Investigation of antiinflammatory constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of three guaiane type sesquiterpenes, torilin, 1-hydroxytorilin, together with a new derivative, (1β, 7β, 8β, 10β)-1,8,11-trihydroxy-4-guaien-8-angeloyl-3-one named 1-hydroxytorilin A. All the three sesquiterpenes inhibited lipopolysaccharide-induced nitric oxide production in murine microglial BV2 cells.
Bibliographical noteFunding Information:
This research was supported by the Korea Research Foundation Grant (KRF-2003-015-E00216).
All Science Journal Classification (ASJC) codes
- Drug Discovery