Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production

Young Choong Kim; Mi Kyeong Lee; Sang Hyun Sung; Seung Hyun Kim

doi:10.1016/j.fitote.2006.11.013

Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production

Young Choong Kim, Mi Kyeong Lee, Sang Hyun Sung, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Investigation of antiinflammatory constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of three guaiane type sesquiterpenes, torilin, 1-hydroxytorilin, together with a new derivative, (1β, 7β, 8β, 10β)-1,8,11-trihydroxy-4-guaien-8-angeloyl-3-one named 1-hydroxytorilin A. All the three sesquiterpenes inhibited lipopolysaccharide-induced nitric oxide production in murine microglial BV2 cells.

Original language	English
Pages (from-to)	196-199
Number of pages	4
Journal	Fitoterapia
Volume	78
Issue number	3
DOIs	https://doi.org/10.1016/j.fitote.2006.11.013
Publication status	Published - 2007 Apr

Bibliographical note

Funding Information:
This research was supported by the Korea Research Foundation Grant (KRF-2003-015-E00216).

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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10.1016/j.fitote.2006.11.013

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title = "Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production",

abstract = "Investigation of antiinflammatory constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of three guaiane type sesquiterpenes, torilin, 1-hydroxytorilin, together with a new derivative, (1β, 7β, 8β, 10β)-1,8,11-trihydroxy-4-guaien-8-angeloyl-3-one named 1-hydroxytorilin A. All the three sesquiterpenes inhibited lipopolysaccharide-induced nitric oxide production in murine microglial BV2 cells.",

author = "Kim, {Young Choong} and Lee, {Mi Kyeong} and Sung, {Sang Hyun} and Kim, {Seung Hyun}",

note = "Funding Information: This research was supported by the Korea Research Foundation Grant (KRF-2003-015-E00216).",

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AU - Sung, Sang Hyun

AU - Kim, Seung Hyun

N1 - Funding Information: This research was supported by the Korea Research Foundation Grant (KRF-2003-015-E00216).

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AB - Investigation of antiinflammatory constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of three guaiane type sesquiterpenes, torilin, 1-hydroxytorilin, together with a new derivative, (1β, 7β, 8β, 10β)-1,8,11-trihydroxy-4-guaien-8-angeloyl-3-one named 1-hydroxytorilin A. All the three sesquiterpenes inhibited lipopolysaccharide-induced nitric oxide production in murine microglial BV2 cells.

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Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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