Serum cystatin C level

An excellent predictor of mortality in patients with cirrhotic ascites

Yeon Seok Seo, Soo Young Park, Moonyoung Kim, Sang Gyune Kim, Junyong Park, Hyung Joon Yim, Byoung Kuk Jang, Seung Ha Park, Ji Hoon Kim, Ki Tae Suk, Jin Dong Kim, Tae Yeob Kim, Eun Young Cho, Jun Sung Lee, Soung Won Jung, Jae Young Jang, Hyonggin An, Won Young Tak, Soonkoo Baik, Jae Seok Hwang & 3 others Young Seok Kim, Joo Hyun Sohn, Soon Ho Um

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Aim: Although serum cystatin C level is considered a more accurate marker of renal function in patients with liver cirrhosis, its prognostic efficacy remains uncertain. This study aimed to evaluate the prognostic efficacy of serum cystatin C level in patients with cirrhotic ascites. Methods: Patients with cirrhotic ascites from 15 hospitals were prospectively enrolled between September 2009 and March 2013. Cox regression analyses were performed to identify independent predictive factors of mortality and development of type 1 hepatorenal syndrome (HRS-1). Results: In total, 350 patients were enrolled in this study. The mean age was 55.4 ± 10.8 years, and 267 patients (76.3%) were men. The leading cause of liver cirrhosis was alcoholic liver disease (64.3%), followed by chronic viral hepatitis (29.7%). Serum creatinine and cystatin C levels were 0.9 ± 0.4 mg/dL and 1.1 ± 0.5 mg/L, respectively. Multivariate analyses revealed that international normalized ratio and serum bilirubin, sodium, and cystatin C levels were independent predictors of mortality and international normalized ratio and serum sodium and cystatin C levels were independent predictors of the development of HRS-1. Serum creatinine level was not significantly associated with mortality and development of HRS-1 on multivariate analysis. Conclusion: Serum cystatin C level was an independent predictor of mortality and development of HRS-1 in patients with cirrhotic ascites, while serum creatinine level was not. Predictive models based on serum cystatin C level instead of serum creatinine level would be more helpful in the assessment of the condition and prognosis of patients with cirrhotic ascites.

Original languageEnglish
Pages (from-to)910-917
Number of pages8
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume33
Issue number4
DOIs
Publication statusPublished - 2018 Apr 1

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Cystatin C
Ascites
Mortality
Serum
Creatinine
International Normalized Ratio
Liver Cirrhosis
Multivariate Analysis
Sodium
Hepatorenal Syndrome
Alcoholic Liver Diseases
Chronic Hepatitis
Bilirubin
Regression Analysis
Kidney

