Serum interleukin-27 expression in patients with myasthenia gravis

Ha Neul Jeong, Jung Hwan Lee, Bum Chun Suh, Young Chul Choi

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3 Citations (Scopus)

Abstract

Myasthenia gravis (MG)11MG (myasthenia gravis). is an autoimmune disease directed at the neuromuscular junction, and cytokines are thought to contribute to its immunopathogenesis. Interleukin-27 (IL-27)22IL-27 (interleukin-27). plays a complex and pleiotropic role in immune responses associated with T helper cells. To assess the role of IL-27 in MG, we determined serum IL-27 levels in MG patients (n = 32) compared to healthy controls (n = 50). The median serum IL-27 level was significantly higher in MG patients (35.947 pg/mL) than in controls (19.885 pg/mL). Furthermore, serum IL-27 was significantly higher in early onset MG. This study suggests the possibility that IL-27 might contribute to MG pathogenesis or immunoregulation.

Original languageEnglish
Pages (from-to)120-122
Number of pages3
JournalJournal of Neuroimmunology
Volume288
DOIs
Publication statusPublished - 2015 Nov 15

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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