Short-term outcomes of endoscopic submucosal dissection in patients with early gastric cancer: A prospective multicenter cohort study

Il Ju Choi, Na Rae Lee, Sang Gyun Kim, Wan Sik Lee, Seun Ja Park, Jae J. Kim, Jun Haeng Lee, Jin Won Kwon, Seung Hee Park, Ji Hye You, Ji Hyun Kim, Chul Hyun Lim, Joo Young Cho, Gwang Ha Kim, Yong Chan Lee, Hwoon Yong Jung, Ji Young Kim, Hoon Jai Chun, Sang Yong Seol

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13 Citations (Scopus)

Abstract

Background/Aims: Endoscopic submucosal dissection (ESD) is an effective treatment for early gastric cancer (EGC) that has demonstrated a minimal risk of lymph node metastasis in retrospective studies. We sought to prospectively evaluate the short-term outcomes of ESD treatment in EGCs. Methods: A prospective multicenter cohort study of neoplasms 3 cm or less in diameter at endoscopic size evaluation was performed in 12 Korean ESD study grouprelated university hospitals and the National Cancer Center. Resected specimens were evaluated by the central pathologic review board. Results: A patient cohort (n=712) with a total of 737 EGCs was analyzed. The margin-free en bloc resection rate was 97.3%, and curative resection of 640 lesions (86.8%) was achieved. Lower curative resection rates were associated with lesions 2 to 3 cm in size prior to ESD compared with lesions 2 cm or less in size (78.6% vs 88.1%, respectively, p=0.009). Significant factors associated with noncurative resection were moderately or poorly differentiated histological type, posterior wall tumor location, tumor size larger than 3 cm, ulceration, and submucosal invasion. Delayed bleeding occurred in 49 patients (6.9%), and 12 patients (1.7%) exhibited perforations. Conclusions: ESD is an effective treatment with a high curative resection rate for EGCs that meets relatively conservative pre-ESD indications. Long-term survival outcomes should be evaluated in followup studies.

Original languageEnglish
Pages (from-to)739-748
Number of pages10
JournalGut and liver
Volume10
Issue number5
DOIs
Publication statusPublished - 2016 Sep

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All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Choi, I. J., Lee, N. R., Kim, S. G., Lee, W. S., Park, S. J., Kim, J. J., Lee, J. H., Kwon, J. W., Park, S. H., You, J. H., Kim, J. H., Lim, C. H., Cho, J. Y., Kim, G. H., Lee, Y. C., Jung, H. Y., Kim, J. Y., Chun, H. J., & Seol, S. Y. (2016). Short-term outcomes of endoscopic submucosal dissection in patients with early gastric cancer: A prospective multicenter cohort study. Gut and liver, 10(5), 739-748. https://doi.org/10.5009/gnl15466