Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors

A pilot study

Jee Yon Lee, Mi Kyung Lee, Namkyu Kim, Sang Hui Chu, Duk Chul Lee, Hye Sun Lee, Ji Won Lee, Justin Y. Jeon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Colorectal cancer (CRC) survivors are known to experience various symptoms that significantly affect their quality of life (QOL); therefore, it is important to identify clinical markers related with CRC survivor QOL. Here we investigated the relationship between serum chemerin levels, a newly identified proinflammatory adipokine, and QOL in CRC survivors. Methods A data of total of 110 CRC survivors were analysed in the study. Serum chemerin levels were measured with an enzyme immunoassay analyser. Functional Assessment of Cancer Therapy (FACT) scores were used as an indicator of QOL in CRC survivors. Results Weak but not negligible relationships were observed between serum chemerin levels and FACT-General (G) (r =-0.22, p<0.02), FACT-Colorectal cancer (C) (r =-0.23, p<0.02) and FACT-Fatigue (F) scores (r =-0.27, p<0.01) after adjusting for confounding factors. Both stepwise and enter method multiple linear regression analyses confirmed that serum chemerin levels were independently associated with FACT-G (stepwise: β =-0.15, p<0.01; enter: β =-0.12, p = 0.02), FACT-C (stepwise: β =-0.19, p<0.01; enter; β =-0.14, p = 0.02) and FACT-F scores (stepwise: β =-0.23, p<0.01; enter: β =-0.20, p<0.01). Conclusions Our results demonstrate a weak inverse relationship between serum chemerin and CRC survivor QOL. Although it is impossible to determine causality, our findings suggest that serum chemerin levels may have a significant association with CRC survivor QOL. Further prospective studies are required to confirm the clinical significance of our pilot study.

Original languageEnglish
Article numbere0176929
JournalPloS one
Volume12
Issue number5
DOIs
Publication statusPublished - 2017 May 1

Fingerprint

Functional assessment
colorectal neoplasms
quality of life
Survivors
Colorectal Neoplasms
Quality of Life
therapeutics
neoplasms
Serum
Neoplasms
Therapeutics
Adipokines
adipokines
Linear regression
enzyme immunoassays
prospective studies
Immunoenzyme Techniques
Causality
Fatigue
Linear Models

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{47c7ade7856246079e0afb398bb036b0,
title = "Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study",
abstract = "Background Colorectal cancer (CRC) survivors are known to experience various symptoms that significantly affect their quality of life (QOL); therefore, it is important to identify clinical markers related with CRC survivor QOL. Here we investigated the relationship between serum chemerin levels, a newly identified proinflammatory adipokine, and QOL in CRC survivors. Methods A data of total of 110 CRC survivors were analysed in the study. Serum chemerin levels were measured with an enzyme immunoassay analyser. Functional Assessment of Cancer Therapy (FACT) scores were used as an indicator of QOL in CRC survivors. Results Weak but not negligible relationships were observed between serum chemerin levels and FACT-General (G) (r =-0.22, p<0.02), FACT-Colorectal cancer (C) (r =-0.23, p<0.02) and FACT-Fatigue (F) scores (r =-0.27, p<0.01) after adjusting for confounding factors. Both stepwise and enter method multiple linear regression analyses confirmed that serum chemerin levels were independently associated with FACT-G (stepwise: β =-0.15, p<0.01; enter: β =-0.12, p = 0.02), FACT-C (stepwise: β =-0.19, p<0.01; enter; β =-0.14, p = 0.02) and FACT-F scores (stepwise: β =-0.23, p<0.01; enter: β =-0.20, p<0.01). Conclusions Our results demonstrate a weak inverse relationship between serum chemerin and CRC survivor QOL. Although it is impossible to determine causality, our findings suggest that serum chemerin levels may have a significant association with CRC survivor QOL. Further prospective studies are required to confirm the clinical significance of our pilot study.",
author = "Lee, {Jee Yon} and Lee, {Mi Kyung} and Namkyu Kim and Chu, {Sang Hui} and Lee, {Duk Chul} and Lee, {Hye Sun} and Lee, {Ji Won} and Jeon, {Justin Y.}",
year = "2017",
month = "5",
day = "1",
doi = "10.1371/journal.pone.0176929",
language = "English",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors : A pilot study. / Lee, Jee Yon; Lee, Mi Kyung; Kim, Namkyu; Chu, Sang Hui; Lee, Duk Chul; Lee, Hye Sun; Lee, Ji Won; Jeon, Justin Y.

