Shape deformation of the insula in schizophrenia

Dong Pyo Jang, Jae-Jin Kim, Tae Sub Chung, Suk Kyoon An, Young Chul Jung, Jun Kee Lee, Jong Min Lee, In Young Kim, Sun I. kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Schizophrenia has been conceptualized to be a neurodevelopmental disorder. Neuroimaging evidence was generally findings of volumetric reductions in various brain structures. The shape analysis of the insula can uncover unique structural deformity in the neurodevelopmental disorder, which cannot be revealed from a simple volume measurement. The objective of this study was to demonstrate a subtle change of the insula in schizophrenia using our special shape analysis technique. Subjects were 23 patients with schizophrenia and 23 normal healthy subjects. A landmark-based structural and surface shape analysis of the insula was performed using high-spatial resolution magnetic resonance imaging. A characteristic finding was that the frontotemporal sides of the right insula were deformed in the patients with schizophrenia compared with normal controls. This deformation can be associated with abnormal development of the frontal and temporal lobes in schizophrenia.

Original languageEnglish
Pages (from-to)220-227
Number of pages8
JournalNeuroImage
Volume32
Issue number1
DOIs
Publication statusPublished - 2006 Jan 1

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Schizophrenia
Frontal Lobe
Temporal Lobe
Neuroimaging
Healthy Volunteers
Magnetic Resonance Imaging
Brain
Neurodevelopmental Disorders

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Jang, D. P., Kim, J-J., Chung, T. S., An, S. K., Jung, Y. C., Lee, J. K., ... kim, S. I. (2006). Shape deformation of the insula in schizophrenia. NeuroImage, 32(1), 220-227. https://doi.org/10.1016/j.neuroimage.2006.01.032
Jang, Dong Pyo ; Kim, Jae-Jin ; Chung, Tae Sub ; An, Suk Kyoon ; Jung, Young Chul ; Lee, Jun Kee ; Lee, Jong Min ; Kim, In Young ; kim, Sun I. / Shape deformation of the insula in schizophrenia. In: NeuroImage. 2006 ; Vol. 32, No. 1. pp. 220-227.
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Jang, DP, Kim, J-J, Chung, TS, An, SK, Jung, YC, Lee, JK, Lee, JM, Kim, IY & kim, SI 2006, 'Shape deformation of the insula in schizophrenia', NeuroImage, vol. 32, no. 1, pp. 220-227. https://doi.org/10.1016/j.neuroimage.2006.01.032

Shape deformation of the insula in schizophrenia. / Jang, Dong Pyo; Kim, Jae-Jin; Chung, Tae Sub; An, Suk Kyoon; Jung, Young Chul; Lee, Jun Kee; Lee, Jong Min; Kim, In Young; kim, Sun I.

In: NeuroImage, Vol. 32, No. 1, 01.01.2006, p. 220-227.

Research output: Contribution to journalArticle

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Jang DP, Kim J-J, Chung TS, An SK, Jung YC, Lee JK et al. Shape deformation of the insula in schizophrenia. NeuroImage. 2006 Jan 1;32(1):220-227. https://doi.org/10.1016/j.neuroimage.2006.01.032