Signaling pathways downstream of pattern-recognition receptors and their cross talk

Myeong Sup Lee, Young Joon Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

562 Citations (Scopus)

Abstract

Pattern-recognition receptors (PRRs) initiate innate immunity through pathogen recognition. Serum PRRs opsonize pathogens for enhanced phagocytic clearance. Toll-like receptors (TLRs) initiate common NF-κB/AP-1 and distinct IRF3/7 pathways to coordinate innate immunity and to initiate adaptive immunity against diverse pathogens. Cytoplasmic caspase-recruiting domain (CARD) heli- cases, such as RIG-I/MDA5, mediate antiviral immunity by inducing the production of type I interferons via the adaptor IPS-1, whereas nucleotide-binding oligomerization domain (NOD)-like receptors mediate mainly antibacterial immunity by activating NF-κB or in- flammasomes. Dectin-1 is important for antifungal immunity, promoting phagocytosis and activating NF-κB. Potentially harmful TLR signaling pathways can be negatively regulated by negative feedback mechanisms and also by anti-inflammatory factors such as TGFβp, interleukin (IL)-10, and steroids. Many combinations of TLR-TLR and TLR-NOD modulate inflammatory responses. TLRs and NALP3 interplay to produce mature IL-1|β. Thus signaling pathways downstream of PRRs and their cross talk control immune responses in effective manners.

Original languageEnglish
Title of host publicationAnnual Review of Biochemistry
Pages447-480
Number of pages34
DOIs
Publication statusPublished - 2007

Publication series

NameAnnual Review of Biochemistry
Volume76
ISSN (Print)0066-4154
ISSN (Electronic)0066-4154

All Science Journal Classification (ASJC) codes

  • Biochemistry

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