Serum high-density lipoprotein cholesterol concentration and functional state: The Korean Urban Rural Elderly (KURE) Study

Hansol Choi, Hyeon Chang Kim, Katherine M. Stefani, Ju Mi Lee, Young Mi Yoon, Eun Young Lee, Kyoung Min Kim, Yumie Rhee, Yoosik Youm, Chang Oh Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Functional state and cholesterol metabolism are important for older adults; however, this association has not been fully investigated among community-dwelling older adults. Thus, we investigated the association of HDL cholesterol with multiple functional state measures in an elderly Korean population. Methods This cross-sectional analysis included 3514 participants, aged 65 years or older, who participated in baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2015. HDL cholesterol concentration was analyzed using both continuous and categorical variables. Functional state was assessed by the mini-mental state examination (MMSE), activities of daily living (ADL) scale, instrumental activities of daily living (IADL) scale, timed up-and go (TUG) test, and chair-rise test (CRT). Multiple logistic regression models were used to investigate independent association between HDL cholesterol and functional state, after adjusting for sex, age, body mass index, systolic blood pressure, fasting glucose, lipid-lowering drug, history of cancer and cardiovascular disease, and health behaviors. Results HDL cholesterol concentration was significantly associated with MMSE, ADL, IADL, TUG, and CRT in the unadjusted model. After adjustment for covariates, the association remained significant for MMSE (standardized β = 0.059, p = 0.001), ADL (standardized β = −0.053, p = 0.004), and CRT (standardized β = −0.037, p = 0.037). In fully-adjusted model, Participants who had a lower HDL concentration (<40 mg/dL) showed significantly increased odds for having MMSE decline (OR 1.451, 95% CI 1.119–1.883) and ADL dependency (OR 2.251, 95% CI 1.119–4.526), compared reference group (≥60 mg/dL). Conclusions Higher HDL cholesterol concentration was associated with better functional state among Korean older adults.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalArchives of Gerontology and Geriatrics
Volume71
DOIs
Publication statusPublished - 2017 Jul 1

Fingerprint

Activities of Daily Living
HDL Cholesterol
Serum
examination
Logistic Models
reference group
Blood Pressure
Independent Living
health behavior
Health Behavior
cancer
logistics
Fasting
Body Mass Index
Cohort Studies
Cardiovascular Diseases
drug
Disease
Cross-Sectional Studies
Cholesterol

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Choi, Hansol ; Kim, Hyeon Chang ; Stefani, Katherine M. ; Lee, Ju Mi ; Yoon, Young Mi ; Lee, Eun Young ; Kim, Kyoung Min ; Rhee, Yumie ; Youm, Yoosik ; Kim, Chang Oh. / Serum high-density lipoprotein cholesterol concentration and functional state : The Korean Urban Rural Elderly (KURE) Study. In: Archives of Gerontology and Geriatrics. 2017 ; Vol. 71. pp. 115-121.
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title = "Serum high-density lipoprotein cholesterol concentration and functional state: The Korean Urban Rural Elderly (KURE) Study",
abstract = "Background Functional state and cholesterol metabolism are important for older adults; however, this association has not been fully investigated among community-dwelling older adults. Thus, we investigated the association of HDL cholesterol with multiple functional state measures in an elderly Korean population. Methods This cross-sectional analysis included 3514 participants, aged 65 years or older, who participated in baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2015. HDL cholesterol concentration was analyzed using both continuous and categorical variables. Functional state was assessed by the mini-mental state examination (MMSE), activities of daily living (ADL) scale, instrumental activities of daily living (IADL) scale, timed up-and go (TUG) test, and chair-rise test (CRT). Multiple logistic regression models were used to investigate independent association between HDL cholesterol and functional state, after adjusting for sex, age, body mass index, systolic blood pressure, fasting glucose, lipid-lowering drug, history of cancer and cardiovascular disease, and health behaviors. Results HDL cholesterol concentration was significantly associated with MMSE, ADL, IADL, TUG, and CRT in the unadjusted model. After adjustment for covariates, the association remained significant for MMSE (standardized β = 0.059, p = 0.001), ADL (standardized β = −0.053, p = 0.004), and CRT (standardized β = −0.037, p = 0.037). In fully-adjusted model, Participants who had a lower HDL concentration (<40 mg/dL) showed significantly increased odds for having MMSE decline (OR 1.451, 95{\%} CI 1.119–1.883) and ADL dependency (OR 2.251, 95{\%} CI 1.119–4.526), compared reference group (≥60 mg/dL). Conclusions Higher HDL cholesterol concentration was associated with better functional state among Korean older adults.",
author = "Hansol Choi and Kim, {Hyeon Chang} and Stefani, {Katherine M.} and Lee, {Ju Mi} and Yoon, {Young Mi} and Lee, {Eun Young} and Kim, {Kyoung Min} and Yumie Rhee and Yoosik Youm and Kim, {Chang Oh}",
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Serum high-density lipoprotein cholesterol concentration and functional state : The Korean Urban Rural Elderly (KURE) Study. / Choi, Hansol; Kim, Hyeon Chang; Stefani, Katherine M.; Lee, Ju Mi; Yoon, Young Mi; Lee, Eun Young; Kim, Kyoung Min; Rhee, Yumie; Youm, Yoosik; Kim, Chang Oh.

