Signaling pathways downstream of pattern-recognition receptors and their cross talk

Myeong Sup Lee, Young-Joon Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

488 Citations (Scopus)

Abstract

Pattern-recognition receptors (PRRs) initiate innate immunity through pathogen recognition. Serum PRRs opsonize pathogens for enhanced phagocytic clearance. Toll-like receptors (TLRs) initiate common NF-κB/AP-1 and distinct IRF3/7 pathways to coordinate innate immunity and to initiate adaptive immunity against diverse pathogens. Cytoplasmic caspase-recruiting domain (CARD) heli- cases, such as RIG-I/MDA5, mediate antiviral immunity by inducing the production of type I interferons via the adaptor IPS-1, whereas nucleotide-binding oligomerization domain (NOD)-like receptors mediate mainly antibacterial immunity by activating NF-κB or in- flammasomes. Dectin-1 is important for antifungal immunity, promoting phagocytosis and activating NF-κB. Potentially harmful TLR signaling pathways can be negatively regulated by negative feedback mechanisms and also by anti-inflammatory factors such as TGFβp, interleukin (IL)-10, and steroids. Many combinations of TLR-TLR and TLR-NOD modulate inflammatory responses. TLRs and NALP3 interplay to produce mature IL-1|β. Thus signaling pathways downstream of PRRs and their cross talk control immune responses in effective manners.

Original languageEnglish
Title of host publicationAnnual Review of Biochemistry
Pages447-480
Number of pages34
DOIs
Publication statusPublished - 2007 Dec 1

Publication series

NameAnnual Review of Biochemistry
Volume76
ISSN (Print)0066-4154
ISSN (Electronic)0066-4154

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Receptor Cross-Talk
Pattern Recognition Receptors
Toll-Like Receptors
Pathogens
Immunity
Oligomerization
Innate Immunity
Nucleotides
Inflammasomes
Interferon Type I
Transcription Factor AP-1
Adaptive Immunity
Caspases
Interleukin-1
Phagocytosis
Interleukin-10
Antiviral Agents
Anti-Inflammatory Agents
Steroids
Feedback

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Lee, M. S., & Kim, Y-J. (2007). Signaling pathways downstream of pattern-recognition receptors and their cross talk. In Annual Review of Biochemistry (pp. 447-480). (Annual Review of Biochemistry; Vol. 76). https://doi.org/10.1146/annurev.biochem.76.060605.122847
Lee, Myeong Sup ; Kim, Young-Joon. / Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annual Review of Biochemistry. 2007. pp. 447-480 (Annual Review of Biochemistry).
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Lee, MS & Kim, Y-J 2007, Signaling pathways downstream of pattern-recognition receptors and their cross talk. in Annual Review of Biochemistry. Annual Review of Biochemistry, vol. 76, pp. 447-480. https://doi.org/10.1146/annurev.biochem.76.060605.122847

Signaling pathways downstream of pattern-recognition receptors and their cross talk. / Lee, Myeong Sup; Kim, Young-Joon.

Annual Review of Biochemistry. 2007. p. 447-480 (Annual Review of Biochemistry; Vol. 76).

Research output: Chapter in Book/Report/Conference proceedingChapter

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