Myasthenia gravis (MG)11MG (myasthenia gravis). is an autoimmune disease directed at the neuromuscular junction, and cytokines are thought to contribute to its immunopathogenesis. Interleukin-27 (IL-27)22IL-27 (interleukin-27). plays a complex and pleiotropic role in immune responses associated with T helper cells. To assess the role of IL-27 in MG, we determined serum IL-27 levels in MG patients (n = 32) compared to healthy controls (n = 50). The median serum IL-27 level was significantly higher in MG patients (35.947 pg/mL) than in controls (19.885 pg/mL). Furthermore, serum IL-27 was significantly higher in early onset MG. This study suggests the possibility that IL-27 might contribute to MG pathogenesis or immunoregulation.
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© 2015 Elsevier B.V..
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Clinical Neurology