Serum oxygen radical activity and total antioxidation capacity are related with severities of surgical patient with sepsis

Prospective pilot study

Ji Young Jang, Seung Hwan Lee, Hongjin Shim, JaeGil Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose The purpose of this pilot study was to evaluate the correlation between clinical severity and serum oxygen radical activity (ORA) and total antioxidation capacity (TAC) in critically ill surgical patients with sepsis. Materials and methods The prospective observational study was performed in surgical intensive care unit (SICU) patients with intra-abdominal sepsis. Serum ORA and TAC levels were measured using a spectrophotometry-based antioxidant assay machine. Serum selenium and zinc levels and plasma glutamine concentrations were also determined. Sequential organ failure assessment (SOFA) and multiple organ dysfunction (MOD) scores were calculated to evaluate the severity. Blood tests and severity scores were assessed on days 1, 3, and 7 in the SICU. Results Twenty-seven patients were included. The mean APACHE II score was 22.4. The in-hospital mortality rate was 14.8%. Serum TAC levels correlated positively with SOFA and MOD scores on SICU days 1, 3 and 7, and serum ORA correlated negatively with SOFA and MOD scores on day 3. Serum zinc and selenium levels were lower than normal throughout the observation period. However, there was no significant relationship in clinical severity. Conclusions Serum TAC level may be a useful biomarker to predict severity of critically ill surgical patients with sepsis.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalJournal of Critical Care
Volume39
DOIs
Publication statusPublished - 2017 Jun 1

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Reactive Oxygen Species
Sepsis
Prospective Studies
Organ Dysfunction Scores
Serum
Critical Care
Intensive Care Units
Selenium
Critical Illness
Zinc
APACHE
Spectrophotometry
Hematologic Tests
Hospital Mortality
Glutamine
Observational Studies
Antioxidants
Biomarkers
Observation
Mortality

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

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title = "Serum oxygen radical activity and total antioxidation capacity are related with severities of surgical patient with sepsis: Prospective pilot study",
abstract = "Purpose The purpose of this pilot study was to evaluate the correlation between clinical severity and serum oxygen radical activity (ORA) and total antioxidation capacity (TAC) in critically ill surgical patients with sepsis. Materials and methods The prospective observational study was performed in surgical intensive care unit (SICU) patients with intra-abdominal sepsis. Serum ORA and TAC levels were measured using a spectrophotometry-based antioxidant assay machine. Serum selenium and zinc levels and plasma glutamine concentrations were also determined. Sequential organ failure assessment (SOFA) and multiple organ dysfunction (MOD) scores were calculated to evaluate the severity. Blood tests and severity scores were assessed on days 1, 3, and 7 in the SICU. Results Twenty-seven patients were included. The mean APACHE II score was 22.4. The in-hospital mortality rate was 14.8{\%}. Serum TAC levels correlated positively with SOFA and MOD scores on SICU days 1, 3 and 7, and serum ORA correlated negatively with SOFA and MOD scores on day 3. Serum zinc and selenium levels were lower than normal throughout the observation period. However, there was no significant relationship in clinical severity. Conclusions Serum TAC level may be a useful biomarker to predict severity of critically ill surgical patients with sepsis.",
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Serum oxygen radical activity and total antioxidation capacity are related with severities of surgical patient with sepsis : Prospective pilot study. / Jang, Ji Young; Lee, Seung Hwan; Shim, Hongjin; Lee, JaeGil.

In: Journal of Critical Care, Vol. 39, 01.06.2017, p. 131-136.

Research output: Contribution to journalArticle

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T1 - Serum oxygen radical activity and total antioxidation capacity are related with severities of surgical patient with sepsis

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N2 - Purpose The purpose of this pilot study was to evaluate the correlation between clinical severity and serum oxygen radical activity (ORA) and total antioxidation capacity (TAC) in critically ill surgical patients with sepsis. Materials and methods The prospective observational study was performed in surgical intensive care unit (SICU) patients with intra-abdominal sepsis. Serum ORA and TAC levels were measured using a spectrophotometry-based antioxidant assay machine. Serum selenium and zinc levels and plasma glutamine concentrations were also determined. Sequential organ failure assessment (SOFA) and multiple organ dysfunction (MOD) scores were calculated to evaluate the severity. Blood tests and severity scores were assessed on days 1, 3, and 7 in the SICU. Results Twenty-seven patients were included. The mean APACHE II score was 22.4. The in-hospital mortality rate was 14.8%. Serum TAC levels correlated positively with SOFA and MOD scores on SICU days 1, 3 and 7, and serum ORA correlated negatively with SOFA and MOD scores on day 3. Serum zinc and selenium levels were lower than normal throughout the observation period. However, there was no significant relationship in clinical severity. Conclusions Serum TAC level may be a useful biomarker to predict severity of critically ill surgical patients with sepsis.

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