TY - JOUR
T1 - Sex differences in the relationship between blood mercury concentration and metabolic syndrome risk
AU - Chung, Ji Youn
AU - Seo, Min Seok
AU - Shim, Jae Yong
AU - Lee, Yong Jae
N1 - Publisher Copyright:
© Italian Society of Endocrinology (SIE) 2014.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background: Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered. Aim: To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women. Materials and methods: A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables. Results: Compared to the lowest quartile of blood mercury concentration, the OR (95% CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95% CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables. Conclusions: Blood mercury concentration was independently associated with an increased risk of MetS in men.
AB - Background: Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered. Aim: To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women. Materials and methods: A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables. Results: Compared to the lowest quartile of blood mercury concentration, the OR (95% CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95% CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables. Conclusions: Blood mercury concentration was independently associated with an increased risk of MetS in men.
UR - http://www.scopus.com/inward/record.url?scp=84923902427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923902427&partnerID=8YFLogxK
U2 - 10.1007/s40618-014-0132-3
DO - 10.1007/s40618-014-0132-3
M3 - Article
C2 - 25053396
AN - SCOPUS:84923902427
VL - 38
SP - 65
EP - 71
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 1
ER -