In: PloS one, Vol. 12, No. 5, e0176929, 01.05.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors

T2 - A pilot study

AU - Lee, Jee Yon

AU - Lee, Mi Kyung

AU - Kim, Namkyu

AU - Chu, Sang Hui

AU - Lee, Duk Chul

AU - Lee, Hye Sun

AU - Lee, Ji Won

AU - Jeon, Justin Y.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background Colorectal cancer (CRC) survivors are known to experience various symptoms that significantly affect their quality of life (QOL); therefore, it is important to identify clinical markers related with CRC survivor QOL. Here we investigated the relationship between serum chemerin levels, a newly identified proinflammatory adipokine, and QOL in CRC survivors. Methods A data of total of 110 CRC survivors were analysed in the study. Serum chemerin levels were measured with an enzyme immunoassay analyser. Functional Assessment of Cancer Therapy (FACT) scores were used as an indicator of QOL in CRC survivors. Results Weak but not negligible relationships were observed between serum chemerin levels and FACT-General (G) (r =-0.22, p<0.02), FACT-Colorectal cancer (C) (r =-0.23, p<0.02) and FACT-Fatigue (F) scores (r =-0.27, p<0.01) after adjusting for confounding factors. Both stepwise and enter method multiple linear regression analyses confirmed that serum chemerin levels were independently associated with FACT-G (stepwise: β =-0.15, p<0.01; enter: β =-0.12, p = 0.02), FACT-C (stepwise: β =-0.19, p<0.01; enter; β =-0.14, p = 0.02) and FACT-F scores (stepwise: β =-0.23, p<0.01; enter: β =-0.20, p<0.01). Conclusions Our results demonstrate a weak inverse relationship between serum chemerin and CRC survivor QOL. Although it is impossible to determine causality, our findings suggest that serum chemerin levels may have a significant association with CRC survivor QOL. Further prospective studies are required to confirm the clinical significance of our pilot study.

AB - Background Colorectal cancer (CRC) survivors are known to experience various symptoms that significantly affect their quality of life (QOL); therefore, it is important to identify clinical markers related with CRC survivor QOL. Here we investigated the relationship between serum chemerin levels, a newly identified proinflammatory adipokine, and QOL in CRC survivors. Methods A data of total of 110 CRC survivors were analysed in the study. Serum chemerin levels were measured with an enzyme immunoassay analyser. Functional Assessment of Cancer Therapy (FACT) scores were used as an indicator of QOL in CRC survivors. Results Weak but not negligible relationships were observed between serum chemerin levels and FACT-General (G) (r =-0.22, p<0.02), FACT-Colorectal cancer (C) (r =-0.23, p<0.02) and FACT-Fatigue (F) scores (r =-0.27, p<0.01) after adjusting for confounding factors. Both stepwise and enter method multiple linear regression analyses confirmed that serum chemerin levels were independently associated with FACT-G (stepwise: β =-0.15, p<0.01; enter: β =-0.12, p = 0.02), FACT-C (stepwise: β =-0.19, p<0.01; enter; β =-0.14, p = 0.02) and FACT-F scores (stepwise: β =-0.23, p<0.01; enter: β =-0.20, p<0.01). Conclusions Our results demonstrate a weak inverse relationship between serum chemerin and CRC survivor QOL. Although it is impossible to determine causality, our findings suggest that serum chemerin levels may have a significant association with CRC survivor QOL. Further prospective studies are required to confirm the clinical significance of our pilot study.

UR - http://www.scopus.com/inward/record.url?scp=85019025115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019025115&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0176929

DO - 10.1371/journal.pone.0176929

M3 - Article

VL - 12

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e0176929

ER -