Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production

Young Choong Kim, Mi Kyeong Lee, Sang Hyun Sung, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Investigation of antiinflammatory constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of three guaiane type sesquiterpenes, torilin, 1-hydroxytorilin, together with a new derivative, (1β, 7β, 8β, 10β)-1,8,11-trihydroxy-4-guaien-8-angeloyl-3-one named 1-hydroxytorilin A. All the three sesquiterpenes inhibited lipopolysaccharide-induced nitric oxide production in murine microglial BV2 cells.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalFitoterapia
Volume78
Issue number3
DOIs
Publication statusPublished - 2007 Apr

Bibliographical note

Funding Information:
This research was supported by the Korea Research Foundation Grant (KRF-2003-015-E00216).

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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