Shear-wave elastography of invasive breast cancer

Correlation between quantitative mean elasticity value and immunohistochemical profile

Ji Hyun Youk, Hye Mi Gweon, Eun Ju Son, Jeong Ah Kim, Jeong Joon

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

To compare the mean elasticity value, as measured by shear-wave elastography (SWE), with immunohistochemical profile of invasive breast cancer. This was an institutional review board-approved retrospective study, with a waiver of informed consent. A total of 166 invasive breast cancers in 152 women undergoing preoperative SWE and surgery were included. Quantitative mean elasticity values in kPa were measured for each lesion by using SWE. Medical records were reviewed to determine palpability, invasive size, lymphovascular invasion, histologic grade, and axillary lymph node status. Based on the immunohistochemical profiles, tumor subtypes were categorized as triple-negative (TN), luminal A and B, or human epidermal growth factor receptor 2-enriched cancer. The mean elasticity value was correlated with clinicopathological features using univariate regression models and multivariate linear regression analysis. Palpability (P < 0.0001), larger size (P = 0.013), lymphovascular invasion (P < 0.0001), higher histologic grade (P < 0.0001), and lymph node involvement (P = 0.018) were significantly associated with the mean elasticity value. For the immunohistochemical profiles and tumor subtypes, the estrogen receptor (P = 0.015), progesterone receptor (P = 0.002), Ki-67 (P = 0.009), and the TN (P = 0.009) tumor subtype were correlated with the mean elasticity value. Multivariate logistic regression analysis showed that the following variables were significantly associated with the mean elasticity value: palpable abnormality, histologic grade, and lymphovascular invasion. No immunohistochemical profile of the cancers was independently correlated with the mean elasticity value. For invasive breast cancers, clinicopathological features of poor prognosis showed higher mean elasticity values than those of good prognosis. However, the immunohistochemical profile showed no independent association with the mean elasticity value.

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalBreast Cancer Research and Treatment
Volume138
Issue number1
DOIs
Publication statusPublished - 2013 Jan 16

Fingerprint

Elasticity Imaging Techniques
Elasticity
Breast Neoplasms
Neoplasms
Lymph Nodes
Regression Analysis
Research Ethics Committees
Progesterone Receptors
Informed Consent
Estrogen Receptors
Medical Records
Linear Models
Retrospective Studies
Logistic Models

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

@article{bd2309c7c2af4fdf87b1c302c9974824,
title = "Shear-wave elastography of invasive breast cancer: Correlation between quantitative mean elasticity value and immunohistochemical profile",
abstract = "To compare the mean elasticity value, as measured by shear-wave elastography (SWE), with immunohistochemical profile of invasive breast cancer. This was an institutional review board-approved retrospective study, with a waiver of informed consent. A total of 166 invasive breast cancers in 152 women undergoing preoperative SWE and surgery were included. Quantitative mean elasticity values in kPa were measured for each lesion by using SWE. Medical records were reviewed to determine palpability, invasive size, lymphovascular invasion, histologic grade, and axillary lymph node status. Based on the immunohistochemical profiles, tumor subtypes were categorized as triple-negative (TN), luminal A and B, or human epidermal growth factor receptor 2-enriched cancer. The mean elasticity value was correlated with clinicopathological features using univariate regression models and multivariate linear regression analysis. Palpability (P < 0.0001), larger size (P = 0.013), lymphovascular invasion (P < 0.0001), higher histologic grade (P < 0.0001), and lymph node involvement (P = 0.018) were significantly associated with the mean elasticity value. For the immunohistochemical profiles and tumor subtypes, the estrogen receptor (P = 0.015), progesterone receptor (P = 0.002), Ki-67 (P = 0.009), and the TN (P = 0.009) tumor subtype were correlated with the mean elasticity value. Multivariate logistic regression analysis showed that the following variables were significantly associated with the mean elasticity value: palpable abnormality, histologic grade, and lymphovascular invasion. No immunohistochemical profile of the cancers was independently correlated with the mean elasticity value. For invasive breast cancers, clinicopathological features of poor prognosis showed higher mean elasticity values than those of good prognosis. However, the immunohistochemical profile showed no independent association with the mean elasticity value.",
author = "Youk, {Ji Hyun} and Gweon, {Hye Mi} and Son, {Eun Ju} and Kim, {Jeong Ah} and Jeong Joon",
year = "2013",
month = "1",
day = "16",
doi = "10.1007/s10549-013-2407-3",
language = "English",
volume = "138",
pages = "119--126",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "1",

}

Shear-wave elastography of invasive breast cancer : Correlation between quantitative mean elasticity value and immunohistochemical profile. / Youk, Ji Hyun; Gweon, Hye Mi; Son, Eun Ju; Kim, Jeong Ah; Joon, Jeong.

