Serum C-reactive protein: A predictor of mortality in continuous ambulatory peritoneal dialysis patients

Hyunjin Noh, Seoung Woo Lee, Shin Wook Kang, Sug Kyun Shin, Kyu Hun Choi, Ho Yung Lee, Dae Suk Han

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the predictive value of a single baseline serum C-reactive protein (sCRP) as a marker of mortality in continuous ambulatory peritoneal dialysis (CAPD) patients. Design: A review of prospectively collected data in a 2-year follow-up study. Setting: Tertiary medical center. Patients: The study included 106 patients who were stable and had been on CAPD for a minimum of 3 months. Main Outcome Measures: Patient survival rate was the main outcome measure of this study. Other outcome measures were technique survival rate, peritonitis rate, and hospitalized days. Covariables used in the survival analysis were age, sex, the presence of cardiovascular disease or diabetes mellitus, sCRP, serum albumin, hematocrit, cholesterol, HDL-cholesterol, malnutrition by subjective global assessment (SGA), weekly Kt/V urea, and weekly standardized creatinine clearance (SCCr). Results: The 2-year patient survival rate was significantly lower in the increased sCRP group than in the normal sCRP group (66.7% vs 94.1%, p = 0.001), although there was no significant difference in technique failure, peritonitis rate, and hospitalized days between the two groups. By Cox proportional hazards analysis, independent predictors of mortality were: cardiovascular disease (relative risk, RR = 8.96, p < 0.005); increased sCRP level (RR = 1.19, p < 0.05); and high hematocrit (RR = 1.18, p < 0.05). Conclusion: Serum CRP at enrollment is an independent predictor of 2-year patient survival in CAPD patients.

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalPeritoneal Dialysis International
Volume18
Issue number4
Publication statusPublished - 1998 Jul 1

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Continuous Ambulatory Peritoneal Dialysis
Staphylococcal Protein A
C-Reactive Protein
Blood Proteins
Mortality
Outcome Assessment (Health Care)
Survival Rate
Peritonitis
Hematocrit
Cardiovascular Diseases
Survival Analysis
Serum Albumin
Malnutrition
HDL Cholesterol
Urea
Creatinine
Diabetes Mellitus
Cholesterol
Survival
Serum

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Noh, H., Lee, S. W., Kang, S. W., Shin, S. K., Choi, K. H., Lee, H. Y., & Han, D. S. (1998). Serum C-reactive protein: A predictor of mortality in continuous ambulatory peritoneal dialysis patients. Peritoneal Dialysis International, 18(4), 387-394.
Noh, Hyunjin ; Lee, Seoung Woo ; Kang, Shin Wook ; Shin, Sug Kyun ; Choi, Kyu Hun ; Lee, Ho Yung ; Han, Dae Suk. / Serum C-reactive protein : A predictor of mortality in continuous ambulatory peritoneal dialysis patients. In: Peritoneal Dialysis International. 1998 ; Vol. 18, No. 4. pp. 387-394.
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Serum C-reactive protein : A predictor of mortality in continuous ambulatory peritoneal dialysis patients. / Noh, Hyunjin; Lee, Seoung Woo; Kang, Shin Wook; Shin, Sug Kyun; Choi, Kyu Hun; Lee, Ho Yung; Han, Dae Suk.

In: Peritoneal Dialysis International, Vol. 18, No. 4, 01.07.1998, p. 387-394.

Research output: Contribution to journalArticle

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T2 - A predictor of mortality in continuous ambulatory peritoneal dialysis patients

AU - Noh, Hyunjin

AU - Lee, Seoung Woo

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AU - Lee, Ho Yung

AU - Han, Dae Suk

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N2 - Objective: To evaluate the predictive value of a single baseline serum C-reactive protein (sCRP) as a marker of mortality in continuous ambulatory peritoneal dialysis (CAPD) patients. Design: A review of prospectively collected data in a 2-year follow-up study. Setting: Tertiary medical center. Patients: The study included 106 patients who were stable and had been on CAPD for a minimum of 3 months. Main Outcome Measures: Patient survival rate was the main outcome measure of this study. Other outcome measures were technique survival rate, peritonitis rate, and hospitalized days. Covariables used in the survival analysis were age, sex, the presence of cardiovascular disease or diabetes mellitus, sCRP, serum albumin, hematocrit, cholesterol, HDL-cholesterol, malnutrition by subjective global assessment (SGA), weekly Kt/V urea, and weekly standardized creatinine clearance (SCCr). Results: The 2-year patient survival rate was significantly lower in the increased sCRP group than in the normal sCRP group (66.7% vs 94.1%, p = 0.001), although there was no significant difference in technique failure, peritonitis rate, and hospitalized days between the two groups. By Cox proportional hazards analysis, independent predictors of mortality were: cardiovascular disease (relative risk, RR = 8.96, p < 0.005); increased sCRP level (RR = 1.19, p < 0.05); and high hematocrit (RR = 1.18, p < 0.05). Conclusion: Serum CRP at enrollment is an independent predictor of 2-year patient survival in CAPD patients.

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