Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer

Hae Won Kim, Jie-Hyun Kim, Beom Jin Lim, Hyun Ki Kim, Hoguen Kim, Jae Jun Park, Young Hoon Youn, HyoJin Park, Sung Hoon Noh, Jong Won Kim, Seung Ho Choi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze clinicopathological differences between sex groups to reveal sex disparities in GC. Methods: We retrospectively analyzed 4722 patients with GC who underwent gastrectomy (females: 1586 (33.6 %); males: 3136 (66.4 %), and analyzed clinicopathological features between these sex groups. The overall survival (OS) rate was investigated between the two sex groups, with special reference to the pathologic World Health Organization GC classifications. Immunohistochemistry staining of sex hormone receptors, including the estrogen receptor (ER)-α, ER-β, progesterone receptor, and androgen receptor, was performed according to sex and pathological classification. Results: Female patients were significantly associated with a younger age, poorly differentiated adenocarcinoma, and SRC compared with males. Female patients showed a significantly poorer OS than male patients, especially among those with advanced GC (AGC) aged ≤45 years. In females with AGC, those with SRC had a significantly poorer OS than those with other histologies. Moreover, the expression of ER-β was different between females and males with SRC. Conclusions: Females with GC were significantly younger and had a different SRC histology compared with males. Furthermore, females had significantly poorer prognostic factors among young patients with SRC. Thus, young female GC patients with SRC are a main target group in which to improve prognosis.

Original languageEnglish
Pages (from-to)4344-4351
Number of pages8
JournalAnnals of Surgical Oncology
Volume23
Issue number13
DOIs
Publication statusPublished - 2016 Dec 1

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Signet Ring Cell Carcinoma
Stomach Neoplasms
Estrogen Receptors
Sex Characteristics
Histology
Survival
Androgen Receptors
Gonadal Steroid Hormones
Progesterone Receptors
Gastrectomy
Adenocarcinoma
Survival Rate
Immunohistochemistry
Staining and Labeling
Incidence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Kim, Hae Won ; Kim, Jie-Hyun ; Lim, Beom Jin ; Kim, Hyun Ki ; Kim, Hoguen ; Park, Jae Jun ; Youn, Young Hoon ; Park, HyoJin ; Noh, Sung Hoon ; Kim, Jong Won ; Choi, Seung Ho. / Sex Disparity in Gastric Cancer : Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer. In: Annals of Surgical Oncology. 2016 ; Vol. 23, No. 13. pp. 4344-4351.
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title = "Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer",
abstract = "Background: The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze clinicopathological differences between sex groups to reveal sex disparities in GC. Methods: We retrospectively analyzed 4722 patients with GC who underwent gastrectomy (females: 1586 (33.6 {\%}); males: 3136 (66.4 {\%}), and analyzed clinicopathological features between these sex groups. The overall survival (OS) rate was investigated between the two sex groups, with special reference to the pathologic World Health Organization GC classifications. Immunohistochemistry staining of sex hormone receptors, including the estrogen receptor (ER)-α, ER-β, progesterone receptor, and androgen receptor, was performed according to sex and pathological classification. Results: Female patients were significantly associated with a younger age, poorly differentiated adenocarcinoma, and SRC compared with males. Female patients showed a significantly poorer OS than male patients, especially among those with advanced GC (AGC) aged ≤45 years. In females with AGC, those with SRC had a significantly poorer OS than those with other histologies. Moreover, the expression of ER-β was different between females and males with SRC. Conclusions: Females with GC were significantly younger and had a different SRC histology compared with males. Furthermore, females had significantly poorer prognostic factors among young patients with SRC. Thus, young female GC patients with SRC are a main target group in which to improve prognosis.",
author = "Kim, {Hae Won} and Jie-Hyun Kim and Lim, {Beom Jin} and Kim, {Hyun Ki} and Hoguen Kim and Park, {Jae Jun} and Youn, {Young Hoon} and HyoJin Park and Noh, {Sung Hoon} and Kim, {Jong Won} and Choi, {Seung Ho}",
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Kim, HW, Kim, J-H, Lim, BJ, Kim, HK, Kim, H, Park, JJ, Youn, YH, Park, H, Noh, SH, Kim, JW & Choi, SH 2016, 'Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer', Annals of Surgical Oncology, vol. 23, no. 13, pp. 4344-4351. https://doi.org/10.1245/s10434-016-5448-0

Sex Disparity in Gastric Cancer : Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer. / Kim, Hae Won; Kim, Jie-Hyun; Lim, Beom Jin; Kim, Hyun Ki; Kim, Hoguen; Park, Jae Jun; Youn, Young Hoon; Park, HyoJin; Noh, Sung Hoon; Kim, Jong Won; Choi, Seung Ho.

In: Annals of Surgical Oncology, Vol. 23, No. 13, 01.12.2016, p. 4344-4351.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sex Disparity in Gastric Cancer

T2 - Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer

AU - Kim, Hae Won

AU - Kim, Jie-Hyun

AU - Lim, Beom Jin

AU - Kim, Hyun Ki

AU - Kim, Hoguen

AU - Park, Jae Jun

AU - Youn, Young Hoon

AU - Park, HyoJin

AU - Noh, Sung Hoon

AU - Kim, Jong Won

AU - Choi, Seung Ho

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background: The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze clinicopathological differences between sex groups to reveal sex disparities in GC. Methods: We retrospectively analyzed 4722 patients with GC who underwent gastrectomy (females: 1586 (33.6 %); males: 3136 (66.4 %), and analyzed clinicopathological features between these sex groups. The overall survival (OS) rate was investigated between the two sex groups, with special reference to the pathologic World Health Organization GC classifications. Immunohistochemistry staining of sex hormone receptors, including the estrogen receptor (ER)-α, ER-β, progesterone receptor, and androgen receptor, was performed according to sex and pathological classification. Results: Female patients were significantly associated with a younger age, poorly differentiated adenocarcinoma, and SRC compared with males. Female patients showed a significantly poorer OS than male patients, especially among those with advanced GC (AGC) aged ≤45 years. In females with AGC, those with SRC had a significantly poorer OS than those with other histologies. Moreover, the expression of ER-β was different between females and males with SRC. Conclusions: Females with GC were significantly younger and had a different SRC histology compared with males. Furthermore, females had significantly poorer prognostic factors among young patients with SRC. Thus, young female GC patients with SRC are a main target group in which to improve prognosis.

AB - Background: The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze clinicopathological differences between sex groups to reveal sex disparities in GC. Methods: We retrospectively analyzed 4722 patients with GC who underwent gastrectomy (females: 1586 (33.6 %); males: 3136 (66.4 %), and analyzed clinicopathological features between these sex groups. The overall survival (OS) rate was investigated between the two sex groups, with special reference to the pathologic World Health Organization GC classifications. Immunohistochemistry staining of sex hormone receptors, including the estrogen receptor (ER)-α, ER-β, progesterone receptor, and androgen receptor, was performed according to sex and pathological classification. Results: Female patients were significantly associated with a younger age, poorly differentiated adenocarcinoma, and SRC compared with males. Female patients showed a significantly poorer OS than male patients, especially among those with advanced GC (AGC) aged ≤45 years. In females with AGC, those with SRC had a significantly poorer OS than those with other histologies. Moreover, the expression of ER-β was different between females and males with SRC. Conclusions: Females with GC were significantly younger and had a different SRC histology compared with males. Furthermore, females had significantly poorer prognostic factors among young patients with SRC. Thus, young female GC patients with SRC are a main target group in which to improve prognosis.

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