Severe Fever with Thrombocytopenia Syndrome in South Korea, 2013-2015

Korea SFTS Clinical Network

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was recently identified in China, South Korea and Japan. The objective of the study was to evaluate the epidemiologic and clinical characteristics of SFTS in South Korea. Methods/Principal Findings: SFTS is a reportable disease in South Korea. We included all SFTS cases reported to the Korea Centers for Disease Control and Prevention (KCDC) from January 2013 to December 2015. Clinical information was gathered by reviewing medical records, and epidemiologic characteristics were analyzed using both KCDC surveillance data and patient medical records. Risk factors for mortality in patients with SFTS were assessed. A total of 172 SFTS cases were reported during the study period. SFTS occurred throughout the country, except in urban areas. Hilly areas in the eastern and southeastern regions and Jeju island (incidence, 1.26 cases /105person-years) were the main endemic areas. The yearly incidence increased from 36 cases in 2013 to 81 cases in 2015. Most cases occurred from May to October. The overall case fatality ratio was 32.6%. The clinical progression was similar to the 3 phases reported in China: fever, multi-organ dysfunction, and convalescence. Confusion, elevated C-reactive protein, and prolonged activated partial thromboplastin times were associated with mortality in patients with SFTS. Two outbreaks of nosocomial SFTS transmission were observed. Conclusions: SFTS is an endemic disease in South Korea, with a nationwide distribution and a high case-fatality ratio. Confusion, elevated levels of C-reactive protein, and prolonged activated partial thromboplastin times were associated with mortality in patients with SFTS.

Original languageEnglish
Article numbere0005264
JournalPLoS Neglected Tropical Diseases
Volume10
Issue number12
DOIs
Publication statusPublished - 2016 Dec 29

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Republic of Korea
Thrombocytopenia
Fever
Partial Thromboplastin Time
Centers for Disease Control and Prevention (U.S.)
Korea
C-Reactive Protein
Medical Records
Mortality
China
Emerging Communicable Diseases
Endemic Diseases
Incidence
Islands
Disease Outbreaks
Japan

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

@article{ffec6a6d5cdd4ed0ae032091126511a4,
title = "Severe Fever with Thrombocytopenia Syndrome in South Korea, 2013-2015",
abstract = "Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was recently identified in China, South Korea and Japan. The objective of the study was to evaluate the epidemiologic and clinical characteristics of SFTS in South Korea. Methods/Principal Findings: SFTS is a reportable disease in South Korea. We included all SFTS cases reported to the Korea Centers for Disease Control and Prevention (KCDC) from January 2013 to December 2015. Clinical information was gathered by reviewing medical records, and epidemiologic characteristics were analyzed using both KCDC surveillance data and patient medical records. Risk factors for mortality in patients with SFTS were assessed. A total of 172 SFTS cases were reported during the study period. SFTS occurred throughout the country, except in urban areas. Hilly areas in the eastern and southeastern regions and Jeju island (incidence, 1.26 cases /105person-years) were the main endemic areas. The yearly incidence increased from 36 cases in 2013 to 81 cases in 2015. Most cases occurred from May to October. The overall case fatality ratio was 32.6{\%}. The clinical progression was similar to the 3 phases reported in China: fever, multi-organ dysfunction, and convalescence. Confusion, elevated C-reactive protein, and prolonged activated partial thromboplastin times were associated with mortality in patients with SFTS. Two outbreaks of nosocomial SFTS transmission were observed. Conclusions: SFTS is an endemic disease in South Korea, with a nationwide distribution and a high case-fatality ratio. Confusion, elevated levels of C-reactive protein, and prolonged activated partial thromboplastin times were associated with mortality in patients with SFTS.",
author = "{Korea SFTS Clinical Network} and Choi, {Seong Jin} and Park, {Sang Won} and Bae, {In Gyu} and Kim, {Sung Han} and Ryu, {Seong Yeol} and Kim, {Hyun Ah} and Jang, {Hee Chang} and Jian Hur and Jun, {Jae Bum} and Younghee Jung and Chang, {Hyun Ha} and Kim, {Young Keun} and Jongyoun Yi and Kim, {Kye Hyung} and Hwang, {Jeong Hwan} and Kim, {Yeon Sook} and Jeong, {Hye Won} and Song, {Kyoung Ho} and Park, {Wan Beom} and Kim, {Eu Suk}",
year = "2016",
month = "12",
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language = "English",
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Severe Fever with Thrombocytopenia Syndrome in South Korea, 2013-2015. / Korea SFTS Clinical Network.

