TY - JOUR
T1 - Sex difference in the effect of the fasting serum glucose level on the risk of coronary heart disease
AU - Ahn, Song Vogue
AU - Kim, Hyeon Chang
AU - Nam, Chung Mo
AU - Suh, Il
N1 - Publisher Copyright:
© 2017 Japanese College of Cardiology
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/2
Y1 - 2018/2
N2 - Objective Diabetic women have a greater relative risk of coronary heart disease than diabetic men. However, the sex difference in the effect of fasting serum glucose levels below the diabetic range on the risk of coronary heart disease is unclear. We investigated whether the association between nondiabetic blood glucose levels and the incident risk of coronary heart disease is different between men and women. Methods The fasting serum glucose levels and other cardiovascular risk factors at baseline were measured in 159,702 subjects (100,144 men and 59,558 women). Primary outcomes were hospital admission and death due to coronary heart disease during the 11-year follow-up. Results The risk for coronary heart disease in women significantly increased with impaired fasting glucose levels (≥110 mg/dL) compared to normal glucose levels (<100 mg/dL), whereas the risk for coronary heart disease in men was significantly increased at a diabetic glucose range (≥126 mg/dL). Women had a higher hazard ratio of coronary heart disease associated with the fasting serum glucose level than men (p for interaction with sex = 0.021). Conclusions The stronger effect of the fasting serum glucose levels on the risk of coronary heart disease in women than in men was significant from a prediabetic range (≥110 mg/dL).
AB - Objective Diabetic women have a greater relative risk of coronary heart disease than diabetic men. However, the sex difference in the effect of fasting serum glucose levels below the diabetic range on the risk of coronary heart disease is unclear. We investigated whether the association between nondiabetic blood glucose levels and the incident risk of coronary heart disease is different between men and women. Methods The fasting serum glucose levels and other cardiovascular risk factors at baseline were measured in 159,702 subjects (100,144 men and 59,558 women). Primary outcomes were hospital admission and death due to coronary heart disease during the 11-year follow-up. Results The risk for coronary heart disease in women significantly increased with impaired fasting glucose levels (≥110 mg/dL) compared to normal glucose levels (<100 mg/dL), whereas the risk for coronary heart disease in men was significantly increased at a diabetic glucose range (≥126 mg/dL). Women had a higher hazard ratio of coronary heart disease associated with the fasting serum glucose level than men (p for interaction with sex = 0.021). Conclusions The stronger effect of the fasting serum glucose levels on the risk of coronary heart disease in women than in men was significant from a prediabetic range (≥110 mg/dL).
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U2 - 10.1016/j.jjcc.2017.07.013
DO - 10.1016/j.jjcc.2017.07.013
M3 - Article
C2 - 28882397
AN - SCOPUS:85028734003
VL - 71
SP - 149
EP - 154
JO - Journal of Cardiology
JF - Journal of Cardiology
SN - 0914-5087
IS - 2
ER -