Serum IgA/C3 ratio may be a useful marker of disease activity in severe Henoch-Schönlein nephritis

Jaeil Shin, Min Park Jee, Ho Shin Youn, Seung Lee Jae, Joo Jeong Hyeon, Hyonsuk Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background/Aims: This study was designed to investigate whether the serum IgA/C3 ratio can be a serologic marker of disease activity in children with severe Henoch-Schönlein nephritis (HSN). Methods: Twelve HSN patients who were treated with steroids and cyclosporine were examined. The levels of serum IgA and C3 were measured using an international reference preparation (IFCC/CRM470) and a renal biopsy was performed in all patients before and after therapy. After therapy, patients were divided into 3 groups: complete remission (n = 6, group I), mild urinary abnormalities (n = 3, group II), and active renal disease (n = 3, group III). Results: The serum IgA/C3 ratio decreased significantly in groups I and II after therapy (2.62 ± 0.82 vs. 2.02 ± 0.52, p = 0.02), whereas the ratio in group III increased, although it was not statistically significant (2.13 ± 0.93 vs. 4.67 ± 1.71, p = 0.25). A follow-up renal biopsy revealed that the activity index was reduced in groups I and II (7.0 ± 2.4 vs. 3.6 ± 1.6, p = 0.016), and not changed in group III (7.3 ± 2.1 vs. 9.3 ± 2.5, p = 0.25). The activity index at a follow-up renal biopsy correlated positively with the changes of the serum IgA/C3 ratio: posttherapy activity index = 1.20 x ΔIgA/C3 + 4.78 (r = 0.635, p = 0.027); where ΔIgA/C3 is posttherapy IgA/C3 - pretherapy IgA/C3. Conclusion: These findings suggest that the serum IgA/C3 ratio may be a useful marker to predict disease activity and histologic severity in HSN.

Original languageEnglish
JournalNephron - Clinical Practice
Volume101
Issue number2
DOIs
Publication statusPublished - 2005 Oct 1

Fingerprint

Nephritis
Immunoglobulin A
Serum
Kidney
Biopsy
Cyclosporine
Therapeutics
Steroids

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Shin, Jaeil ; Jee, Min Park ; Youn, Ho Shin ; Jae, Seung Lee ; Hyeon, Joo Jeong ; Kim, Hyonsuk. / Serum IgA/C3 ratio may be a useful marker of disease activity in severe Henoch-Schönlein nephritis. In: Nephron - Clinical Practice. 2005 ; Vol. 101, No. 2.
@article{280214eafc6b4baa8b3a4c1aa0b91cb7,
title = "Serum IgA/C3 ratio may be a useful marker of disease activity in severe Henoch-Sch{\"o}nlein nephritis",
abstract = "Background/Aims: This study was designed to investigate whether the serum IgA/C3 ratio can be a serologic marker of disease activity in children with severe Henoch-Sch{\"o}nlein nephritis (HSN). Methods: Twelve HSN patients who were treated with steroids and cyclosporine were examined. The levels of serum IgA and C3 were measured using an international reference preparation (IFCC/CRM470) and a renal biopsy was performed in all patients before and after therapy. After therapy, patients were divided into 3 groups: complete remission (n = 6, group I), mild urinary abnormalities (n = 3, group II), and active renal disease (n = 3, group III). Results: The serum IgA/C3 ratio decreased significantly in groups I and II after therapy (2.62 ± 0.82 vs. 2.02 ± 0.52, p = 0.02), whereas the ratio in group III increased, although it was not statistically significant (2.13 ± 0.93 vs. 4.67 ± 1.71, p = 0.25). A follow-up renal biopsy revealed that the activity index was reduced in groups I and II (7.0 ± 2.4 vs. 3.6 ± 1.6, p = 0.016), and not changed in group III (7.3 ± 2.1 vs. 9.3 ± 2.5, p = 0.25). The activity index at a follow-up renal biopsy correlated positively with the changes of the serum IgA/C3 ratio: posttherapy activity index = 1.20 x ΔIgA/C3 + 4.78 (r = 0.635, p = 0.027); where ΔIgA/C3 is posttherapy IgA/C3 - pretherapy IgA/C3. Conclusion: These findings suggest that the serum IgA/C3 ratio may be a useful marker to predict disease activity and histologic severity in HSN.",
author = "Jaeil Shin and Jee, {Min Park} and Youn, {Ho Shin} and Jae, {Seung Lee} and Hyeon, {Joo Jeong} and Hyonsuk Kim",
year = "2005",
month = "10",
day = "1",
doi = "10.1159/000086225",
language = "English",
volume = "101",
journal = "Nephron - Experimental Nephrology",
issn = "1660-8151",
publisher = "S. Karger AG",
number = "2",

}

Serum IgA/C3 ratio may be a useful marker of disease activity in severe Henoch-Schönlein nephritis. / Shin, Jaeil; Jee, Min Park; Youn, Ho Shin; Jae, Seung Lee; Hyeon, Joo Jeong; Kim, Hyonsuk.

