TY - JOUR
T1 - Serum selenium levels in patients with respiratory diseases
T2 - A prospective observational study
AU - Lee, Yo Han
AU - Lee, Seok Jeong
AU - Lee, Myoung Kyu
AU - Lee, Won Yeon
AU - Yong, Suk Joong
AU - Kim, Sang Ha
N1 - Publisher Copyright:
© Journal of Thoracic Disease. All rights reserved.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2016
Y1 - 2016
N2 - Background: Serum selenium levels are lower in critically ill patients as compared with healthy controls. However, there is no data about the difference in serum selenium levels depending on the severity of lung diseases. We aimed to identify the factors associated with low serum selenium levels in critically ill patients with respiratory diseases. Methods: A prospective study was performed in 83 patients with respiratory diseases who had admitted to the intensive care unit (ICU) and general wards. We obtained systemic inflammatory markers, nutritional indicators and prognostic factors as the explanatory variables for the outcome of low serum selenium levels. Results: Serum selenium levels on admission were lower by 28% in the ICU group as compared with the general ward group (70.0±26.4 and 97.9±20.8 ng/mL, respectively, P < 0.001). Low serum selenium levels had a correlation with malnutrition represented by decreases in levels of lymphocyte (R2=0.107, P=0.005) and albumin (R2=0.174, P < 0.001). In addition, low serum selenium levels were associated with an increase in baseline C-reactive protein (CRP) (R2=0.059, P=0.041) and APACHE II scores (R2=0.209, P < 0.001). Lower albumin levels (P=0.032) and higher APACHE II scores (P=0.046) showed a significant correlation with lower serum selenium levels on multivariate analysis. Conclusions: Low serum selenium levels in patients with respiratory diseases have a significant correlation with poor nutritional status and prognosis on admission.
AB - Background: Serum selenium levels are lower in critically ill patients as compared with healthy controls. However, there is no data about the difference in serum selenium levels depending on the severity of lung diseases. We aimed to identify the factors associated with low serum selenium levels in critically ill patients with respiratory diseases. Methods: A prospective study was performed in 83 patients with respiratory diseases who had admitted to the intensive care unit (ICU) and general wards. We obtained systemic inflammatory markers, nutritional indicators and prognostic factors as the explanatory variables for the outcome of low serum selenium levels. Results: Serum selenium levels on admission were lower by 28% in the ICU group as compared with the general ward group (70.0±26.4 and 97.9±20.8 ng/mL, respectively, P < 0.001). Low serum selenium levels had a correlation with malnutrition represented by decreases in levels of lymphocyte (R2=0.107, P=0.005) and albumin (R2=0.174, P < 0.001). In addition, low serum selenium levels were associated with an increase in baseline C-reactive protein (CRP) (R2=0.059, P=0.041) and APACHE II scores (R2=0.209, P < 0.001). Lower albumin levels (P=0.032) and higher APACHE II scores (P=0.046) showed a significant correlation with lower serum selenium levels on multivariate analysis. Conclusions: Low serum selenium levels in patients with respiratory diseases have a significant correlation with poor nutritional status and prognosis on admission.
UR - http://www.scopus.com/inward/record.url?scp=84990879142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84990879142&partnerID=8YFLogxK
U2 - 10.21037/jtd.2016.07.60
DO - 10.21037/jtd.2016.07.60
M3 - Article
AN - SCOPUS:84990879142
VL - 8
SP - 2068
EP - 2078
JO - Journal of Thoracic Disease
JF - Journal of Thoracic Disease
SN - 2072-1439
IS - 8
ER -