Sex differences in the relationship between blood mercury concentration and metabolic syndrome risk

Ji Youn Chung, Min Seok Seo, Jae Yong Shim, Yongjae Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered. Aim: To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women. Materials and methods: A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables. Results: Compared to the lowest quartile of blood mercury concentration, the OR (95% CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95% CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables. Conclusions: Blood mercury concentration was independently associated with an increased risk of MetS in men.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalJournal of Endocrinological Investigation
Volume38
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

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Mercury
Sex Characteristics
Logistic Models
Regression Analysis
Confounding Factors (Epidemiology)
Nutrition Surveys
Oxidants
Alcohol Drinking
Free Radicals
Cross-Sectional Studies
Smoking
Research Personnel
Exercise
Health
Enzymes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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title = "Sex differences in the relationship between blood mercury concentration and metabolic syndrome risk",
abstract = "Background: Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered. Aim: To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women. Materials and methods: A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables. Results: Compared to the lowest quartile of blood mercury concentration, the OR (95{\%} CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95{\%} CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables. Conclusions: Blood mercury concentration was independently associated with an increased risk of MetS in men.",
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Sex differences in the relationship between blood mercury concentration and metabolic syndrome risk. / Chung, Ji Youn; Seo, Min Seok; Shim, Jae Yong; Lee, Yongjae.

In: Journal of Endocrinological Investigation, Vol. 38, No. 1, 01.01.2015, p. 65-71.

Research output: Contribution to journalArticle

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AU - Shim, Jae Yong

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N2 - Background: Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered. Aim: To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women. Materials and methods: A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables. Results: Compared to the lowest quartile of blood mercury concentration, the OR (95% CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95% CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables. Conclusions: Blood mercury concentration was independently associated with an increased risk of MetS in men.

AB - Background: Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered. Aim: To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women. Materials and methods: A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables. Results: Compared to the lowest quartile of blood mercury concentration, the OR (95% CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95% CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables. Conclusions: Blood mercury concentration was independently associated with an increased risk of MetS in men.

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