Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production

Young Choong Kim, Mi Kyeong Lee, Sang Hyun Sung, Seung Hyun Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Investigation of antiinflammatory constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of three guaiane type sesquiterpenes, torilin, 1-hydroxytorilin, together with a new derivative, (1β, 7β, 8β, 10β)-1,8,11-trihydroxy-4-guaien-8-angeloyl-3-one named 1-hydroxytorilin A. All the three sesquiterpenes inhibited lipopolysaccharide-induced nitric oxide production in murine microglial BV2 cells.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalFitoterapia
Volume78
Issue number3
DOIs
Publication statusPublished - 2007 Apr 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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