To investigate whether high serum triglycerides (TG) level is associated with adverse renal outcomes in patients with non-dialysis chronic kidney disease (CKD), a total of 2,158 subjects from a prospective cohort study (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) were divided into the quartile by serum TG level. The primary outcomes were composite renal events, which is defined as a composite of decline of kidney function (the first occurrence of > 50% decline of estimated glomerular filtration rate or doubling of serum creatinine from the baseline) or onset of end-stage renal disease (initiation of dialysis or kidney transplantation). During the median follow-up of 6.940 years, the cumulative incidence of composite renal event was significantly differed by serum TG level in Kaplan–Meier curve analysis (P < 0.001, by Log-rank test). Cox regression analysis demonstrated that, compared to that of the 1st quartile, the risk of composite renal event was significantly higher in the 4th quartile (adjusted hazard ratio 1.433, 95% confidence interval 1.046 to 1.964). The association between high serum TG level and adverse renal outcome remained consistent in the cause-specific hazard model. Subgroup analyses revealed that the association is modified by age, estimated glomerular filtration rate, and spot urine albumin-to-creatinine ratio. In conclusion, high serum TG level is independently associated with adverse renal outcomes in patients with non-dialysis CKD. Interventional studies are warranted to determine whether lowering serum TG levels may alter the natural course of CKD.
|Journal||Frontiers in Nutrition|
|Publication status||Published - 2022 Nov 24|
Bibliographical noteFunding Information:
This work was supported by the Research Program funded by the Korea Centers for Disease Control and Prevention (2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202, 2019E320100, 2019E320101, 2019E320102, and 2022-11-007), by the National Research Foundation of Korea (NRF) funded by the Korea government (MSIT) (NRF-2020R1F1A1074001 and NRF-2019R1A2C2086276), and a grant (BCRI21042 and BCRI22079) of Chonnam National University Hospital Biomedical Research Institute.
KNOW-CKD: Study Group Clinical Centers. Seoul National University: Curie Ahn, K-HO, Dong Wan Chae, Ho Jun Chin, Hayne Cho Park, Seungmi Lee, Hyun Hwa Jang, and Hyun Jin Cho. Yonsei University, Severance Hospital: Kyu Hun Choi, SH, Tae Hyun Yoo, and Mi Hyun Yu. Kangbuk Samsung Medical Center: Kyubeck Lee and Sooyeon Jin. The Catholic University of Korea, Seoul St. Mary's Hospital: Yong-Soo Kim and Sol Ji Kim. Gachon University, Gil Hospital: Wookyung Chung, Youkyoung Jang, and Ji Hye Park. Eulji University, Eulji General Hospital: Young-Hwan Hwang, Su-Ah Sung, and Jeong Ok So. Chonnam University: SK and Ji Seon Lee. Inje University, Pusan Paik Hospital: Yeong Hoon Kim, Sun Woo Kang, and Yun Jin Kim. Epidemiology and Biostatis-tics, Department of Preventive Medicine, Seoul National University College of Medicine: Byung-Joo Park, Sue Kyung Park, and Juyeon Lee. Coordinating Center. Medical Re-search Collaborating Center, Seoul National University Hospital and Seoul National University College of Medicine: Joongyub Lee, Dayeon Nam, Soohee Kang, and Heejung Ahn. Central Laboratory, Donghee Seo, Lab Genomics, Korea and Dae Yeon Cho, Lab Genomics, Korea. Biobank. Korea Biobank, Korea Centers for Disease Control and Prevention, Osong, Korea. Korea Center for Disease Control and Prevention: Dukhyoung Lee, Hy-ekyung Park (Project Officer), Eunkyeong Jung (Project Officer), Suyeon Jeong, Eunmi Ahn, and Sil-Hea Sung.
Copyright © 2022 Suh, Oh, Choi, Kim, Bae, Oh, Han, Ma and Kim.
All Science Journal Classification (ASJC) codes
- Food Science
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics