Serum levels of advanced glycation end products are associated with in-stent restenosis in diabetic patients

Eui Young Choi, Hyuck Moon Kwon, Chul Woo Ahn, Geun Taek Lee, Boyoung Joung, Bum Kee Hong, Young Won Yoon, Dongsoo Kim, Ki Hyun Byun, Tae Soo Kang, Se Jung Yoon, Sung Woo Kwon, Sung Ju Lee, Jong Kwan Park, Hyun Seung Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The formation of advanced glycation end products (AGEs), in various tissues has been known to enhance immunoinflammatory reactions and local oxidant stresses in long standing diabetes. Recently, AGEs have been reported to play a role in neointimal formation in animal models of arterial injury. We attempted to determine whether the serum levels of AGEs are associated with coronary restenosis in diabetic patients. Blood samples were collected from diabetic patients with coronary artery disease undergoing stent implantation and the serum levels of AGEs were analyzed by the fluorescent intensity method. The development of in-stent restenosis (ISR) was evaluated by a 6-month follow-up coronary angiography. A total of 263 target lesions were evaluated, in 203 patients. The ISR rate in the high-AGE (> 170 U/ml) group (40.1%) was significantly higher than in the low-AGE group (≤ 170 U/ml) (19.6%) (p<0.001). Furthermore, multivariate analysis revealed that a high level of serum AGEs is an independent risk factor for the development of ISR (odds ratio, 2.659; 95% CI, 1.431-4.940; p=0.002). The serum levels of AGEs constitute an excellent predictive factor for ISR, and should be one of the guidelines for medical therapy and interventional strategy to prevent ISR in diabetic patients.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalYonsei medical journal
Volume46
Issue number1
DOIs
Publication statusPublished - 2005 Feb 28

Fingerprint

Advanced Glycosylation End Products
Stents
Serum
Coronary Restenosis
Coronary Angiography
Oxidants
Coronary Artery Disease
Multivariate Analysis
Animal Models
Odds Ratio
Guidelines
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Choi, Eui Young ; Kwon, Hyuck Moon ; Ahn, Chul Woo ; Lee, Geun Taek ; Joung, Boyoung ; Hong, Bum Kee ; Yoon, Young Won ; Kim, Dongsoo ; Byun, Ki Hyun ; Kang, Tae Soo ; Yoon, Se Jung ; Kwon, Sung Woo ; Lee, Sung Ju ; Park, Jong Kwan ; Kim, Hyun Seung. / Serum levels of advanced glycation end products are associated with in-stent restenosis in diabetic patients. In: Yonsei medical journal. 2005 ; Vol. 46, No. 1. pp. 78-85.
@article{321a3f3ee80447c5afa8158db68686c4,
title = "Serum levels of advanced glycation end products are associated with in-stent restenosis in diabetic patients",
abstract = "The formation of advanced glycation end products (AGEs), in various tissues has been known to enhance immunoinflammatory reactions and local oxidant stresses in long standing diabetes. Recently, AGEs have been reported to play a role in neointimal formation in animal models of arterial injury. We attempted to determine whether the serum levels of AGEs are associated with coronary restenosis in diabetic patients. Blood samples were collected from diabetic patients with coronary artery disease undergoing stent implantation and the serum levels of AGEs were analyzed by the fluorescent intensity method. The development of in-stent restenosis (ISR) was evaluated by a 6-month follow-up coronary angiography. A total of 263 target lesions were evaluated, in 203 patients. The ISR rate in the high-AGE (> 170 U/ml) group (40.1{\%}) was significantly higher than in the low-AGE group (≤ 170 U/ml) (19.6{\%}) (p<0.001). Furthermore, multivariate analysis revealed that a high level of serum AGEs is an independent risk factor for the development of ISR (odds ratio, 2.659; 95{\%} CI, 1.431-4.940; p=0.002). The serum levels of AGEs constitute an excellent predictive factor for ISR, and should be one of the guidelines for medical therapy and interventional strategy to prevent ISR in diabetic patients.",
author = "Choi, {Eui Young} and Kwon, {Hyuck Moon} and Ahn, {Chul Woo} and Lee, {Geun Taek} and Boyoung Joung and Hong, {Bum Kee} and Yoon, {Young Won} and Dongsoo Kim and Byun, {Ki Hyun} and Kang, {Tae Soo} and Yoon, {Se Jung} and Kwon, {Sung Woo} and Lee, {Sung Ju} and Park, {Jong Kwan} and Kim, {Hyun Seung}",
year = "2005",
month = "2",
day = "28",
doi = "10.3349/ymj.2005.46.1.78",
language = "English",
volume = "46",
pages = "78--85",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "1",

