Sex hormones establish a reserve pool of adult muscle stem cells

Ji Hoon Kim, Gi Chan Han, Ji Yun Seo, Inkuk Park, Wookjin Park, Hyun Woo Jeong, Su Hyeon Lee, Sung Hwan Bae, Jinwoo Seong, Min Kyu Yum, Sang Hyeon Hann, Young-Guen Kwon, Daekwan Seo, Man Ho Choi, Young Yun Kong

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Quiescent satellite cells, known as adult muscle stem cells, possess a remarkable ability to regenerate skeletal muscle following injury throughout life. Although they mainly originate from multipotent stem/progenitor cells of the somite, the mechanism underlying the establishment of quiescent satellite cell populations is unknown. Here, we show that sex hormones induce Mind bomb 1 (Mib1) expression in myofibres at puberty, which activates Notch signalling in cycling juvenile satellite cells and causes them to be converted into adult quiescent satellite cells. Myofibres lacking Mib1 fail to send Notch signals to juvenile satellite cells, leading to impaired cell cycle exit and depletion. Our findings reveal that the hypothalamic-pituitary-gonadal axis drives Mib1 expression in the myofibre niche. Moreover, the same axis regulates the re-establishment of quiescent satellite cell populations following injury. Our data show that sex hormones establish adult quiescent satellite cell populations by regulating the myofibre niche at puberty and re-establish them during regeneration.

Original languageEnglish
Pages (from-to)930-940
Number of pages11
JournalNature Cell Biology
Volume18
Issue number9
DOIs
Publication statusPublished - 2016 Sep 1

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Adult Stem Cells
Gonadal Steroid Hormones
Muscle Cells
Bombs
Puberty
Multipotent Stem Cells
Population
Somites
Wounds and Injuries
Regeneration
Cell Cycle
Skeletal Muscle
Stem Cells

All Science Journal Classification (ASJC) codes

  • Cell Biology

Cite this

Kim, J. H., Han, G. C., Seo, J. Y., Park, I., Park, W., Jeong, H. W., ... Kong, Y. Y. (2016). Sex hormones establish a reserve pool of adult muscle stem cells. Nature Cell Biology, 18(9), 930-940. https://doi.org/10.1038/ncb3401
Kim, Ji Hoon ; Han, Gi Chan ; Seo, Ji Yun ; Park, Inkuk ; Park, Wookjin ; Jeong, Hyun Woo ; Lee, Su Hyeon ; Bae, Sung Hwan ; Seong, Jinwoo ; Yum, Min Kyu ; Hann, Sang Hyeon ; Kwon, Young-Guen ; Seo, Daekwan ; Choi, Man Ho ; Kong, Young Yun. / Sex hormones establish a reserve pool of adult muscle stem cells. In: Nature Cell Biology. 2016 ; Vol. 18, No. 9. pp. 930-940.
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Kim, JH, Han, GC, Seo, JY, Park, I, Park, W, Jeong, HW, Lee, SH, Bae, SH, Seong, J, Yum, MK, Hann, SH, Kwon, Y-G, Seo, D, Choi, MH & Kong, YY 2016, 'Sex hormones establish a reserve pool of adult muscle stem cells', Nature Cell Biology, vol. 18, no. 9, pp. 930-940. https://doi.org/10.1038/ncb3401

Sex hormones establish a reserve pool of adult muscle stem cells. / Kim, Ji Hoon; Han, Gi Chan; Seo, Ji Yun; Park, Inkuk; Park, Wookjin; Jeong, Hyun Woo; Lee, Su Hyeon; Bae, Sung Hwan; Seong, Jinwoo; Yum, Min Kyu; Hann, Sang Hyeon; Kwon, Young-Guen; Seo, Daekwan; Choi, Man Ho; Kong, Young Yun.

In: Nature Cell Biology, Vol. 18, No. 9, 01.09.2016, p. 930-940.

Research output: Contribution to journalArticle

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Kim JH, Han GC, Seo JY, Park I, Park W, Jeong HW et al. Sex hormones establish a reserve pool of adult muscle stem cells. Nature Cell Biology. 2016 Sep 1;18(9):930-940. https://doi.org/10.1038/ncb3401