Significance of metabolic tumor volume and total lesion glycolysis measured using18F-FDG PET/CT in locally advanced and metastatic gallbladder carcinoma

You Jin Chun, Hei Cheul Jeung, Hyung Soon Park, Ji Soo Park, Sun Young Rha, Hye Jin Choi, Jae Hoon Lee, Tae Joo Jeon

Research output: Contribution to journalArticle

Abstract

Purpose: This study aimed to determine the prognostic value of new quantitative parameters of18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), including metabolic tumor volume (MTV), in patients with locally advanced and metastatic gallbladder cancer (GBC). Materials and Methods: In total, 83 patients initially diagnosed with locally advanced and metastatic GBC and who underwent18F-FDG PET/CT at the time of initial diagnosis were retrospectively reviewed. The metabolic volume-based PET parameters of primary tumors and metastatic lesions were measured, including maximum and average standardized uptake values (SUV), MTV, and total lesion glycolysis. An overall survival (OS) analysis was performed using the Kaplan-Meier method with PET and clinical parameters. A Cox proportional hazards regression analysis was performed to determine independent prognostic factors. Results: In univariate analysis, pathologic differentiation (p<0.001), performance status (PS; p=0.003), C-reactive protein (CRP) level (p=0.009), and PET-related SUVmt max (the highest SUV among the metastatic lesions) (p=0.040) and MTVtotal (the sum of the MTVs of both the primary and metastatic lesions) (p=0.031), were significant for OS. In multivariate analysis, MTVtotal (hazard ratio: 2.07; 95% confidence interval: 1.23–3.48; p=0.006) remained significant for the prediction of OS, as did differentiation (p=0.001), PS (p=0.001), and CRP (p=0.039). Conclusion: In locally advanced and metastatic GBC, volume-based PET/CT parameters of the total tumor burden of malignancy, such as MTVtotal, were found to be useful for the identification of patients with poor prognosis.

Original languageEnglish
Pages (from-to)604-610
Number of pages7
JournalYonsei medical journal
Volume60
Issue number7
DOIs
Publication statusPublished - 2019 Jul

Fingerprint

Gallbladder Neoplasms
Glycolysis
Gallbladder
Tumor Burden
Carcinoma
C-Reactive Protein
Survival
Fluorodeoxyglucose F18
Survival Analysis
Neoplasms
Multivariate Analysis
Regression Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chun, You Jin ; Jeung, Hei Cheul ; Park, Hyung Soon ; Park, Ji Soo ; Rha, Sun Young ; Choi, Hye Jin ; Lee, Jae Hoon ; Jeon, Tae Joo. / Significance of metabolic tumor volume and total lesion glycolysis measured using18F-FDG PET/CT in locally advanced and metastatic gallbladder carcinoma. In: Yonsei medical journal. 2019 ; Vol. 60, No. 7. pp. 604-610.
@article{7a94f405c2b34da3aa5456d32067644f,
title = "Significance of metabolic tumor volume and total lesion glycolysis measured using18F-FDG PET/CT in locally advanced and metastatic gallbladder carcinoma",
abstract = "Purpose: This study aimed to determine the prognostic value of new quantitative parameters of18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), including metabolic tumor volume (MTV), in patients with locally advanced and metastatic gallbladder cancer (GBC). Materials and Methods: In total, 83 patients initially diagnosed with locally advanced and metastatic GBC and who underwent18F-FDG PET/CT at the time of initial diagnosis were retrospectively reviewed. The metabolic volume-based PET parameters of primary tumors and metastatic lesions were measured, including maximum and average standardized uptake values (SUV), MTV, and total lesion glycolysis. An overall survival (OS) analysis was performed using the Kaplan-Meier method with PET and clinical parameters. A Cox proportional hazards regression analysis was performed to determine independent prognostic factors. Results: In univariate analysis, pathologic differentiation (p<0.001), performance status (PS; p=0.003), C-reactive protein (CRP) level (p=0.009), and PET-related SUVmt max (the highest SUV among the metastatic lesions) (p=0.040) and MTVtotal (the sum of the MTVs of both the primary and metastatic lesions) (p=0.031), were significant for OS. In multivariate analysis, MTVtotal (hazard ratio: 2.07; 95{\%} confidence interval: 1.23–3.48; p=0.006) remained significant for the prediction of OS, as did differentiation (p=0.001), PS (p=0.001), and CRP (p=0.039). Conclusion: In locally advanced and metastatic GBC, volume-based PET/CT parameters of the total tumor burden of malignancy, such as MTVtotal, were found to be useful for the identification of patients with poor prognosis.",
author = "Chun, {You Jin} and Jeung, {Hei Cheul} and Park, {Hyung Soon} and Park, {Ji Soo} and Rha, {Sun Young} and Choi, {Hye Jin} and Lee, {Jae Hoon} and Jeon, {Tae Joo}",
year = "2019",
month = "7",
doi = "10.3349/ymj.2019.60.7.604",
language = "English",
volume = "60",
pages = "604--610",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "7",