}

Choi, EY, Kwon, HM, Ahn, CW, Lee, GT, Joung, B, Hong, BK, Yoon, YW, Kim, D, Byun, KH, Kang, TS, Yoon, SJ, Kwon, SW, Lee, SJ, Park, JK & Kim, HS 2005, 'Serum levels of advanced glycation end products are associated with in-stent restenosis in diabetic patients', Yonsei medical journal, vol. 46, no. 1, pp. 78-85. https://doi.org/10.3349/ymj.2005.46.1.78

Serum levels of advanced glycation end products are associated with in-stent restenosis in diabetic patients. / Choi, Eui Young; Kwon, Hyuck Moon; Ahn, Chul Woo; Lee, Geun Taek; Joung, Boyoung; Hong, Bum Kee; Yoon, Young Won; Kim, Dongsoo; Byun, Ki Hyun; Kang, Tae Soo; Yoon, Se Jung; Kwon, Sung Woo; Lee, Sung Ju; Park, Jong Kwan; Kim, Hyun Seung.

In: Yonsei medical journal, Vol. 46, No. 1, 28.02.2005, p. 78-85.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum levels of advanced glycation end products are associated with in-stent restenosis in diabetic patients

AU - Choi, Eui Young

AU - Kwon, Hyuck Moon

AU - Ahn, Chul Woo

AU - Lee, Geun Taek

AU - Joung, Boyoung

AU - Hong, Bum Kee

AU - Yoon, Young Won

AU - Kim, Dongsoo

AU - Byun, Ki Hyun

AU - Kang, Tae Soo

AU - Yoon, Se Jung

AU - Kwon, Sung Woo

AU - Lee, Sung Ju

AU - Park, Jong Kwan

AU - Kim, Hyun Seung

PY - 2005/2/28

Y1 - 2005/2/28

N2 - The formation of advanced glycation end products (AGEs), in various tissues has been known to enhance immunoinflammatory reactions and local oxidant stresses in long standing diabetes. Recently, AGEs have been reported to play a role in neointimal formation in animal models of arterial injury. We attempted to determine whether the serum levels of AGEs are associated with coronary restenosis in diabetic patients. Blood samples were collected from diabetic patients with coronary artery disease undergoing stent implantation and the serum levels of AGEs were analyzed by the fluorescent intensity method. The development of in-stent restenosis (ISR) was evaluated by a 6-month follow-up coronary angiography. A total of 263 target lesions were evaluated, in 203 patients. The ISR rate in the high-AGE (> 170 U/ml) group (40.1%) was significantly higher than in the low-AGE group (≤ 170 U/ml) (19.6%) (p<0.001). Furthermore, multivariate analysis revealed that a high level of serum AGEs is an independent risk factor for the development of ISR (odds ratio, 2.659; 95% CI, 1.431-4.940; p=0.002). The serum levels of AGEs constitute an excellent predictive factor for ISR, and should be one of the guidelines for medical therapy and interventional strategy to prevent ISR in diabetic patients.

AB - The formation of advanced glycation end products (AGEs), in various tissues has been known to enhance immunoinflammatory reactions and local oxidant stresses in long standing diabetes. Recently, AGEs have been reported to play a role in neointimal formation in animal models of arterial injury. We attempted to determine whether the serum levels of AGEs are associated with coronary restenosis in diabetic patients. Blood samples were collected from diabetic patients with coronary artery disease undergoing stent implantation and the serum levels of AGEs were analyzed by the fluorescent intensity method. The development of in-stent restenosis (ISR) was evaluated by a 6-month follow-up coronary angiography. A total of 263 target lesions were evaluated, in 203 patients. The ISR rate in the high-AGE (> 170 U/ml) group (40.1%) was significantly higher than in the low-AGE group (≤ 170 U/ml) (19.6%) (p<0.001). Furthermore, multivariate analysis revealed that a high level of serum AGEs is an independent risk factor for the development of ISR (odds ratio, 2.659; 95% CI, 1.431-4.940; p=0.002). The serum levels of AGEs constitute an excellent predictive factor for ISR, and should be one of the guidelines for medical therapy and interventional strategy to prevent ISR in diabetic patients.

UR - http://www.scopus.com/inward/record.url?scp=20144385742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20144385742&partnerID=8YFLogxK

U2 - 10.3349/ymj.2005.46.1.78

DO - 10.3349/ymj.2005.46.1.78

M3 - Article

C2 - 15744809

AN - SCOPUS:20144385742

VL - 46

SP - 78

EP - 85

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 1

ER -