In: Archives of Gerontology and Geriatrics, Vol. 71, 01.07.2017, p. 115-121.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum high-density lipoprotein cholesterol concentration and functional state

T2 - The Korean Urban Rural Elderly (KURE) Study

AU - Choi, Hansol

AU - Kim, Hyeon Chang

AU - Stefani, Katherine M.

AU - Lee, Ju Mi

AU - Yoon, Young Mi

AU - Lee, Eun Young

AU - Kim, Kyoung Min

AU - Rhee, Yumie

AU - Youm, Yoosik

AU - Kim, Chang Oh

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background Functional state and cholesterol metabolism are important for older adults; however, this association has not been fully investigated among community-dwelling older adults. Thus, we investigated the association of HDL cholesterol with multiple functional state measures in an elderly Korean population. Methods This cross-sectional analysis included 3514 participants, aged 65 years or older, who participated in baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2015. HDL cholesterol concentration was analyzed using both continuous and categorical variables. Functional state was assessed by the mini-mental state examination (MMSE), activities of daily living (ADL) scale, instrumental activities of daily living (IADL) scale, timed up-and go (TUG) test, and chair-rise test (CRT). Multiple logistic regression models were used to investigate independent association between HDL cholesterol and functional state, after adjusting for sex, age, body mass index, systolic blood pressure, fasting glucose, lipid-lowering drug, history of cancer and cardiovascular disease, and health behaviors. Results HDL cholesterol concentration was significantly associated with MMSE, ADL, IADL, TUG, and CRT in the unadjusted model. After adjustment for covariates, the association remained significant for MMSE (standardized β = 0.059, p = 0.001), ADL (standardized β = −0.053, p = 0.004), and CRT (standardized β = −0.037, p = 0.037). In fully-adjusted model, Participants who had a lower HDL concentration (<40 mg/dL) showed significantly increased odds for having MMSE decline (OR 1.451, 95% CI 1.119–1.883) and ADL dependency (OR 2.251, 95% CI 1.119–4.526), compared reference group (≥60 mg/dL). Conclusions Higher HDL cholesterol concentration was associated with better functional state among Korean older adults.

AB - Background Functional state and cholesterol metabolism are important for older adults; however, this association has not been fully investigated among community-dwelling older adults. Thus, we investigated the association of HDL cholesterol with multiple functional state measures in an elderly Korean population. Methods This cross-sectional analysis included 3514 participants, aged 65 years or older, who participated in baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2015. HDL cholesterol concentration was analyzed using both continuous and categorical variables. Functional state was assessed by the mini-mental state examination (MMSE), activities of daily living (ADL) scale, instrumental activities of daily living (IADL) scale, timed up-and go (TUG) test, and chair-rise test (CRT). Multiple logistic regression models were used to investigate independent association between HDL cholesterol and functional state, after adjusting for sex, age, body mass index, systolic blood pressure, fasting glucose, lipid-lowering drug, history of cancer and cardiovascular disease, and health behaviors. Results HDL cholesterol concentration was significantly associated with MMSE, ADL, IADL, TUG, and CRT in the unadjusted model. After adjustment for covariates, the association remained significant for MMSE (standardized β = 0.059, p = 0.001), ADL (standardized β = −0.053, p = 0.004), and CRT (standardized β = −0.037, p = 0.037). In fully-adjusted model, Participants who had a lower HDL concentration (<40 mg/dL) showed significantly increased odds for having MMSE decline (OR 1.451, 95% CI 1.119–1.883) and ADL dependency (OR 2.251, 95% CI 1.119–4.526), compared reference group (≥60 mg/dL). Conclusions Higher HDL cholesterol concentration was associated with better functional state among Korean older adults.

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U2 - 10.1016/j.archger.2017.04.002

DO - 10.1016/j.archger.2017.04.002

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