Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing prosthetic eye wearers: A pilot study

J. W. Han, J. S. Yoon, S. Y. Jang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


PurposeLong-standing prosthetic eye wearing induces ocular surface inflammation. We investigated the short-term effects of topical cyclosporine A 0.05% (Restasis) in patients with ocular discomfort resulting from long-standing prosthetic eye wearing.MethodsThis was a prospective, interventional case series. Patients who were unilateral prosthetic eye wearers over a period of 5 years were enrolled at a single institution from March to July 2013. The subjects were instructed to instill topical cyclosporine A 0.05% twice per day. Measurements were made pre-treatment and after 1 and 3 months of treatment. Outcome measures were the ocular symptom score, the lid margin abnormality score, the Schirmer test, and the tear meniscus amount, using Fourier-domain optical coherence tomography.ResultsIn total, 20 consecutive patients (mean age: 60.1 years, 8 males, 12 females) were included. Ocular symptoms were improved after treatment for 1 month in all patients (ocular symptom score pre-treatment 76.83 vs 46.75 after treatment; P<0.001). There was no statistically significant difference in lid margin abnormality score or tear meniscus amount. The Schirmer test results were improved after treatment for 3 months (pre- and after treatment, 6.70 vs 11.40; P<0.001).ConclusionsTopical cyclosporine A 0.05% showed a satisfactory effect in long-standing prosthetic eye wearers. Ocular symptoms were markedly relieved in all subjects after treatment for 1 month.

Original languageEnglish
Pages (from-to)1212-1217
Number of pages6
JournalEye (Basingstoke)
Issue number10
Publication statusPublished - 2014 Jan 1

Bibliographical note

Funding Information:
We gratefully acknowledge the statistical support of Ji Sung Lee, Biostatistician, Biostatistical Consulting Unit, and Soonchunhyang University Medical Center. This study was supported by the Soonchunhyang University Research fund.

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems

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