In: PLoS Neglected Tropical Diseases, Vol. 10, No. 12, e0005264, 29.12.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Severe Fever with Thrombocytopenia Syndrome in South Korea, 2013-2015

AU - Korea SFTS Clinical Network

AU - Choi, Seong Jin

AU - Park, Sang Won

AU - Bae, In Gyu

AU - Kim, Sung Han

AU - Ryu, Seong Yeol

AU - Kim, Hyun Ah

AU - Jang, Hee Chang

AU - Hur, Jian

AU - Jun, Jae Bum

AU - Jung, Younghee

AU - Chang, Hyun Ha

AU - Kim, Young Keun

AU - Yi, Jongyoun

AU - Kim, Kye Hyung

AU - Hwang, Jeong Hwan

AU - Kim, Yeon Sook

AU - Jeong, Hye Won

AU - Song, Kyoung Ho

AU - Park, Wan Beom

AU - Kim, Eu Suk

PY - 2016/12/29

Y1 - 2016/12/29

N2 - Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was recently identified in China, South Korea and Japan. The objective of the study was to evaluate the epidemiologic and clinical characteristics of SFTS in South Korea. Methods/Principal Findings: SFTS is a reportable disease in South Korea. We included all SFTS cases reported to the Korea Centers for Disease Control and Prevention (KCDC) from January 2013 to December 2015. Clinical information was gathered by reviewing medical records, and epidemiologic characteristics were analyzed using both KCDC surveillance data and patient medical records. Risk factors for mortality in patients with SFTS were assessed. A total of 172 SFTS cases were reported during the study period. SFTS occurred throughout the country, except in urban areas. Hilly areas in the eastern and southeastern regions and Jeju island (incidence, 1.26 cases /105person-years) were the main endemic areas. The yearly incidence increased from 36 cases in 2013 to 81 cases in 2015. Most cases occurred from May to October. The overall case fatality ratio was 32.6%. The clinical progression was similar to the 3 phases reported in China: fever, multi-organ dysfunction, and convalescence. Confusion, elevated C-reactive protein, and prolonged activated partial thromboplastin times were associated with mortality in patients with SFTS. Two outbreaks of nosocomial SFTS transmission were observed. Conclusions: SFTS is an endemic disease in South Korea, with a nationwide distribution and a high case-fatality ratio. Confusion, elevated levels of C-reactive protein, and prolonged activated partial thromboplastin times were associated with mortality in patients with SFTS.

AB - Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was recently identified in China, South Korea and Japan. The objective of the study was to evaluate the epidemiologic and clinical characteristics of SFTS in South Korea. Methods/Principal Findings: SFTS is a reportable disease in South Korea. We included all SFTS cases reported to the Korea Centers for Disease Control and Prevention (KCDC) from January 2013 to December 2015. Clinical information was gathered by reviewing medical records, and epidemiologic characteristics were analyzed using both KCDC surveillance data and patient medical records. Risk factors for mortality in patients with SFTS were assessed. A total of 172 SFTS cases were reported during the study period. SFTS occurred throughout the country, except in urban areas. Hilly areas in the eastern and southeastern regions and Jeju island (incidence, 1.26 cases /105person-years) were the main endemic areas. The yearly incidence increased from 36 cases in 2013 to 81 cases in 2015. Most cases occurred from May to October. The overall case fatality ratio was 32.6%. The clinical progression was similar to the 3 phases reported in China: fever, multi-organ dysfunction, and convalescence. Confusion, elevated C-reactive protein, and prolonged activated partial thromboplastin times were associated with mortality in patients with SFTS. Two outbreaks of nosocomial SFTS transmission were observed. Conclusions: SFTS is an endemic disease in South Korea, with a nationwide distribution and a high case-fatality ratio. Confusion, elevated levels of C-reactive protein, and prolonged activated partial thromboplastin times were associated with mortality in patients with SFTS.

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