Short- and long-term seizure-free outcomes of dietary treatment in infants according to etiology

Igam Riantarini, HeungDong Kim, Ara Ko, Se Hee Kim, hoonchul kang, Joon Soo Lee, Da Eun Jung

Research output: Contribution to journalArticle

Abstract

Purpose: It is important to determine whether specific etiology is more effective to dietary treatment so that the diet can be started earlier for infants. We evaluated etiology-specific, seizure-free outcomes of dietary treatment in infants <1 year of age. Methods: We conducted a 10-year, retrospective, longitudinal observational study of 115 infants treated with ketogenic diet (KD) or modified Atkins diet (MAD). Results: Most patients (70%) received classical KD; 30% received MAD. During follow-up, 90%, 73%, and 61% of the patients remained on the diet at 3, 6, and 12 months, respectively. Seizure-free outcomes were reported in 50%, 44%, and 50% of the patients at 3, 6, and 12 months, respectively. Long-term seizure-free outcomes over 12 months were reported in 43 (74%) of 58 infants who were seizure-free at 3 months. Etiologies were mostly symptomatic (structural brain abnormalities, genetic, or metabolic) in 83 (72%) of 115 patients. According to underlying etiology, long-term seizure-free outcomes were observed in 14 (33%) of 42 patients with structural brain abnormalities, 7 (33%) of 21 with genetic etiologies, 7 (35%) of 20 with metabolic etiologies, and 15 (47%) of 32 with unknown etiologies. There were no etiology-based differences with respect to long-term seizure-free outcomes (P = 0.63). Conclusion: The high rate of long-term seizure-free outcomes can be predicted based on the seizure freedom at 3 months regardless of etiology. Early dietary treatment is beneficial, even in infants <1 year of age with specific symptomatic etiologies such as genetic, structural brain abnormalities, and metabolic etiology.

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalSeizure
Volume71
DOIs
Publication statusPublished - 2019 Oct 1

Fingerprint

Seizures
Ketogenic Diet
Carbohydrate-Restricted Diet
Brain
Diet
Observational Studies
Longitudinal Studies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Riantarini, Igam ; Kim, HeungDong ; Ko, Ara ; Kim, Se Hee ; kang, hoonchul ; Lee, Joon Soo ; Jung, Da Eun. / Short- and long-term seizure-free outcomes of dietary treatment in infants according to etiology. In: Seizure. 2019 ; Vol. 71. pp. 100-104.
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abstract = "Purpose: It is important to determine whether specific etiology is more effective to dietary treatment so that the diet can be started earlier for infants. We evaluated etiology-specific, seizure-free outcomes of dietary treatment in infants <1 year of age. Methods: We conducted a 10-year, retrospective, longitudinal observational study of 115 infants treated with ketogenic diet (KD) or modified Atkins diet (MAD). Results: Most patients (70{\%}) received classical KD; 30{\%} received MAD. During follow-up, 90{\%}, 73{\%}, and 61{\%} of the patients remained on the diet at 3, 6, and 12 months, respectively. Seizure-free outcomes were reported in 50{\%}, 44{\%}, and 50{\%} of the patients at 3, 6, and 12 months, respectively. Long-term seizure-free outcomes over 12 months were reported in 43 (74{\%}) of 58 infants who were seizure-free at 3 months. Etiologies were mostly symptomatic (structural brain abnormalities, genetic, or metabolic) in 83 (72{\%}) of 115 patients. According to underlying etiology, long-term seizure-free outcomes were observed in 14 (33{\%}) of 42 patients with structural brain abnormalities, 7 (33{\%}) of 21 with genetic etiologies, 7 (35{\%}) of 20 with metabolic etiologies, and 15 (47{\%}) of 32 with unknown etiologies. There were no etiology-based differences with respect to long-term seizure-free outcomes (P = 0.63). Conclusion: The high rate of long-term seizure-free outcomes can be predicted based on the seizure freedom at 3 months regardless of etiology. Early dietary treatment is beneficial, even in infants <1 year of age with specific symptomatic etiologies such as genetic, structural brain abnormalities, and metabolic etiology.",
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Short- and long-term seizure-free outcomes of dietary treatment in infants according to etiology. / Riantarini, Igam; Kim, HeungDong; Ko, Ara; Kim, Se Hee; kang, hoonchul; Lee, Joon Soo; Jung, Da Eun.

In: Seizure, Vol. 71, 01.10.2019, p. 100-104.

Research output: Contribution to journalArticle

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AU - Ko, Ara

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AU - Lee, Joon Soo

AU - Jung, Da Eun

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