Serum uric acid concentration and metabolic syndrome among elderly Koreans: The Korean Urban Rural Elderly (KURE) study

Hansol Choi, HyeonChang Kim, Bo Mi Song, Ji Hye Park, Ju Mi Lee, Da Lim Yoon, Young Mi Yoon, Yumie Rhee, Yoosik Youm, Chang Oh Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Epidemiologic studies have demonstrated that elevated serum uric acid concentration is an independent risk factor for metabolic syndrome. However, few studies have focused on elderly populations. Thus, we investigated the association of serum uric acid concentration with metabolic syndrome in community-dwelling elderly Koreans. Methods: This cross-sectional analysis included 2940 participants (986 men and 1954 women) aged 65 years or older who participated in a baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2014. Serum uric acid concentration was analyzed using both continuous and dichotomous variables. Hyperuricemia was defined as a uric acid concentration ≥7.0 mg/dL in men and ≥6.0 mg/dL in women. Metabolic syndrome was defined according to the 2009 harmonizing definition. Multiple logistic regression models were used to investigate independent association between serum uric acid and metabolic syndrome, after adjusting for age, body mass index, LDL cholesterol, glycated hemoglobin, blood urea nitrogen, estimated glomerular filtration rate health behaviors, and medications. Results: Prevalence of metabolic syndrome and its components increased significantly according to uric acid concentration in both sexes. The adjusted odds ratios for having metabolic syndrome per 1.0 mg/dL higher uric acid concentration were 1.16 (95% CI: 1.03-1.31) in men and 1.27 (95% CI: 1.13-1.42) in women. Hyperuricemia was also associated with metabolic syndrome, with adjusted odds ratios of 1.71 (95% CI: 1.11-2.63) in men and 1.55 (95% CI: 1.05-2.29) in women. Conclusions: Elevated serum uric acid concentration was independently associated with an increased prevalence of metabolic syndrome in community-dwelling elderly Koreans.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalArchives of Gerontology and Geriatrics
Volume64
DOIs
Publication statusPublished - 2016 May 1

Fingerprint

Uric Acid
Serum
Independent Living
Hyperuricemia
health behavior
community
medication
Logistic Models
logistics
Odds Ratio
regression
Blood Urea Nitrogen
Health Behavior
Glycosylated Hemoglobin A
health
Glomerular Filtration Rate
LDL Cholesterol
Epidemiologic Studies
Body Mass Index
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Choi, Hansol ; Kim, HyeonChang ; Song, Bo Mi ; Park, Ji Hye ; Lee, Ju Mi ; Yoon, Da Lim ; Yoon, Young Mi ; Rhee, Yumie ; Youm, Yoosik ; Kim, Chang Oh. / Serum uric acid concentration and metabolic syndrome among elderly Koreans : The Korean Urban Rural Elderly (KURE) study. In: Archives of Gerontology and Geriatrics. 2016 ; Vol. 64. pp. 51-58.
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abstract = "Background: Epidemiologic studies have demonstrated that elevated serum uric acid concentration is an independent risk factor for metabolic syndrome. However, few studies have focused on elderly populations. Thus, we investigated the association of serum uric acid concentration with metabolic syndrome in community-dwelling elderly Koreans. Methods: This cross-sectional analysis included 2940 participants (986 men and 1954 women) aged 65 years or older who participated in a baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2014. Serum uric acid concentration was analyzed using both continuous and dichotomous variables. Hyperuricemia was defined as a uric acid concentration ≥7.0 mg/dL in men and ≥6.0 mg/dL in women. Metabolic syndrome was defined according to the 2009 harmonizing definition. Multiple logistic regression models were used to investigate independent association between serum uric acid and metabolic syndrome, after adjusting for age, body mass index, LDL cholesterol, glycated hemoglobin, blood urea nitrogen, estimated glomerular filtration rate health behaviors, and medications. Results: Prevalence of metabolic syndrome and its components increased significantly according to uric acid concentration in both sexes. The adjusted odds ratios for having metabolic syndrome per 1.0 mg/dL higher uric acid concentration were 1.16 (95{\%} CI: 1.03-1.31) in men and 1.27 (95{\%} CI: 1.13-1.42) in women. Hyperuricemia was also associated with metabolic syndrome, with adjusted odds ratios of 1.71 (95{\%} CI: 1.11-2.63) in men and 1.55 (95{\%} CI: 1.05-2.29) in women. Conclusions: Elevated serum uric acid concentration was independently associated with an increased prevalence of metabolic syndrome in community-dwelling elderly Koreans.",
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Serum uric acid concentration and metabolic syndrome among elderly Koreans : The Korean Urban Rural Elderly (KURE) study. / Choi, Hansol; Kim, HyeonChang; Song, Bo Mi; Park, Ji Hye; Lee, Ju Mi; Yoon, Da Lim; Yoon, Young Mi; Rhee, Yumie; Youm, Yoosik; Kim, Chang Oh.

