Serum Neutrophil Gelatinase-Associated Lipocalin and Interleukin-18 as Predictive Biomarkers for Delayed Graft Function After Kidney Transplantation

Eun Young Lee, Myoung Soo Kim, Yongjung Park, Hyon Suk Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Early biomarkers for acute kidney injury after kidney transplantation have been studied because delayed graft function (DGF) is associated with increased risk of acute rejection and graft loss. We investigated the usefulness of serum neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) for the prediction of DGF after kidney transplantation. Materials and Methods: Fifty-nine kidney transplant recipients were included and they were separated into DGF and immediate graft function (IGF) groups. Serum samples were collected on the preoperative day as well as days 1, 5, and 14 after the transplantation, and assayed for NGAL and IL-18. Results: After transplantation, serum levels of NGAL were significantly higher at any time in patients with DGF compared to those with IGF. Serum concentrations of IL-18 were not different between both groups. The receiver operating characteristics(ROC)-area under the curve (AUC) values of NGAL, IL-18, and creatinine on day 1 for the discrimination of DGF from IGF were 0.86, 0.63, and 0.65. On POD1, the sensitivities of NGAL and creatinine were respectively 78.6%, and 50.0% at 77.8% specificity, and the AUC values for any combinations including NGAL and that for NGAL alone were higher than that of creatinine. Conclusion: Serum NGAL is an early and sensitive marker of graft dysfunction in kidney transplantation, while serum IL-18 showed limited values.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalJournal of Clinical Laboratory Analysis
Volume26
Issue number4
DOIs
Publication statusPublished - 2012 Jul 1

Fingerprint

Transplantation (surgical)
Delayed Graft Function
Lipocalins
Gelatinases
Interleukin-18
Biomarkers
Grafts
Kidney Transplantation
Serum
Transplants
Creatinine
Area Under Curve
Transplantation
Lipocalin-2
Graft Rejection
Acute Kidney Injury
ROC Curve
Kidney

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical
  • Microbiology (medical)

Cite this

@article{c0b1fcf3a88e4005969993aa99499d08,
title = "Serum Neutrophil Gelatinase-Associated Lipocalin and Interleukin-18 as Predictive Biomarkers for Delayed Graft Function After Kidney Transplantation",
abstract = "Background: Early biomarkers for acute kidney injury after kidney transplantation have been studied because delayed graft function (DGF) is associated with increased risk of acute rejection and graft loss. We investigated the usefulness of serum neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) for the prediction of DGF after kidney transplantation. Materials and Methods: Fifty-nine kidney transplant recipients were included and they were separated into DGF and immediate graft function (IGF) groups. Serum samples were collected on the preoperative day as well as days 1, 5, and 14 after the transplantation, and assayed for NGAL and IL-18. Results: After transplantation, serum levels of NGAL were significantly higher at any time in patients with DGF compared to those with IGF. Serum concentrations of IL-18 were not different between both groups. The receiver operating characteristics(ROC)-area under the curve (AUC) values of NGAL, IL-18, and creatinine on day 1 for the discrimination of DGF from IGF were 0.86, 0.63, and 0.65. On POD1, the sensitivities of NGAL and creatinine were respectively 78.6{\%}, and 50.0{\%} at 77.8{\%} specificity, and the AUC values for any combinations including NGAL and that for NGAL alone were higher than that of creatinine. Conclusion: Serum NGAL is an early and sensitive marker of graft dysfunction in kidney transplantation, while serum IL-18 showed limited values.",
author = "Lee, {Eun Young} and Kim, {Myoung Soo} and Yongjung Park and Kim, {Hyon Suk}",
year = "2012",
month = "7",
day = "1",
doi = "10.1002/jcla.21520",
language = "English",
volume = "26",
pages = "295--301",
journal = "Journal of Clinical Laboratory Analysis",
issn = "0887-8013",
publisher = "Wiley-Liss Inc.",
number = "4",

}

Serum Neutrophil Gelatinase-Associated Lipocalin and Interleukin-18 as Predictive Biomarkers for Delayed Graft Function After Kidney Transplantation. / Lee, Eun Young; Kim, Myoung Soo; Park, Yongjung; Kim, Hyon Suk.

In: Journal of Clinical Laboratory Analysis, Vol. 26, No. 4, 01.07.2012, p. 295-301.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum Neutrophil Gelatinase-Associated Lipocalin and Interleukin-18 as Predictive Biomarkers for Delayed Graft Function After Kidney Transplantation

AU - Lee, Eun Young

AU - Kim, Myoung Soo

AU - Park, Yongjung

AU - Kim, Hyon Suk

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Background: Early biomarkers for acute kidney injury after kidney transplantation have been studied because delayed graft function (DGF) is associated with increased risk of acute rejection and graft loss. We investigated the usefulness of serum neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) for the prediction of DGF after kidney transplantation. Materials and Methods: Fifty-nine kidney transplant recipients were included and they were separated into DGF and immediate graft function (IGF) groups. Serum samples were collected on the preoperative day as well as days 1, 5, and 14 after the transplantation, and assayed for NGAL and IL-18. Results: After transplantation, serum levels of NGAL were significantly higher at any time in patients with DGF compared to those with IGF. Serum concentrations of IL-18 were not different between both groups. The receiver operating characteristics(ROC)-area under the curve (AUC) values of NGAL, IL-18, and creatinine on day 1 for the discrimination of DGF from IGF were 0.86, 0.63, and 0.65. On POD1, the sensitivities of NGAL and creatinine were respectively 78.6%, and 50.0% at 77.8% specificity, and the AUC values for any combinations including NGAL and that for NGAL alone were higher than that of creatinine. Conclusion: Serum NGAL is an early and sensitive marker of graft dysfunction in kidney transplantation, while serum IL-18 showed limited values.

AB - Background: Early biomarkers for acute kidney injury after kidney transplantation have been studied because delayed graft function (DGF) is associated with increased risk of acute rejection and graft loss. We investigated the usefulness of serum neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) for the prediction of DGF after kidney transplantation. Materials and Methods: Fifty-nine kidney transplant recipients were included and they were separated into DGF and immediate graft function (IGF) groups. Serum samples were collected on the preoperative day as well as days 1, 5, and 14 after the transplantation, and assayed for NGAL and IL-18. Results: After transplantation, serum levels of NGAL were significantly higher at any time in patients with DGF compared to those with IGF. Serum concentrations of IL-18 were not different between both groups. The receiver operating characteristics(ROC)-area under the curve (AUC) values of NGAL, IL-18, and creatinine on day 1 for the discrimination of DGF from IGF were 0.86, 0.63, and 0.65. On POD1, the sensitivities of NGAL and creatinine were respectively 78.6%, and 50.0% at 77.8% specificity, and the AUC values for any combinations including NGAL and that for NGAL alone were higher than that of creatinine. Conclusion: Serum NGAL is an early and sensitive marker of graft dysfunction in kidney transplantation, while serum IL-18 showed limited values.

UR - http://www.scopus.com/inward/record.url?scp=84863995799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863995799&partnerID=8YFLogxK

U2 - 10.1002/jcla.21520

DO - 10.1002/jcla.21520

M3 - Article

C2 - 22811364

AN - SCOPUS:84863995799

VL - 26

SP - 295

EP - 301

JO - Journal of Clinical Laboratory Analysis

JF - Journal of Clinical Laboratory Analysis

SN - 0887-8013

IS - 4

ER -