Short-Term Outcomes of Laparoscopic Proximal Gastrectomy With DoubleTract Reconstruction Versus Laparoscopic Total Gastrectomy for Upper Early Gastric Cancer: A KLASS 05 Randomized Clinical Trial

Sun Hwi Hwang, Do Joong Park, Hyung Ho Kim, Woo Jin Hyung, Hoon Hur, Han Kwang Yang, Hyuk Joon Lee, Hyoung Il Kim, Seong Ho Kong, Young Woo Kim, Han Hong Lee, Beom Su Kim, Young Kyu Park, Young Joon Lee, Sang Hoon Ahn, In Seob Lee, Yun Suhk Suh, Ji Ho Park, Soyeon Ahn, Sang Uk Han

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DTR) is a function-preserving procedure performed for treating upper early gastric cancer (EGC). However, few studies have compared the outcomes of LPG-DTR with those of laparoscopic total gastrectomy (LTG). This study aimed at comparing the short-term outcomes of LPGDTR between LTG and upper EGC. Materials and Methods: For upper-third EGC, a multicenter, prospective, randomized trial was performed to compare those who underwent LPG-DTR with those who underwent LTG. Short-term outcomes, including clinicopathologic results, morbidity, mortality, and postoperative courses, were evaluated using a full analysis set based on the intention-to-treat principle and the per-protocol set.Results: Of the patients, 138 who fulfilled the criteria were randomized to each group. One patient in the LPG-DTR group withdrew consent. Sixty-eight patients underwent LPGDTR and 69 underwent LTG. The operative time (LPG-DTR=219.4 minutes; LTG=201.8 minutes; P=0.085), estimated blood loss (LPG-DTR=76.0 mL; LTG=66.1 mL; P=0.413), and the morbidity rate (LPG-DTR=23.5%; LTG=17.4%; P=0.373) between the groups were not significantly different. No mortality occurred in either of the study groups. Two weeks post operation, the Visick scores for postprandial symptoms, including reflux symptoms, were not significantly different between the groups (P=0.749). Laboratory findings on postoperative day 5 were not significantly different between the groups. Conclusions: The short-term outcomes of LPG-DTR for upper EGC were comparable to those of LTG. Trial Registration: ClinicalTrials.gov Identifier: NCT02892643.

Original languageEnglish
Pages (from-to)94-106
Number of pages13
JournalJournal of Gastric Cancer
Volume22
Issue number2
DOIs
Publication statusPublished - 2022 Apr

Bibliographical note

Funding Information:
This study was funded by a research grant from Medtronic.

Publisher Copyright:
© 2022. Korean Gastric Cancer Association.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Gastroenterology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Short-Term Outcomes of Laparoscopic Proximal Gastrectomy With DoubleTract Reconstruction Versus Laparoscopic Total Gastrectomy for Upper Early Gastric Cancer: A KLASS 05 Randomized Clinical Trial'. Together they form a unique fingerprint.

Cite this