Serum persistent organic pollutants (POPs) and prostate cancer risk

A case-cohort study

Jung eun Lim, Chungmo Nam, Jiyeon Yang, KoonHo Rha, Kyung Min Lim, Sun Ha Jee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It is still unclear whether persistent organic pollutants (POPs) exposure increases the prostate cancer incidence risk. This prospective cohort study evaluated the associations between serum POPs concentrations and prostate cancer risk. Within a case-cohort study, we identified 110 people diagnosed with prostate cancer and randomly selected 256 sub-cohort participants without prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) congeners and 19 organochlorine pesticides (OCPs) were measured. The hazard ratios (HRs) and 95% confidence interval (95% CI) for determining the associations between POPs and risk of prostate cancer were estimated using the weighted Cox regression model. Compared to the lowest tertile, increased risks of prostate cancer incidence were observed in the upper tertile of following PCBs: the moderately chlorinated (HR: 4.19; 95% CI: 1.30–13.54), the highly chlorinated (HR: 4.14; 95% CI: 1.75–9.79), biologically persistent as CYP1A and CYP2B inducers (HR: 4.44; 95% CI: 1.33–14.83), the sum of non- dioxin-like (HR: 3.47; 95% CI: 1.21–9.98), and ∑PCBs (HR: 4.29; 95% CI: 1.52–12.08). In dose-response curves, ∑PCBs was associated with the increased risk of prostate cancer. Our findings suggested a possible role of POPs in the etiology of prostate cancer.

Original languageEnglish
Pages (from-to)849-856
Number of pages8
JournalInternational Journal of Hygiene and Environmental Health
Volume220
Issue number5
DOIs
Publication statusPublished - 2017 Jul 1

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Prostatic Neoplasms
Cohort Studies
Polychlorinated Biphenyls
Confidence Intervals
Serum
Dioxins
Incidence
Proportional Hazards Models
Pesticides
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Lim, Jung eun ; Nam, Chungmo ; Yang, Jiyeon ; Rha, KoonHo ; Lim, Kyung Min ; Jee, Sun Ha. / Serum persistent organic pollutants (POPs) and prostate cancer risk : A case-cohort study. In: International Journal of Hygiene and Environmental Health. 2017 ; Vol. 220, No. 5. pp. 849-856.
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abstract = "It is still unclear whether persistent organic pollutants (POPs) exposure increases the prostate cancer incidence risk. This prospective cohort study evaluated the associations between serum POPs concentrations and prostate cancer risk. Within a case-cohort study, we identified 110 people diagnosed with prostate cancer and randomly selected 256 sub-cohort participants without prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) congeners and 19 organochlorine pesticides (OCPs) were measured. The hazard ratios (HRs) and 95{\%} confidence interval (95{\%} CI) for determining the associations between POPs and risk of prostate cancer were estimated using the weighted Cox regression model. Compared to the lowest tertile, increased risks of prostate cancer incidence were observed in the upper tertile of following PCBs: the moderately chlorinated (HR: 4.19; 95{\%} CI: 1.30–13.54), the highly chlorinated (HR: 4.14; 95{\%} CI: 1.75–9.79), biologically persistent as CYP1A and CYP2B inducers (HR: 4.44; 95{\%} CI: 1.33–14.83), the sum of non- dioxin-like (HR: 3.47; 95{\%} CI: 1.21–9.98), and ∑PCBs (HR: 4.29; 95{\%} CI: 1.52–12.08). In dose-response curves, ∑PCBs was associated with the increased risk of prostate cancer. Our findings suggested a possible role of POPs in the etiology of prostate cancer.",
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Serum persistent organic pollutants (POPs) and prostate cancer risk : A case-cohort study. / Lim, Jung eun; Nam, Chungmo; Yang, Jiyeon; Rha, KoonHo; Lim, Kyung Min; Jee, Sun Ha.

In: International Journal of Hygiene and Environmental Health, Vol. 220, No. 5, 01.07.2017, p. 849-856.

Research output: Contribution to journalArticle

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