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Seo, Yeon Seok ; Park, Soo Young ; Kim, Moonyoung ; Kim, Sang Gyune ; Park, Junyong ; Yim, Hyung Joon ; Jang, Byoung Kuk ; Park, Seung Ha ; Kim, Ji Hoon ; Suk, Ki Tae ; Kim, Jin Dong ; Kim, Tae Yeob ; Cho, Eun Young ; Lee, Jun Sung ; Jung, Soung Won ; Jang, Jae Young ; An, Hyonggin ; Tak, Won Young ; Baik, Soonkoo ; Hwang, Jae Seok ; Kim, Young Seok ; Sohn, Joo Hyun ; Um, Soon Ho. / Serum cystatin C level : An excellent predictor of mortality in patients with cirrhotic ascites. In: Journal of Gastroenterology and Hepatology (Australia). 2018 ; Vol. 33, No. 4. pp. 910-917.
@article{68e88c75cead4957aec93811164b1544,
title = "Serum cystatin C level: An excellent predictor of mortality in patients with cirrhotic ascites",
abstract = "Background and Aim: Although serum cystatin C level is considered a more accurate marker of renal function in patients with liver cirrhosis, its prognostic efficacy remains uncertain. This study aimed to evaluate the prognostic efficacy of serum cystatin C level in patients with cirrhotic ascites. Methods: Patients with cirrhotic ascites from 15 hospitals were prospectively enrolled between September 2009 and March 2013. Cox regression analyses were performed to identify independent predictive factors of mortality and development of type 1 hepatorenal syndrome (HRS-1). Results: In total, 350 patients were enrolled in this study. The mean age was 55.4 ± 10.8 years, and 267 patients (76.3{\%}) were men. The leading cause of liver cirrhosis was alcoholic liver disease (64.3{\%}), followed by chronic viral hepatitis (29.7{\%}). Serum creatinine and cystatin C levels were 0.9 ± 0.4 mg/dL and 1.1 ± 0.5 mg/L, respectively. Multivariate analyses revealed that international normalized ratio and serum bilirubin, sodium, and cystatin C levels were independent predictors of mortality and international normalized ratio and serum sodium and cystatin C levels were independent predictors of the development of HRS-1. Serum creatinine level was not significantly associated with mortality and development of HRS-1 on multivariate analysis. Conclusion: Serum cystatin C level was an independent predictor of mortality and development of HRS-1 in patients with cirrhotic ascites, while serum creatinine level was not. Predictive models based on serum cystatin C level instead of serum creatinine level would be more helpful in the assessment of the condition and prognosis of patients with cirrhotic ascites.",
author = "Seo, {Yeon Seok} and Park, {Soo Young} and Moonyoung Kim and Kim, {Sang Gyune} and Junyong Park and Yim, {Hyung Joon} and Jang, {Byoung Kuk} and Park, {Seung Ha} and Kim, {Ji Hoon} and Suk, {Ki Tae} and Kim, {Jin Dong} and Kim, {Tae Yeob} and Cho, {Eun Young} and Lee, {Jun Sung} and Jung, {Soung Won} and Jang, {Jae Young} and Hyonggin An and Tak, {Won Young} and Soonkoo Baik and Hwang, {Jae Seok} and Kim, {Young Seok} and Sohn, {Joo Hyun} and Um, {Soon Ho}",
year = "2018",
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doi = "10.1111/jgh.13983",
language = "English",
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journal = "Journal of Gastroenterology and Hepatology (Australia)",
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Seo, YS, Park, SY, Kim, M, Kim, SG, Park, J, Yim, HJ, Jang, BK, Park, SH, Kim, JH, Suk, KT, Kim, JD, Kim, TY, Cho, EY, Lee, JS, Jung, SW, Jang, JY, An, H, Tak, WY, Baik, S, Hwang, JS, Kim, YS, Sohn, JH & Um, SH 2018, 'Serum cystatin C level: An excellent predictor of mortality in patients with cirrhotic ascites', Journal of Gastroenterology and Hepatology (Australia), vol. 33, no. 4, pp. 910-917. https://doi.org/10.1111/jgh.13983

Serum cystatin C level : An excellent predictor of mortality in patients with cirrhotic ascites. / Seo, Yeon Seok; Park, Soo Young; Kim, Moonyoung; Kim, Sang Gyune; Park, Junyong; Yim, Hyung Joon; Jang, Byoung Kuk; Park, Seung Ha; Kim, Ji Hoon; Suk, Ki Tae; Kim, Jin Dong; Kim, Tae Yeob; Cho, Eun Young; Lee, Jun Sung; Jung, Soung Won; Jang, Jae Young; An, Hyonggin; Tak, Won Young; Baik, Soonkoo; Hwang, Jae Seok; Kim, Young Seok; Sohn, Joo Hyun; Um, Soon Ho.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 33, No. 4, 01.04.2018, p. 910-917.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum cystatin C level

