Serum retinol-binding protein-4 levels are increased in HIV-infected subjects with metabolic syndrome receiving highly active antiretroviral therapy

Su Jin Jeong, Bum Sik Chin, Yun Tae Chae, Sung Joon Jin, Nam Su Ku, Ji Hyeon Baek, Sang Hoon Han, Chang Oh Kim, Jun Yong Choi, Young Goo Song, Hyun Chul Lee, June Myung Kim

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Abstract

Metabolic syndrome is an important long term complication in chronic asymptomatic HIV-infected subjects under highly active antiretroviral therapy (HAART), because it can contribute to morbidity and mortality via cardiovascular disease (CVD). Therefore, a predictive marker for early detection of metabolic syndrome may be necessary to prevent CVD in HIV-infected subjects. Retinol-binding protein- 4 (RBP-4) has been shown to be associated with metabolic syndrome in various non-HIV-infected populations. We performed a cross-sectional study to evaluate whether serum RBP-4 levels are correlated with metabolic syndrome in HIV-infected subjects receiving HAART. In total, 98 HIV-infected Koreans who had been receiving HAART for at least 6 months were prospectively enrolled. Metabolic syndrome was diagnosed according to the Adult Treatment Panel III criteria, and serum RBP-4 concentrations were measured using human RBP-4 sandwich enzyme- linked immunosorbent assay. Serum RBP-4 levels were significantly higher in HIV-infected subjects receiving HAART with metabolic syndrome (n=33, 33.9±7.7 μg/mL) than in those without it (n=65, 29.9±7.2 μg/mL) (p=0.012). In multivariate linear regression analysis, the number of components of metabolic syndrome presented and waist circumference were independently, significantly correlated with RBP-4 (p=0.018 and 0.030, respectively). In conclusion, we revealed a strong correlation between RBP-4 and the number of components of metabolic syndrome in HIV-infected subjects receiving HAART.

Original languageEnglish
Pages (from-to)1211-1215
Number of pages5
JournalYonsei medical journal
Volume53
Issue number6
DOIs
Publication statusPublished - 2012 Nov

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Jeong, S. J., Chin, B. S., Chae, Y. T., Jin, S. J., Ku, N. S., Baek, J. H., Han, S. H., Kim, C. O., Choi, J. Y., Song, Y. G., Lee, H. C., & Kim, J. M. (2012). Serum retinol-binding protein-4 levels are increased in HIV-infected subjects with metabolic syndrome receiving highly active antiretroviral therapy. Yonsei medical journal, 53(6), 1211-1215. https://doi.org/10.3349/ymj.2012.53.6.1211