T-cell activation may be needed.

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Kim JY, Yang Y, Moon JS, Lee EY, So SH, Lee HS et al. Serum BAFF expression in patients with myasthenia gravis. Journal of Neuroimmunology. 2008 Aug 13;199(1-2):151-154. https://doi.org/10.1016/j.jneuroim.2008.05.010