}

Significance of metabolic tumor volume and total lesion glycolysis measured using18F-FDG PET/CT in locally advanced and metastatic gallbladder carcinoma. / Chun, You Jin; Jeung, Hei Cheul; Park, Hyung Soon; Park, Ji Soo; Rha, Sun Young; Choi, Hye Jin; Lee, Jae Hoon; Jeon, Tae Joo.

In: Yonsei medical journal, Vol. 60, No. 7, 07.2019, p. 604-610.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Significance of metabolic tumor volume and total lesion glycolysis measured using18F-FDG PET/CT in locally advanced and metastatic gallbladder carcinoma

AU - Chun, You Jin

AU - Jeung, Hei Cheul

AU - Park, Hyung Soon

AU - Park, Ji Soo

AU - Rha, Sun Young

AU - Choi, Hye Jin

AU - Lee, Jae Hoon

AU - Jeon, Tae Joo

PY - 2019/7

Y1 - 2019/7

N2 - Purpose: This study aimed to determine the prognostic value of new quantitative parameters of18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), including metabolic tumor volume (MTV), in patients with locally advanced and metastatic gallbladder cancer (GBC). Materials and Methods: In total, 83 patients initially diagnosed with locally advanced and metastatic GBC and who underwent18F-FDG PET/CT at the time of initial diagnosis were retrospectively reviewed. The metabolic volume-based PET parameters of primary tumors and metastatic lesions were measured, including maximum and average standardized uptake values (SUV), MTV, and total lesion glycolysis. An overall survival (OS) analysis was performed using the Kaplan-Meier method with PET and clinical parameters. A Cox proportional hazards regression analysis was performed to determine independent prognostic factors. Results: In univariate analysis, pathologic differentiation (p<0.001), performance status (PS; p=0.003), C-reactive protein (CRP) level (p=0.009), and PET-related SUVmt max (the highest SUV among the metastatic lesions) (p=0.040) and MTVtotal (the sum of the MTVs of both the primary and metastatic lesions) (p=0.031), were significant for OS. In multivariate analysis, MTVtotal (hazard ratio: 2.07; 95% confidence interval: 1.23–3.48; p=0.006) remained significant for the prediction of OS, as did differentiation (p=0.001), PS (p=0.001), and CRP (p=0.039). Conclusion: In locally advanced and metastatic GBC, volume-based PET/CT parameters of the total tumor burden of malignancy, such as MTVtotal, were found to be useful for the identification of patients with poor prognosis.

AB - Purpose: This study aimed to determine the prognostic value of new quantitative parameters of18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), including metabolic tumor volume (MTV), in patients with locally advanced and metastatic gallbladder cancer (GBC). Materials and Methods: In total, 83 patients initially diagnosed with locally advanced and metastatic GBC and who underwent18F-FDG PET/CT at the time of initial diagnosis were retrospectively reviewed. The metabolic volume-based PET parameters of primary tumors and metastatic lesions were measured, including maximum and average standardized uptake values (SUV), MTV, and total lesion glycolysis. An overall survival (OS) analysis was performed using the Kaplan-Meier method with PET and clinical parameters. A Cox proportional hazards regression analysis was performed to determine independent prognostic factors. Results: In univariate analysis, pathologic differentiation (p<0.001), performance status (PS; p=0.003), C-reactive protein (CRP) level (p=0.009), and PET-related SUVmt max (the highest SUV among the metastatic lesions) (p=0.040) and MTVtotal (the sum of the MTVs of both the primary and metastatic lesions) (p=0.031), were significant for OS. In multivariate analysis, MTVtotal (hazard ratio: 2.07; 95% confidence interval: 1.23–3.48; p=0.006) remained significant for the prediction of OS, as did differentiation (p=0.001), PS (p=0.001), and CRP (p=0.039). Conclusion: In locally advanced and metastatic GBC, volume-based PET/CT parameters of the total tumor burden of malignancy, such as MTVtotal, were found to be useful for the identification of patients with poor prognosis.

UR - http://www.scopus.com/inward/record.url?scp=85068972279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068972279&partnerID=8YFLogxK

U2 - 10.3349/ymj.2019.60.7.604

DO - 10.3349/ymj.2019.60.7.604

M3 - Article

C2 - 31250573

AN - SCOPUS:85068972279

VL - 60

SP - 604

EP - 610

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 7

ER -