Sex-specific metabolic interactions between liver and adipose tissue in MCD diet-induced non-alcoholic fatty liver disease

Yun-Hee Lee, Sou Hyun Kim, Sang Nam Kim, Hyun Jung Kwon, Jeong Dong Kim, Ji Youn Oh, Young Suk Jung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Higher susceptibility to metabolic disease in male exemplifies the importance of sexual dimorphism in pathogenesis. We hypothesized that the higher incidence of non-alcoholic fatty liver disease in males involves sex-specific metabolic interactions between liver and adipose tissue. In the present study, we used a methionine-choline deficient (MCD) diet-induced fatty liver mouse model to investigate sex differences in the metabolic response of the liver and adipose tissue. After 2 weeks on an MCD-diet, fatty liver was induced in a sex-specific manner, affecting male mice more severely than females. The MCD-diet increased lipolytic enzymes in the gonadal white adipose tissue (gWAT) of male mice, whereas it increased expression of uncoupling protein 1 and other brown adipocyte markers in the gWAT of female mice. Moreover, gWAT from female mice demonstrated higher levels of oxygen consumption and mitochondrial content compared to gWAT from male mice. FGF21 expression was increased in liver tissue by the MCD diet, and the degree of upregulation was significantly higher in the livers of female mice. The endocrine effect of FGF21 was responsible, in part, for the sex-specific browning of gonadal white adipose tissue. Collectively, these data demonstrated that distinctively female-specific browning of white adipose tissue aids in protecting female mice against MCD diet-induced fatty liver disease.

Original languageEnglish
Pages (from-to)46959-46971
Number of pages13
JournalOncotarget
Volume7
Issue number30
DOIs
Publication statusPublished - 2016 Jan 1

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Choline
Methionine
White Adipose Tissue
Adipose Tissue
Diet
Liver
Fatty Liver
Sex Characteristics
Brown Adipocytes
Non-alcoholic Fatty Liver Disease
Metabolic Diseases
Oxygen Consumption
Liver Diseases
Up-Regulation
Incidence
Enzymes

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Lee, Y-H., Kim, S. H., Kim, S. N., Kwon, H. J., Kim, J. D., Oh, J. Y., & Jung, Y. S. (2016). Sex-specific metabolic interactions between liver and adipose tissue in MCD diet-induced non-alcoholic fatty liver disease. Oncotarget, 7(30), 46959-46971. https://doi.org/10.18632/oncotarget.10506
Lee, Yun-Hee ; Kim, Sou Hyun ; Kim, Sang Nam ; Kwon, Hyun Jung ; Kim, Jeong Dong ; Oh, Ji Youn ; Jung, Young Suk. / Sex-specific metabolic interactions between liver and adipose tissue in MCD diet-induced non-alcoholic fatty liver disease. In: Oncotarget. 2016 ; Vol. 7, No. 30. pp. 46959-46971.
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Sex-specific metabolic interactions between liver and adipose tissue in MCD diet-induced non-alcoholic fatty liver disease. / Lee, Yun-Hee; Kim, Sou Hyun; Kim, Sang Nam; Kwon, Hyun Jung; Kim, Jeong Dong; Oh, Ji Youn; Jung, Young Suk.

In: Oncotarget, Vol. 7, No. 30, 01.01.2016, p. 46959-46971.

Research output: Contribution to journalArticle

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