Purpose: The authors designed this study to determine how serum selenium and zinc affect the outcomes of critically ill surgical patients. Methods: The medical records of 162 patients admitted to a surgical intensive care unit (ICU) from October 2010 to July 2012 and managed for more than 3 days were retrospectively investigated. Results: Overall, the mean patient age was 61.2 ± 15.0 years, and the median ICU stay was 5 (3-115) days. The mean Acute Physiologic and Chronic Health Evaluation II score was 18.0 ± 8.0. Eighteen (11.1%) of the study subjects died in ICU. mean selenium levels were 83.5 ± 23.8 ng/dL in the survivor group and 83.3 ± 29.6 ng/dL in the nonsurvivor group, and corresponding mean zinc levels were 46.3 ± 21.7 and 65.6 ± 41.6 μg/dL, respectively. Mean selenium concentrations were significantly different in patients with and without shock (77.9 ± 25.4 and 87.2 ± 23.1 ng/dL, P = .017). Furthermore, mean serum selenium was lower in patients with sepsis than in traumatic or simply postoperative patients (P < .001 and P = .038). Serum Zn was significantly lower in patients with sepsis than in patients with trauma (43.4 ± 25.4 μg/dL vs 54.8 ± 28.1 μg/dL, P = .038). Conclusions: To determine the effects of serum selenium and zinc levels on critically ill surgical patients, a large-scale prospective study is needed.
Bibliographical noteFunding Information:
Financial support: This research was supported by the Basic Science Research Program of the National Research Foundation of Korea funded by the Korea Ministry of Education, Science, and Technology (Grant No. 2012R1A1A2007915 ).
All Science Journal Classification (ASJC) codes
- Critical Care and Intensive Care Medicine