Serum cytokine profiles and their correlations with disease activity in Takayasu's arteritis

M. C. Park, S. W. Lee, YongBeom Park, S. K. Lee

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Objective. To investigate serum profiles of inflammatory cytokines in patients with Takayasu's arteritis (TA) and to determine their correlations with disease activity of TA. Methods. Forty-nine patients with TA and 12 age- and sex-matched controls were studied. Blood samples were obtained and were divided into active and stable disease groups. Paired blood samples were available in 19 patients at the active stage before treatment and at the remitted stage after treatment. Serum tumour necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-6, IL-12 and IL-18 levels were determined by enzyme-linked immunosorbent assay. Results. Serum TNF-α, IL-6 and IL-18 levels of patients with TA were significantly higher than those of controls (P <0.05), but IFN-γ and IL-12 levels were not. Serum IL-6 and IL-18 levels were significantly higher in the active disease group than in the stable disease group (P <0.05), but the levels of TNF-α were not different between the groups. In the 19 patients with paired samples, serum IL-18 levels at the remitted stage after treatment were significantly decreased compared with the active stage before treatment (P <0.001). The changes in IL-18 levels between active and remitted stages correlated well with changes in erythrocyte sedimentation rate (P <0.001). Conclusion. Serum IL-18 and IL-6 levels were elevated in patients with TA, especially in those with active disease. Serum IL-18 levels correlated well with disease activity of TA. These results suggest that IL-6 and IL-18 might contribute to the pathogenesis of TA and that IL-18 could be a useful marker for monitoring disease activity of TA.

Original languageEnglish
Pages (from-to)545-548
Number of pages4
JournalRheumatology
Volume45
Issue number5
DOIs
Publication statusPublished - 2006 May 1

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Takayasu Arteritis
Interleukin-18
Cytokines
Serum
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukin-12
Interferons
Blood Sedimentation
Therapeutics
Enzyme-Linked Immunosorbent Assay

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Pharmacology (medical)

Cite this

Park, M. C. ; Lee, S. W. ; Park, YongBeom ; Lee, S. K. / Serum cytokine profiles and their correlations with disease activity in Takayasu's arteritis. In: Rheumatology. 2006 ; Vol. 45, No. 5. pp. 545-548.
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abstract = "Objective. To investigate serum profiles of inflammatory cytokines in patients with Takayasu's arteritis (TA) and to determine their correlations with disease activity of TA. Methods. Forty-nine patients with TA and 12 age- and sex-matched controls were studied. Blood samples were obtained and were divided into active and stable disease groups. Paired blood samples were available in 19 patients at the active stage before treatment and at the remitted stage after treatment. Serum tumour necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-6, IL-12 and IL-18 levels were determined by enzyme-linked immunosorbent assay. Results. Serum TNF-α, IL-6 and IL-18 levels of patients with TA were significantly higher than those of controls (P <0.05), but IFN-γ and IL-12 levels were not. Serum IL-6 and IL-18 levels were significantly higher in the active disease group than in the stable disease group (P <0.05), but the levels of TNF-α were not different between the groups. In the 19 patients with paired samples, serum IL-18 levels at the remitted stage after treatment were significantly decreased compared with the active stage before treatment (P <0.001). The changes in IL-18 levels between active and remitted stages correlated well with changes in erythrocyte sedimentation rate (P <0.001). Conclusion. Serum IL-18 and IL-6 levels were elevated in patients with TA, especially in those with active disease. Serum IL-18 levels correlated well with disease activity of TA. These results suggest that IL-6 and IL-18 might contribute to the pathogenesis of TA and that IL-18 could be a useful marker for monitoring disease activity of TA.",
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Serum cytokine profiles and their correlations with disease activity in Takayasu's arteritis. / Park, M. C.; Lee, S. W.; Park, YongBeom; Lee, S. K.

In: Rheumatology, Vol. 45, No. 5, 01.05.2006, p. 545-548.

Research output: Contribution to journalArticle

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AU - Park, M. C.

AU - Lee, S. W.

AU - Park, YongBeom

AU - Lee, S. K.

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N2 - Objective. To investigate serum profiles of inflammatory cytokines in patients with Takayasu's arteritis (TA) and to determine their correlations with disease activity of TA. Methods. Forty-nine patients with TA and 12 age- and sex-matched controls were studied. Blood samples were obtained and were divided into active and stable disease groups. Paired blood samples were available in 19 patients at the active stage before treatment and at the remitted stage after treatment. Serum tumour necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-6, IL-12 and IL-18 levels were determined by enzyme-linked immunosorbent assay. Results. Serum TNF-α, IL-6 and IL-18 levels of patients with TA were significantly higher than those of controls (P <0.05), but IFN-γ and IL-12 levels were not. Serum IL-6 and IL-18 levels were significantly higher in the active disease group than in the stable disease group (P <0.05), but the levels of TNF-α were not different between the groups. In the 19 patients with paired samples, serum IL-18 levels at the remitted stage after treatment were significantly decreased compared with the active stage before treatment (P <0.001). The changes in IL-18 levels between active and remitted stages correlated well with changes in erythrocyte sedimentation rate (P <0.001). Conclusion. Serum IL-18 and IL-6 levels were elevated in patients with TA, especially in those with active disease. Serum IL-18 levels correlated well with disease activity of TA. These results suggest that IL-6 and IL-18 might contribute to the pathogenesis of TA and that IL-18 could be a useful marker for monitoring disease activity of TA.

AB - Objective. To investigate serum profiles of inflammatory cytokines in patients with Takayasu's arteritis (TA) and to determine their correlations with disease activity of TA. Methods. Forty-nine patients with TA and 12 age- and sex-matched controls were studied. Blood samples were obtained and were divided into active and stable disease groups. Paired blood samples were available in 19 patients at the active stage before treatment and at the remitted stage after treatment. Serum tumour necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-6, IL-12 and IL-18 levels were determined by enzyme-linked immunosorbent assay. Results. Serum TNF-α, IL-6 and IL-18 levels of patients with TA were significantly higher than those of controls (P <0.05), but IFN-γ and IL-12 levels were not. Serum IL-6 and IL-18 levels were significantly higher in the active disease group than in the stable disease group (P <0.05), but the levels of TNF-α were not different between the groups. In the 19 patients with paired samples, serum IL-18 levels at the remitted stage after treatment were significantly decreased compared with the active stage before treatment (P <0.001). The changes in IL-18 levels between active and remitted stages correlated well with changes in erythrocyte sedimentation rate (P <0.001). Conclusion. Serum IL-18 and IL-6 levels were elevated in patients with TA, especially in those with active disease. Serum IL-18 levels correlated well with disease activity of TA. These results suggest that IL-6 and IL-18 might contribute to the pathogenesis of TA and that IL-18 could be a useful marker for monitoring disease activity of TA.

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