Shape changes of the basal ganglia and thalamus in Alzheimer's disease: A three-year longitudinal study

Hanna Cho, Jeong Hun Kim, Changsoo Kim, Byoung Seok Ye, Hee Jin Kim, Cindy W. Yoon, Young Noh, Geon Ha Kim, Yeo Jin Kim, Jung Hyun Kim, Chang Hun Kim, Sue J. Kang, Juhee Chin, Sung Tae Kim, Kyung Han Lee, Duk L. Na, Joon Kyung Seong, Sang Won Seo

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: A large number of Alzheimer's disease (AD) studies have focused on medial temporal and cortical atrophy, while changes in the basal ganglia or thalamus have received less attention. Objective: The aim of this study was to investigate the existence of progressive topographical shape changes in the basal ganglia (caudate nucleus, putamen, and globus pallidus) and thalamus concurrent with AD disease progression over three years. This study also examined whether declines in volumes of the basal ganglia or thalamus might be responsible for cognitive decline in patients with AD. Methods: Thirty-six patients with early stage AD and 14 normal control subjects were prospectively recruited for this study. All subjects were assessed with neuropsychological tests and MRI at baseline and Years 1 and 3. A longitudinal shape analysis of the basal ganglia and thalamus was performed by employing a boundary surface-based shape analysis method. Results: AD patients exhibited specific regional atrophy in the right caudate nucleus and the bilateral putamen at baseline, and as the disease progressed, regional atrophic changes in the left caudate nucleus were found to conform to a distinct topography after controlling the total brain volume. Volumetric decline of the caudate nucleus and putamen correlated with cognitive decline in frontal function after controlling for age, gender, education, follow-up years, and total brain volume changes. Conclusion: Our findings suggest that shape changes of the basal ganglia occurred regardless of whole brain atrophy as AD progressed and were also responsible for cognitive decline that was observed from the frontal function tests. Supplementary Tables. JAD132072-Suppl.pdf.

Original languageEnglish
Pages (from-to)285-295
Number of pages11
JournalJournal of Alzheimer's Disease
Volume40
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Basal Ganglia
Thalamus
Caudate Nucleus
Longitudinal Studies
Alzheimer Disease
Putamen
Atrophy
Brain
Globus Pallidus
Neuropsychological Tests
Disease Progression
Education
Cognitive Dysfunction

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Cho, Hanna ; Kim, Jeong Hun ; Kim, Changsoo ; Ye, Byoung Seok ; Kim, Hee Jin ; Yoon, Cindy W. ; Noh, Young ; Kim, Geon Ha ; Kim, Yeo Jin ; Kim, Jung Hyun ; Kim, Chang Hun ; Kang, Sue J. ; Chin, Juhee ; Kim, Sung Tae ; Lee, Kyung Han ; Na, Duk L. ; Seong, Joon Kyung ; Seo, Sang Won. / Shape changes of the basal ganglia and thalamus in Alzheimer's disease : A three-year longitudinal study. In: Journal of Alzheimer's Disease. 2014 ; Vol. 40, No. 2. pp. 285-295.
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abstract = "Background: A large number of Alzheimer's disease (AD) studies have focused on medial temporal and cortical atrophy, while changes in the basal ganglia or thalamus have received less attention. Objective: The aim of this study was to investigate the existence of progressive topographical shape changes in the basal ganglia (caudate nucleus, putamen, and globus pallidus) and thalamus concurrent with AD disease progression over three years. This study also examined whether declines in volumes of the basal ganglia or thalamus might be responsible for cognitive decline in patients with AD. Methods: Thirty-six patients with early stage AD and 14 normal control subjects were prospectively recruited for this study. All subjects were assessed with neuropsychological tests and MRI at baseline and Years 1 and 3. A longitudinal shape analysis of the basal ganglia and thalamus was performed by employing a boundary surface-based shape analysis method. Results: AD patients exhibited specific regional atrophy in the right caudate nucleus and the bilateral putamen at baseline, and as the disease progressed, regional atrophic changes in the left caudate nucleus were found to conform to a distinct topography after controlling the total brain volume. Volumetric decline of the caudate nucleus and putamen correlated with cognitive decline in frontal function after controlling for age, gender, education, follow-up years, and total brain volume changes. Conclusion: Our findings suggest that shape changes of the basal ganglia occurred regardless of whole brain atrophy as AD progressed and were also responsible for cognitive decline that was observed from the frontal function tests. Supplementary Tables. JAD132072-Suppl.pdf.",
author = "Hanna Cho and Kim, {Jeong Hun} and Changsoo Kim and Ye, {Byoung Seok} and Kim, {Hee Jin} and Yoon, {Cindy W.} and Young Noh and Kim, {Geon Ha} and Kim, {Yeo Jin} and Kim, {Jung Hyun} and Kim, {Chang Hun} and Kang, {Sue J.} and Juhee Chin and Kim, {Sung Tae} and Lee, {Kyung Han} and Na, {Duk L.} and Seong, {Joon Kyung} and Seo, {Sang Won}",
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Cho, H, Kim, JH, Kim, C, Ye, BS, Kim, HJ, Yoon, CW, Noh, Y, Kim, GH, Kim, YJ, Kim, JH, Kim, CH, Kang, SJ, Chin, J, Kim, ST, Lee, KH, Na, DL, Seong, JK & Seo, SW 2014, 'Shape changes of the basal ganglia and thalamus in Alzheimer's disease: A three-year longitudinal study', Journal of Alzheimer's Disease, vol. 40, no. 2, pp. 285-295. https://doi.org/10.3233/JAD-132072