In: Breast Cancer Research and Treatment, Vol. 138, No. 1, 16.01.2013, p. 119-126.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Shear-wave elastography of invasive breast cancer

T2 - Correlation between quantitative mean elasticity value and immunohistochemical profile

AU - Youk, Ji Hyun

AU - Gweon, Hye Mi

AU - Son, Eun Ju

AU - Kim, Jeong Ah

AU - Joon, Jeong

PY - 2013/1/16

Y1 - 2013/1/16

N2 - To compare the mean elasticity value, as measured by shear-wave elastography (SWE), with immunohistochemical profile of invasive breast cancer. This was an institutional review board-approved retrospective study, with a waiver of informed consent. A total of 166 invasive breast cancers in 152 women undergoing preoperative SWE and surgery were included. Quantitative mean elasticity values in kPa were measured for each lesion by using SWE. Medical records were reviewed to determine palpability, invasive size, lymphovascular invasion, histologic grade, and axillary lymph node status. Based on the immunohistochemical profiles, tumor subtypes were categorized as triple-negative (TN), luminal A and B, or human epidermal growth factor receptor 2-enriched cancer. The mean elasticity value was correlated with clinicopathological features using univariate regression models and multivariate linear regression analysis. Palpability (P < 0.0001), larger size (P = 0.013), lymphovascular invasion (P < 0.0001), higher histologic grade (P < 0.0001), and lymph node involvement (P = 0.018) were significantly associated with the mean elasticity value. For the immunohistochemical profiles and tumor subtypes, the estrogen receptor (P = 0.015), progesterone receptor (P = 0.002), Ki-67 (P = 0.009), and the TN (P = 0.009) tumor subtype were correlated with the mean elasticity value. Multivariate logistic regression analysis showed that the following variables were significantly associated with the mean elasticity value: palpable abnormality, histologic grade, and lymphovascular invasion. No immunohistochemical profile of the cancers was independently correlated with the mean elasticity value. For invasive breast cancers, clinicopathological features of poor prognosis showed higher mean elasticity values than those of good prognosis. However, the immunohistochemical profile showed no independent association with the mean elasticity value.

AB - To compare the mean elasticity value, as measured by shear-wave elastography (SWE), with immunohistochemical profile of invasive breast cancer. This was an institutional review board-approved retrospective study, with a waiver of informed consent. A total of 166 invasive breast cancers in 152 women undergoing preoperative SWE and surgery were included. Quantitative mean elasticity values in kPa were measured for each lesion by using SWE. Medical records were reviewed to determine palpability, invasive size, lymphovascular invasion, histologic grade, and axillary lymph node status. Based on the immunohistochemical profiles, tumor subtypes were categorized as triple-negative (TN), luminal A and B, or human epidermal growth factor receptor 2-enriched cancer. The mean elasticity value was correlated with clinicopathological features using univariate regression models and multivariate linear regression analysis. Palpability (P < 0.0001), larger size (P = 0.013), lymphovascular invasion (P < 0.0001), higher histologic grade (P < 0.0001), and lymph node involvement (P = 0.018) were significantly associated with the mean elasticity value. For the immunohistochemical profiles and tumor subtypes, the estrogen receptor (P = 0.015), progesterone receptor (P = 0.002), Ki-67 (P = 0.009), and the TN (P = 0.009) tumor subtype were correlated with the mean elasticity value. Multivariate logistic regression analysis showed that the following variables were significantly associated with the mean elasticity value: palpable abnormality, histologic grade, and lymphovascular invasion. No immunohistochemical profile of the cancers was independently correlated with the mean elasticity value. For invasive breast cancers, clinicopathological features of poor prognosis showed higher mean elasticity values than those of good prognosis. However, the immunohistochemical profile showed no independent association with the mean elasticity value.

UR - http://www.scopus.com/inward/record.url?scp=84874659463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874659463&partnerID=8YFLogxK

U2 - 10.1007/s10549-013-2407-3

DO - 10.1007/s10549-013-2407-3

M3 - Article

VL - 138

SP - 119

EP - 126

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 1

ER -