T2 - An excellent predictor of mortality in patients with cirrhotic ascites

AU - Seo, Yeon Seok

AU - Park, Soo Young

AU - Kim, Moonyoung

AU - Kim, Sang Gyune

AU - Park, Junyong

AU - Yim, Hyung Joon

AU - Jang, Byoung Kuk

AU - Park, Seung Ha

AU - Kim, Ji Hoon

AU - Suk, Ki Tae

AU - Kim, Jin Dong

AU - Kim, Tae Yeob

AU - Cho, Eun Young

AU - Lee, Jun Sung

AU - Jung, Soung Won

AU - Jang, Jae Young

AU - An, Hyonggin

AU - Tak, Won Young

AU - Baik, Soonkoo

AU - Hwang, Jae Seok

AU - Kim, Young Seok

AU - Sohn, Joo Hyun

AU - Um, Soon Ho

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background and Aim: Although serum cystatin C level is considered a more accurate marker of renal function in patients with liver cirrhosis, its prognostic efficacy remains uncertain. This study aimed to evaluate the prognostic efficacy of serum cystatin C level in patients with cirrhotic ascites. Methods: Patients with cirrhotic ascites from 15 hospitals were prospectively enrolled between September 2009 and March 2013. Cox regression analyses were performed to identify independent predictive factors of mortality and development of type 1 hepatorenal syndrome (HRS-1). Results: In total, 350 patients were enrolled in this study. The mean age was 55.4 ± 10.8 years, and 267 patients (76.3%) were men. The leading cause of liver cirrhosis was alcoholic liver disease (64.3%), followed by chronic viral hepatitis (29.7%). Serum creatinine and cystatin C levels were 0.9 ± 0.4 mg/dL and 1.1 ± 0.5 mg/L, respectively. Multivariate analyses revealed that international normalized ratio and serum bilirubin, sodium, and cystatin C levels were independent predictors of mortality and international normalized ratio and serum sodium and cystatin C levels were independent predictors of the development of HRS-1. Serum creatinine level was not significantly associated with mortality and development of HRS-1 on multivariate analysis. Conclusion: Serum cystatin C level was an independent predictor of mortality and development of HRS-1 in patients with cirrhotic ascites, while serum creatinine level was not. Predictive models based on serum cystatin C level instead of serum creatinine level would be more helpful in the assessment of the condition and prognosis of patients with cirrhotic ascites.

AB - Background and Aim: Although serum cystatin C level is considered a more accurate marker of renal function in patients with liver cirrhosis, its prognostic efficacy remains uncertain. This study aimed to evaluate the prognostic efficacy of serum cystatin C level in patients with cirrhotic ascites. Methods: Patients with cirrhotic ascites from 15 hospitals were prospectively enrolled between September 2009 and March 2013. Cox regression analyses were performed to identify independent predictive factors of mortality and development of type 1 hepatorenal syndrome (HRS-1). Results: In total, 350 patients were enrolled in this study. The mean age was 55.4 ± 10.8 years, and 267 patients (76.3%) were men. The leading cause of liver cirrhosis was alcoholic liver disease (64.3%), followed by chronic viral hepatitis (29.7%). Serum creatinine and cystatin C levels were 0.9 ± 0.4 mg/dL and 1.1 ± 0.5 mg/L, respectively. Multivariate analyses revealed that international normalized ratio and serum bilirubin, sodium, and cystatin C levels were independent predictors of mortality and international normalized ratio and serum sodium and cystatin C levels were independent predictors of the development of HRS-1. Serum creatinine level was not significantly associated with mortality and development of HRS-1 on multivariate analysis. Conclusion: Serum cystatin C level was an independent predictor of mortality and development of HRS-1 in patients with cirrhotic ascites, while serum creatinine level was not. Predictive models based on serum cystatin C level instead of serum creatinine level would be more helpful in the assessment of the condition and prognosis of patients with cirrhotic ascites.

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U2 - 10.1111/jgh.13983

DO - 10.1111/jgh.13983

M3 - Article

VL - 33

SP - 910

EP - 917

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 4

ER -