The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.
Bibliographical noteFunding Information:
We thank Dr. Yun-Hee Choi and Anne Reuter (UT Southwestern Medical Center) for helpful discussions and suggestions. We also thank UTSW Mouse Metabolic Phenotyping Core (supported by PL1 DK081182 and UL1RR024923). This study was supported by National Institutes of Health grants RL1DK081185 (to J.K.E.).
All Science Journal Classification (ASJC) codes
- Molecular Biology