SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis

Ki Woo Kim, Jong Woo Sohn, Daisuke Kohno, Yong Xu, Kevin Williams, Joel K. Elmquist

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)

Abstract

The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume336
Issue number1-2
DOIs
Publication statusPublished - 2011 Apr 10

Bibliographical note

Funding Information:
We thank Dr. Yun-Hee Choi and Anne Reuter (UT Southwestern Medical Center) for helpful discussions and suggestions. We also thank UTSW Mouse Metabolic Phenotyping Core (supported by PL1 DK081182 and UL1RR024923). This study was supported by National Institutes of Health grants RL1DK081185 (to J.K.E.).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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