Objective: Cerebral palsy (CP) is a disabling condition characterized by the motor impairment, which is difficult to be ameliorated. In the brain of infants with CP, there are persistent pathomechanisms including accentuated neuroinflammation. Since erythropoietin was demonstrated to have neuroprotective effect via anti-inflammatory and anti-apoptotic properties, we hypothesized that the administration of recombinant human EPO (rhEPO) could help children with CP, especially young infants. Materials and method: We investigated the therapeutic efficacy of rhEPO for infants with CP, who had been undergoing active rehabilitation in hospitalized setting to eliminate treatment bias. Twenty infants with CP were randomly divided into EPO or control group equally. We compared the changes in the Gross Motor Function Measure (GMFM) and the Bayley Scales of Infant Development-II (BSID-II) scores during one month of hospitalization between two groups. Results: The improvements after 1month on the GMFM A and GMFM total scores differed significantly between the groups (p=0.003, p=0.04, respectively). However, the changes after 6months were not different between the two groups. The scores of BSID-II did not show any differences at 1-month and 6-months post-treatment. Conclusion: These results indicated that rhEPO could have therapeutic efficacy for infants with CP during the active rehabilitation and anti-inflammation was suggested to be one of its therapeutic mechanisms.
Bibliographical noteFunding Information:
This study was supported by grants from the National Research Foundation ( NRF-2010-0020408 ) funded by the Ministry of Education, Science and Technology, Republic of Korea .
© 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Developmental Neuroscience
- Clinical Neurology