In: Nephron - Clinical Practice, Vol. 101, No. 2, 01.10.2005.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum IgA/C3 ratio may be a useful marker of disease activity in severe Henoch-Schönlein nephritis

AU - Shin, Jaeil

AU - Jee, Min Park

AU - Youn, Ho Shin

AU - Jae, Seung Lee

AU - Hyeon, Joo Jeong

AU - Kim, Hyonsuk

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Background/Aims: This study was designed to investigate whether the serum IgA/C3 ratio can be a serologic marker of disease activity in children with severe Henoch-Schönlein nephritis (HSN). Methods: Twelve HSN patients who were treated with steroids and cyclosporine were examined. The levels of serum IgA and C3 were measured using an international reference preparation (IFCC/CRM470) and a renal biopsy was performed in all patients before and after therapy. After therapy, patients were divided into 3 groups: complete remission (n = 6, group I), mild urinary abnormalities (n = 3, group II), and active renal disease (n = 3, group III). Results: The serum IgA/C3 ratio decreased significantly in groups I and II after therapy (2.62 ± 0.82 vs. 2.02 ± 0.52, p = 0.02), whereas the ratio in group III increased, although it was not statistically significant (2.13 ± 0.93 vs. 4.67 ± 1.71, p = 0.25). A follow-up renal biopsy revealed that the activity index was reduced in groups I and II (7.0 ± 2.4 vs. 3.6 ± 1.6, p = 0.016), and not changed in group III (7.3 ± 2.1 vs. 9.3 ± 2.5, p = 0.25). The activity index at a follow-up renal biopsy correlated positively with the changes of the serum IgA/C3 ratio: posttherapy activity index = 1.20 x ΔIgA/C3 + 4.78 (r = 0.635, p = 0.027); where ΔIgA/C3 is posttherapy IgA/C3 - pretherapy IgA/C3. Conclusion: These findings suggest that the serum IgA/C3 ratio may be a useful marker to predict disease activity and histologic severity in HSN.

AB - Background/Aims: This study was designed to investigate whether the serum IgA/C3 ratio can be a serologic marker of disease activity in children with severe Henoch-Schönlein nephritis (HSN). Methods: Twelve HSN patients who were treated with steroids and cyclosporine were examined. The levels of serum IgA and C3 were measured using an international reference preparation (IFCC/CRM470) and a renal biopsy was performed in all patients before and after therapy. After therapy, patients were divided into 3 groups: complete remission (n = 6, group I), mild urinary abnormalities (n = 3, group II), and active renal disease (n = 3, group III). Results: The serum IgA/C3 ratio decreased significantly in groups I and II after therapy (2.62 ± 0.82 vs. 2.02 ± 0.52, p = 0.02), whereas the ratio in group III increased, although it was not statistically significant (2.13 ± 0.93 vs. 4.67 ± 1.71, p = 0.25). A follow-up renal biopsy revealed that the activity index was reduced in groups I and II (7.0 ± 2.4 vs. 3.6 ± 1.6, p = 0.016), and not changed in group III (7.3 ± 2.1 vs. 9.3 ± 2.5, p = 0.25). The activity index at a follow-up renal biopsy correlated positively with the changes of the serum IgA/C3 ratio: posttherapy activity index = 1.20 x ΔIgA/C3 + 4.78 (r = 0.635, p = 0.027); where ΔIgA/C3 is posttherapy IgA/C3 - pretherapy IgA/C3. Conclusion: These findings suggest that the serum IgA/C3 ratio may be a useful marker to predict disease activity and histologic severity in HSN.

UR - http://www.scopus.com/inward/record.url?scp=23944438392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944438392&partnerID=8YFLogxK

U2 - 10.1159/000086225

DO - 10.1159/000086225

M3 - Article

C2 - 15942254

AN - SCOPUS:23944438392

VL - 101

JO - Nephron - Experimental Nephrology

JF - Nephron - Experimental Nephrology

SN - 1660-8151

IS - 2

ER -