Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis: A prospective cohort study

Kyoung Sook Park, Geun Woo Ryu, Jong Hyun Jhee, Hyung Woo Kim, Seohyun Park, Sul A. Lee, Young Eun Kwon, Yung Ly Kim, Han Jak Ryu, Mi Jung Lee, Seung Hyeok Han, Tae Hyun Yoo, Yong Lim Kim, Yon Su Kim, Chul Woo Yang, Nam Ho Kim, Shin Wook Kang, Jung Tak Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. Methods: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. Results: During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003). Conclusion: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalBlood Purification
Volume40
Issue number3
DOIs
Publication statusPublished - 2015 Oct 1

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Ferritins
Nutritional Status
Dialysis
Cohort Studies
Prospective Studies
Mortality
Renal Dialysis
Serum
Odds Ratio
Korea
Inflammation
Infection

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

Park, Kyoung Sook ; Ryu, Geun Woo ; Jhee, Jong Hyun ; Kim, Hyung Woo ; Park, Seohyun ; Lee, Sul A. ; Kwon, Young Eun ; Kim, Yung Ly ; Ryu, Han Jak ; Lee, Mi Jung ; Han, Seung Hyeok ; Yoo, Tae Hyun ; Kim, Yong Lim ; Kim, Yon Su ; Yang, Chul Woo ; Kim, Nam Ho ; Kang, Shin Wook ; Park, Jung Tak. / Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis : A prospective cohort study. In: Blood Purification. 2015 ; Vol. 40, No. 3. pp. 209-217.
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title = "Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis: A prospective cohort study",
abstract = "Background: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. Methods: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. Results: During a median follow-up of 39 months, 88 (9.3{\%}) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95{\%} CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95{\%} CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95{\%} CI 1.156-2.069, p = 0.003). Conclusion: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.",
author = "Park, {Kyoung Sook} and Ryu, {Geun Woo} and Jhee, {Jong Hyun} and Kim, {Hyung Woo} and Seohyun Park and Lee, {Sul A.} and Kwon, {Young Eun} and Kim, {Yung Ly} and Ryu, {Han Jak} and Lee, {Mi Jung} and Han, {Seung Hyeok} and Yoo, {Tae Hyun} and Kim, {Yong Lim} and Kim, {Yon Su} and Yang, {Chul Woo} and Kim, {Nam Ho} and Kang, {Shin Wook} and Park, {Jung Tak}",
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Park, KS, Ryu, GW, Jhee, JH, Kim, HW, Park, S, Lee, SA, Kwon, YE, Kim, YL, Ryu, HJ, Lee, MJ, Han, SH, Yoo, TH, Kim, YL, Kim, YS, Yang, CW, Kim, NH, Kang, SW & Park, JT 2015, 'Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis: A prospective cohort study', Blood Purification, vol. 40, no. 3, pp. 209-217. https://doi.org/10.1159/000438819

Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis : A prospective cohort study. / Park, Kyoung Sook; Ryu, Geun Woo; Jhee, Jong Hyun; Kim, Hyung Woo; Park, Seohyun; Lee, Sul A.; Kwon, Young Eun; Kim, Yung Ly; Ryu, Han Jak; Lee, Mi Jung; Han, Seung Hyeok; Yoo, Tae Hyun; Kim, Yong Lim; Kim, Yon Su; Yang, Chul Woo; Kim, Nam Ho; Kang, Shin Wook; Park, Jung Tak.

In: Blood Purification, Vol. 40, No. 3, 01.10.2015, p. 209-217.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum ferritin predicts mortality regardless of inflammatory and nutritional status in patients starting dialysis

T2 - A prospective cohort study

AU - Park, Kyoung Sook

AU - Ryu, Geun Woo

AU - Jhee, Jong Hyun

AU - Kim, Hyung Woo

AU - Park, Seohyun

AU - Lee, Sul A.

AU - Kwon, Young Eun

AU - Kim, Yung Ly

AU - Ryu, Han Jak

AU - Lee, Mi Jung

AU - Han, Seung Hyeok

AU - Yoo, Tae Hyun

AU - Kim, Yong Lim

AU - Kim, Yon Su

AU - Yang, Chul Woo

AU - Kim, Nam Ho

AU - Kang, Shin Wook

AU - Park, Jung Tak

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. Methods: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. Results: During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003). Conclusion: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.

AB - Background: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. Methods: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. Results: During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003). Conclusion: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.

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