Serum Carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers

Jee Yon Lee, Hyang Kyu Lee, Duk Chul Lee, Ji Won Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Carcinoembryonic antigen (CEA) is a tumor marker overexpressed in adenocarcinoma that has proinflammatory properties. Recent studies have reported that CEA is positively associated with carotid atherosclerosis and metabolic syndrome. Because visceral obesity is a known risk factor for cardiometabolic diseases, CEA may also be associated with visceral adiposity. Therefore, we investigated the relationship between serum CEA concentration and visceral obesity in female Korean nonsmokers. Methods: A total of 270 Korean female nonsmokers were enrolled during their routine health check-ups. Biomarkers of metabolic risk factors were assessed along with body composition by computed tomography. Serum CEA levels were measured by using a chemiluminescence immunoassay analyzer. Results: Serum CEA levels correlated with visceral fat area, fasting glucose, and triglyceride levels after adjusting for age and BMI. The mean visceral fat area increased significantly with the increasing CEA tirtiles. In a step-wise multiple regression analysis, age (β = 0.26, p<0.01) and visceral fat area (β = 0.19, p = 0.03) were identified as explanatory variables for serum CEA level. Conclusions: This study suggested that CEA may be a mediator that links metabolic disturbance and tumorigenesis in visceral obesity. Further studies are required to better understand the clinical and pathophysiological significance of our findings.

Original languageEnglish
Article numbere43518
JournalPloS one
Volume7
Issue number8
DOIs
Publication statusPublished - 2012 Aug 27

Fingerprint

visceral fat
Intra-Abdominal Fat
Carcinoembryonic Antigen
Fats
antigens
Serum
Abdominal Obesity
obesity
chemiluminescence immunoassays
risk factors
Carotid Artery Diseases
Chemiluminescence
metabolic syndrome
Adiposity
adiposity
Biomarkers
Tumor Biomarkers
Luminescence
adenocarcinoma
Body Composition

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

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title = "Serum Carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers",
abstract = "Background: Carcinoembryonic antigen (CEA) is a tumor marker overexpressed in adenocarcinoma that has proinflammatory properties. Recent studies have reported that CEA is positively associated with carotid atherosclerosis and metabolic syndrome. Because visceral obesity is a known risk factor for cardiometabolic diseases, CEA may also be associated with visceral adiposity. Therefore, we investigated the relationship between serum CEA concentration and visceral obesity in female Korean nonsmokers. Methods: A total of 270 Korean female nonsmokers were enrolled during their routine health check-ups. Biomarkers of metabolic risk factors were assessed along with body composition by computed tomography. Serum CEA levels were measured by using a chemiluminescence immunoassay analyzer. Results: Serum CEA levels correlated with visceral fat area, fasting glucose, and triglyceride levels after adjusting for age and BMI. The mean visceral fat area increased significantly with the increasing CEA tirtiles. In a step-wise multiple regression analysis, age (β = 0.26, p<0.01) and visceral fat area (β = 0.19, p = 0.03) were identified as explanatory variables for serum CEA level. Conclusions: This study suggested that CEA may be a mediator that links metabolic disturbance and tumorigenesis in visceral obesity. Further studies are required to better understand the clinical and pathophysiological significance of our findings.",
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Serum Carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers. / Lee, Jee Yon; Lee, Hyang Kyu; Lee, Duk Chul; Lee, Ji Won.

In: PloS one, Vol. 7, No. 8, e43518, 27.08.2012.

Research output: Contribution to journalArticle

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AU - Lee, Hyang Kyu

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AU - Lee, Ji Won

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