Shape changes of the basal ganglia and thalamus in Alzheimer's disease : A three-year longitudinal study. / Cho, Hanna; Kim, Jeong Hun; Kim, Changsoo; Ye, Byoung Seok; Kim, Hee Jin; Yoon, Cindy W.; Noh, Young; Kim, Geon Ha; Kim, Yeo Jin; Kim, Jung Hyun; Kim, Chang Hun; Kang, Sue J.; Chin, Juhee; Kim, Sung Tae; Lee, Kyung Han; Na, Duk L.; Seong, Joon Kyung; Seo, Sang Won.

In: Journal of Alzheimer's Disease, Vol. 40, No. 2, 01.01.2014, p. 285-295.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Shape changes of the basal ganglia and thalamus in Alzheimer's disease

T2 - A three-year longitudinal study

AU - Cho, Hanna

AU - Kim, Jeong Hun

AU - Kim, Changsoo

AU - Ye, Byoung Seok

AU - Kim, Hee Jin

AU - Yoon, Cindy W.

AU - Noh, Young

AU - Kim, Geon Ha

AU - Kim, Yeo Jin

AU - Kim, Jung Hyun

AU - Kim, Chang Hun

AU - Kang, Sue J.

AU - Chin, Juhee

AU - Kim, Sung Tae

AU - Lee, Kyung Han

AU - Na, Duk L.

AU - Seong, Joon Kyung

AU - Seo, Sang Won

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: A large number of Alzheimer's disease (AD) studies have focused on medial temporal and cortical atrophy, while changes in the basal ganglia or thalamus have received less attention. Objective: The aim of this study was to investigate the existence of progressive topographical shape changes in the basal ganglia (caudate nucleus, putamen, and globus pallidus) and thalamus concurrent with AD disease progression over three years. This study also examined whether declines in volumes of the basal ganglia or thalamus might be responsible for cognitive decline in patients with AD. Methods: Thirty-six patients with early stage AD and 14 normal control subjects were prospectively recruited for this study. All subjects were assessed with neuropsychological tests and MRI at baseline and Years 1 and 3. A longitudinal shape analysis of the basal ganglia and thalamus was performed by employing a boundary surface-based shape analysis method. Results: AD patients exhibited specific regional atrophy in the right caudate nucleus and the bilateral putamen at baseline, and as the disease progressed, regional atrophic changes in the left caudate nucleus were found to conform to a distinct topography after controlling the total brain volume. Volumetric decline of the caudate nucleus and putamen correlated with cognitive decline in frontal function after controlling for age, gender, education, follow-up years, and total brain volume changes. Conclusion: Our findings suggest that shape changes of the basal ganglia occurred regardless of whole brain atrophy as AD progressed and were also responsible for cognitive decline that was observed from the frontal function tests. Supplementary Tables. JAD132072-Suppl.pdf.

AB - Background: A large number of Alzheimer's disease (AD) studies have focused on medial temporal and cortical atrophy, while changes in the basal ganglia or thalamus have received less attention. Objective: The aim of this study was to investigate the existence of progressive topographical shape changes in the basal ganglia (caudate nucleus, putamen, and globus pallidus) and thalamus concurrent with AD disease progression over three years. This study also examined whether declines in volumes of the basal ganglia or thalamus might be responsible for cognitive decline in patients with AD. Methods: Thirty-six patients with early stage AD and 14 normal control subjects were prospectively recruited for this study. All subjects were assessed with neuropsychological tests and MRI at baseline and Years 1 and 3. A longitudinal shape analysis of the basal ganglia and thalamus was performed by employing a boundary surface-based shape analysis method. Results: AD patients exhibited specific regional atrophy in the right caudate nucleus and the bilateral putamen at baseline, and as the disease progressed, regional atrophic changes in the left caudate nucleus were found to conform to a distinct topography after controlling the total brain volume. Volumetric decline of the caudate nucleus and putamen correlated with cognitive decline in frontal function after controlling for age, gender, education, follow-up years, and total brain volume changes. Conclusion: Our findings suggest that shape changes of the basal ganglia occurred regardless of whole brain atrophy as AD progressed and were also responsible for cognitive decline that was observed from the frontal function tests. Supplementary Tables. JAD132072-Suppl.pdf.

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