Background/Aims: To investigate whether serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA+-M2BP) can predict the recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection. Methods: Patients with chronic hepatitis B (CHB) who underwent curative resection for HCC between 2004 and 2015 were eligible for the study. Recurrence was sub-classified as early (<2 years) or late (≥2 years). Results: A total of 170 patients with CHB were selected. During the follow-up period (median, 22.6 months), 64 (37.6%) patients developed recurrence. In multivariate analyses, WFA+-M2BP level was an independent predictor of overall (hazard ratio [HR]=1.490), early (HR=1.667), and late recurrence (HR=1.416), together with male sex, des-gamma carboxyprothrombin level, maximal tumor size, portal vein invasion, and satellite nodules (all P<0.05). However, WFA+-M2BP level was not predictive of grade B-C posthepatectomy liver failure. The cutoff value that maximized the sum of sensitivity (30.2%) and specificity (90.6%) was 2.14 (area under receiver operating characteristic curve=0.632, P=0.010). Patients with a WFA+-M2BP level >2.14 experienced recurrence more frequently than those with a WFA+-M2BP level ≤2.14 (P=0.011 by log-rank test), and had poorer postoperative outcomes than those with a WFA+-M2BP level ≤2.14 in terms of overall recurrence (56.0 vs. 34.5%, P=0.047) and early recurrence (52.0 vs. 20.7%, P=0.001). Conclusions: WFA+-M2BP level is an independent predictive factor of HBV-related HCC recurrence after curative resection. Further studies should investigate incorporation of WFA+-M2BP level into tailored postoperative surveillance strategies for patients with CHB.
Bibliographical noteFunding Information:
Graphics: The authors are grateful to Dong-Su Jang, (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine, Seoul, Korea) for his help with the figures. Writing assistance: The English in this document has been checked by at least two professional editors, both native speakers of English (www.textcheck.com). For a certificate, please see: http://www.textcheck.com/certificate/ESeGrC. This study was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Information and Communications Technology (ICT), and Future Planning (2016R1A1A1A05005138). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
This study was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Information and Communications Technology (ICT), and Future Planning (2016R1A1A1A05005138). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
© 2020 by Korean Association for the Study of the Liver.
All Science Journal Classification (ASJC) codes
- Molecular Biology