Abstract
Background: Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered. Aim: To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women. Materials and methods: A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables. Results: Compared to the lowest quartile of blood mercury concentration, the OR (95% CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95% CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables. Conclusions: Blood mercury concentration was independently associated with an increased risk of MetS in men.
| Original language | English |
|---|---|
| Pages (from-to) | 65-71 |
| Number of pages | 7 |
| Journal | Journal of Endocrinological Investigation |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Sex differences in the relationship between blood mercury concentration and metabolic syndrome risk. / Chung, Ji Youn; Seo, Min Seok; Shim, Jae Yong; Lee, Yongjae.
In: Journal of Endocrinological Investigation, Vol. 38, No. 1, 01.01.2015, p. 65-71.Research output: Contribution to journal › Article
TY - JOUR
T1 - Sex differences in the relationship between blood mercury concentration and metabolic syndrome risk
AU - Chung, Ji Youn
AU - Seo, Min Seok
AU - Shim, Jae Yong
AU - Lee, Yongjae
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background: Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered. Aim: To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women. Materials and methods: A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables. Results: Compared to the lowest quartile of blood mercury concentration, the OR (95% CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95% CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables. Conclusions: Blood mercury concentration was independently associated with an increased risk of MetS in men.
AB - Background: Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered. Aim: To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women. Materials and methods: A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables. Results: Compared to the lowest quartile of blood mercury concentration, the OR (95% CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95% CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables. Conclusions: Blood mercury concentration was independently associated with an increased risk of MetS in men.
UR - http://www.scopus.com/inward/record.url?scp=84923902427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923902427&partnerID=8YFLogxK
U2 - 10.1007/s40618-014-0132-3
DO - 10.1007/s40618-014-0132-3
M3 - Article
C2 - 25053396
AN - SCOPUS:84923902427
VL - 38
SP - 65
EP - 71
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 1
ER -