In: Archives of Gerontology and Geriatrics, Vol. 64, 01.05.2016, p. 51-58.

Research output: Contribution to journalArticle

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T1 - Serum uric acid concentration and metabolic syndrome among elderly Koreans

T2 - The Korean Urban Rural Elderly (KURE) study

AU - Choi, Hansol

AU - Kim, HyeonChang

AU - Song, Bo Mi

AU - Park, Ji Hye

AU - Lee, Ju Mi

AU - Yoon, Da Lim

AU - Yoon, Young Mi

AU - Rhee, Yumie

AU - Youm, Yoosik

AU - Kim, Chang Oh

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: Epidemiologic studies have demonstrated that elevated serum uric acid concentration is an independent risk factor for metabolic syndrome. However, few studies have focused on elderly populations. Thus, we investigated the association of serum uric acid concentration with metabolic syndrome in community-dwelling elderly Koreans. Methods: This cross-sectional analysis included 2940 participants (986 men and 1954 women) aged 65 years or older who participated in a baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2014. Serum uric acid concentration was analyzed using both continuous and dichotomous variables. Hyperuricemia was defined as a uric acid concentration ≥7.0 mg/dL in men and ≥6.0 mg/dL in women. Metabolic syndrome was defined according to the 2009 harmonizing definition. Multiple logistic regression models were used to investigate independent association between serum uric acid and metabolic syndrome, after adjusting for age, body mass index, LDL cholesterol, glycated hemoglobin, blood urea nitrogen, estimated glomerular filtration rate health behaviors, and medications. Results: Prevalence of metabolic syndrome and its components increased significantly according to uric acid concentration in both sexes. The adjusted odds ratios for having metabolic syndrome per 1.0 mg/dL higher uric acid concentration were 1.16 (95% CI: 1.03-1.31) in men and 1.27 (95% CI: 1.13-1.42) in women. Hyperuricemia was also associated with metabolic syndrome, with adjusted odds ratios of 1.71 (95% CI: 1.11-2.63) in men and 1.55 (95% CI: 1.05-2.29) in women. Conclusions: Elevated serum uric acid concentration was independently associated with an increased prevalence of metabolic syndrome in community-dwelling elderly Koreans.

AB - Background: Epidemiologic studies have demonstrated that elevated serum uric acid concentration is an independent risk factor for metabolic syndrome. However, few studies have focused on elderly populations. Thus, we investigated the association of serum uric acid concentration with metabolic syndrome in community-dwelling elderly Koreans. Methods: This cross-sectional analysis included 2940 participants (986 men and 1954 women) aged 65 years or older who participated in a baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2014. Serum uric acid concentration was analyzed using both continuous and dichotomous variables. Hyperuricemia was defined as a uric acid concentration ≥7.0 mg/dL in men and ≥6.0 mg/dL in women. Metabolic syndrome was defined according to the 2009 harmonizing definition. Multiple logistic regression models were used to investigate independent association between serum uric acid and metabolic syndrome, after adjusting for age, body mass index, LDL cholesterol, glycated hemoglobin, blood urea nitrogen, estimated glomerular filtration rate health behaviors, and medications. Results: Prevalence of metabolic syndrome and its components increased significantly according to uric acid concentration in both sexes. The adjusted odds ratios for having metabolic syndrome per 1.0 mg/dL higher uric acid concentration were 1.16 (95% CI: 1.03-1.31) in men and 1.27 (95% CI: 1.13-1.42) in women. Hyperuricemia was also associated with metabolic syndrome, with adjusted odds ratios of 1.71 (95% CI: 1.11-2.63) in men and 1.55 (95% CI: 1.05-2.29) in women. Conclusions: Elevated serum uric acid concentration was independently associated with an increased prevalence of metabolic syndrome in community-dwelling elderly Koreans.

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