Serum monokine induced by gamma interferon as a novel biomarker for coronary artery calcification in humans

Hee Tae Yu, Jaewon Oh, Hyuk Jae Chang, Sang Hak Lee, Eui Cheol Shin, Sungha Park

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background T-cell-mediated immune responses play important roles in the progression of atherosclerotic disease. Studies have linked various inflammatory biomarkers with the burden of coronary artery calcification, but the significance of T-cell-specific chemokines in coronary artery calcification has not been confirmed. We aimed to examine the association between serum levels of the monokine induced by gamma interferon (MIG) and the coronary artery calcium score (CACS). Methods We enrolled 456 individuals (285 men, 66.5±5.8 years) who were registered in the Mapo-gu public health center cohort. We selected 228 individuals with a CACS of more than 100 and 228 age-matched and sex-matched individuals with a CACS of less than 100. All participants underwent coronary computed tomography for CACS measuring. Clinical and laboratory variables including serum MIG levels were analyzed at the time of enrollment. Results The serum level of MIG was significantly higher in participants with a CACS of more than 100 (152.1±119.1 vs. 130.3±112.9, P=0.046). Serum MIG levels correlated significantly with CACS (r=0.113, P=0.016), and higher levels of MIG were associated with severe plaque burden (CACS>400, P=0.025). Multiple linear regression analysis showed that serum MIG levels were associated independently with CACS after controlling for confounding factors and medications (β=0.114, P=0.026). Conclusion Serum MIG levels were associated independently with CACS after adjusting for traditional cardiovascular risk factors. These findings suggest that MIG may be used as a novel biomarker for T-cell inflammation and atherosclerotic plaque burden in humans.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalCoronary artery disease
Volume26
Issue number4
DOIs
Publication statusPublished - 2015 Dec 1

Fingerprint

Monokines
Interferon-gamma
Coronary Vessels
Biomarkers
Calcium
Serum
T-Lymphocytes
Atherosclerotic Plaques
Chemokines
Disease Progression
Linear Models
Public Health

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{0f4ac2ed55a94283b678dc56c1bceb54,
title = "Serum monokine induced by gamma interferon as a novel biomarker for coronary artery calcification in humans",
abstract = "Background T-cell-mediated immune responses play important roles in the progression of atherosclerotic disease. Studies have linked various inflammatory biomarkers with the burden of coronary artery calcification, but the significance of T-cell-specific chemokines in coronary artery calcification has not been confirmed. We aimed to examine the association between serum levels of the monokine induced by gamma interferon (MIG) and the coronary artery calcium score (CACS). Methods We enrolled 456 individuals (285 men, 66.5±5.8 years) who were registered in the Mapo-gu public health center cohort. We selected 228 individuals with a CACS of more than 100 and 228 age-matched and sex-matched individuals with a CACS of less than 100. All participants underwent coronary computed tomography for CACS measuring. Clinical and laboratory variables including serum MIG levels were analyzed at the time of enrollment. Results The serum level of MIG was significantly higher in participants with a CACS of more than 100 (152.1±119.1 vs. 130.3±112.9, P=0.046). Serum MIG levels correlated significantly with CACS (r=0.113, P=0.016), and higher levels of MIG were associated with severe plaque burden (CACS>400, P=0.025). Multiple linear regression analysis showed that serum MIG levels were associated independently with CACS after controlling for confounding factors and medications (β=0.114, P=0.026). Conclusion Serum MIG levels were associated independently with CACS after adjusting for traditional cardiovascular risk factors. These findings suggest that MIG may be used as a novel biomarker for T-cell inflammation and atherosclerotic plaque burden in humans.",
author = "Yu, {Hee Tae} and Jaewon Oh and Chang, {Hyuk Jae} and Lee, {Sang Hak} and Shin, {Eui Cheol} and Sungha Park",
year = "2015",
month = "12",
day = "1",
doi = "10.1097/MCA.0000000000000236",
language = "English",
volume = "26",
pages = "317--321",
journal = "Coronary Artery Disease",
issn = "0954-6928",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

Serum monokine induced by gamma interferon as a novel biomarker for coronary artery calcification in humans. / Yu, Hee Tae; Oh, Jaewon; Chang, Hyuk Jae; Lee, Sang Hak; Shin, Eui Cheol; Park, Sungha.

In: Coronary artery disease, Vol. 26, No. 4, 01.12.2015, p. 317-321.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum monokine induced by gamma interferon as a novel biomarker for coronary artery calcification in humans

AU - Yu, Hee Tae

AU - Oh, Jaewon

AU - Chang, Hyuk Jae

AU - Lee, Sang Hak

AU - Shin, Eui Cheol

AU - Park, Sungha

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background T-cell-mediated immune responses play important roles in the progression of atherosclerotic disease. Studies have linked various inflammatory biomarkers with the burden of coronary artery calcification, but the significance of T-cell-specific chemokines in coronary artery calcification has not been confirmed. We aimed to examine the association between serum levels of the monokine induced by gamma interferon (MIG) and the coronary artery calcium score (CACS). Methods We enrolled 456 individuals (285 men, 66.5±5.8 years) who were registered in the Mapo-gu public health center cohort. We selected 228 individuals with a CACS of more than 100 and 228 age-matched and sex-matched individuals with a CACS of less than 100. All participants underwent coronary computed tomography for CACS measuring. Clinical and laboratory variables including serum MIG levels were analyzed at the time of enrollment. Results The serum level of MIG was significantly higher in participants with a CACS of more than 100 (152.1±119.1 vs. 130.3±112.9, P=0.046). Serum MIG levels correlated significantly with CACS (r=0.113, P=0.016), and higher levels of MIG were associated with severe plaque burden (CACS>400, P=0.025). Multiple linear regression analysis showed that serum MIG levels were associated independently with CACS after controlling for confounding factors and medications (β=0.114, P=0.026). Conclusion Serum MIG levels were associated independently with CACS after adjusting for traditional cardiovascular risk factors. These findings suggest that MIG may be used as a novel biomarker for T-cell inflammation and atherosclerotic plaque burden in humans.

AB - Background T-cell-mediated immune responses play important roles in the progression of atherosclerotic disease. Studies have linked various inflammatory biomarkers with the burden of coronary artery calcification, but the significance of T-cell-specific chemokines in coronary artery calcification has not been confirmed. We aimed to examine the association between serum levels of the monokine induced by gamma interferon (MIG) and the coronary artery calcium score (CACS). Methods We enrolled 456 individuals (285 men, 66.5±5.8 years) who were registered in the Mapo-gu public health center cohort. We selected 228 individuals with a CACS of more than 100 and 228 age-matched and sex-matched individuals with a CACS of less than 100. All participants underwent coronary computed tomography for CACS measuring. Clinical and laboratory variables including serum MIG levels were analyzed at the time of enrollment. Results The serum level of MIG was significantly higher in participants with a CACS of more than 100 (152.1±119.1 vs. 130.3±112.9, P=0.046). Serum MIG levels correlated significantly with CACS (r=0.113, P=0.016), and higher levels of MIG were associated with severe plaque burden (CACS>400, P=0.025). Multiple linear regression analysis showed that serum MIG levels were associated independently with CACS after controlling for confounding factors and medications (β=0.114, P=0.026). Conclusion Serum MIG levels were associated independently with CACS after adjusting for traditional cardiovascular risk factors. These findings suggest that MIG may be used as a novel biomarker for T-cell inflammation and atherosclerotic plaque burden in humans.

UR - http://www.scopus.com/inward/record.url?scp=84946903033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946903033&partnerID=8YFLogxK

U2 - 10.1097/MCA.0000000000000236

DO - 10.1097/MCA.0000000000000236

M3 - Article

C2 - 25756330

AN - SCOPUS:84946903033

VL - 26

SP - 317

EP - 321

JO - Coronary Artery Disease

JF - Coronary Artery Disease

SN - 0954-6928

IS - 4

ER -