Severe Vitamin D deficiency is a risk factor for renal hyperfiltration

Jong Hyun Jhee, Ki Heon Nam, Seong Yeong An, Min Uk Cha, Misol Lee, Seohyun Park, Hyoungnae Kim, Hae Ryong Yun, Youn Kyung Kee, Jung Tak Park, Seung Hyeok Han, Shin Wook Kang, Tae Hyun Yoo

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Background: Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population. Objective: We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Design: Data were retrieved from the Korean NHANES, a nationwide population-based cross-sectional study from 2008 to 2015. Overall, 33,210 subjects with normal renal function were included in the final analysis. Severe vitamin D deficiency was defined as serum 25-hydroxyvitamin D concentration <10 ng/mL. RHF was defined as estimated glomerular filtration rate with residual in the >95th percentile after adjustment for age, sex, height, weight, and history of hypertension or diabetes. Results: The mean ± SD age of subjects was 48.1 ± 15.9 y, and the number of women was 18,779 (56.5%). Estimated glomerular filtration rate was negatively associated with serum 25-hydroxyvitamin D concentrations in multivariable linear regression analysis (β: −0.02; 95% CI: −0.02, −0.01; P < 0.001). Furthermore, 1637 (4.9%) subjects were categorized into the RHF group, and the prevalence of RHF was significantly higher in the severe vitamin D deficiency group than in the sufficiency group (5.8% compared with 5.0%, P < 0.001). In a multivariable logistic regression model, severe vitamin D deficiency was a significant risk factor for RHF (OR: 2.41; 95% CI, 1.72, 3.43; P < 0.001). Conclusions: Severe vitamin D deficiency is significantly associated with increasing prevalence of RHF in a relatively healthy adult population.

Original languageEnglish
Pages (from-to)1342-1351
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Issue number6
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Jhee, J. H., Nam, K. H., An, S. Y., Cha, M. U., Lee, M., Park, S., Kim, H., Yun, H. R., Kee, Y. K., Park, J. T., Han, S. H., Kang, S. W., & Yoo, T. H. (2018). Severe Vitamin D deficiency is a risk factor for renal hyperfiltration. American Journal of Clinical Nutrition, 108(6), 1342-1351.