Shape control of cellulose nanocrystals via compositional acid hydrolysis

Changyoon Baek, Zahid Hanif, Seung-Woo Cho, Dong Ik Kim, Soong Ho Um

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The current medical technology has constantly demanded novel and advanced materials exhibiting the unique physico-chemical properties but, at the same time, possessing the intrinsic biocompatibility. Natural biomolecules based on materials such as peptide- (or protein-) or DNA/RNA derivatives have been formerly considered. To date, a carbohydrate-derived molecule has been a highlight as a substitute with the prior biomaterials, which suffer from their sequence-dependent immuno-cytoxicity. Of most, cellulose based materials have had a profound interest due to the great mechanical and optochemical properties as well as its immune-friendliness. However, it has been further manipulated in order to get distinctive structures at the desired shape and scale. Here, we report the versatile and synthetic technique to prepare spherical or rod-like cellulose nanocrystals (CNC). Under the varying concentrations of strong sulfuric acids (H2SO4) and hydrochloric acids (HCl), spherical or rod-typed CNCs were selectively manufactured via acid hydrolysis of microcrystalline celluloses (MCC) in massive bundles. At the sequential addition of H2SO4 and HCl in 1 to 2.5 molar ratios, most interestingly, the spherical CNC alone was observed with the average size of 50 nm in narrow distribution. All of CNCs had the larger surface area with mesoporosity. In addition, it was confirmed by the crystallographic measurement that it was very similar to the maternal structure originating from the bundle celluloses. It is much anticipated that the porous cellulose nanocrystals may play a principal role as a potential drug carrier for diseased biological compartments.

Original languageEnglish
Pages (from-to)1293-1298
Number of pages6
JournalJournal of Biomedical Nanotechnology
Volume9
Issue number7
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

Cellulose
Nanoparticles
Nanocrystals
Hydrolysis
Acids
Hydrochloric Acid
Hydrochloric acid
Sulfuric Acids
Drug Carriers
Biocompatible Materials
Biomolecules
Biocompatibility
Chemical properties
Carbohydrates
RNA
Sulfuric acid
Biomaterials
Peptides
Mothers
Technology

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Baek, Changyoon ; Hanif, Zahid ; Cho, Seung-Woo ; Kim, Dong Ik ; Um, Soong Ho. / Shape control of cellulose nanocrystals via compositional acid hydrolysis. In: Journal of Biomedical Nanotechnology. 2013 ; Vol. 9, No. 7. pp. 1293-1298.
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Shape control of cellulose nanocrystals via compositional acid hydrolysis. / Baek, Changyoon; Hanif, Zahid; Cho, Seung-Woo; Kim, Dong Ik; Um, Soong Ho.

In: Journal of Biomedical Nanotechnology, Vol. 9, No. 7, 01.07.2013, p. 1293-1298.

Research output: Contribution to journalArticle

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