Significance of sonographic characterization for managing subcentimeter thyroid nodules

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Ultrasonography (US) is increasingly able to detect thyroid nodules, and the differentiation between malignant and benign nodules has been raising issues among both clinicians and patients, especially patients with non-palpable small nodules. It is important to diagnose thyroid cancer at an early stage, because it may reduce the risk of disease recurrence and possible mortality. Purpose: To evaluate the diagnostic accuracy of malignant sonographic features of subcentimeter thyroid nodules. Material and Methods: This study examined 815 subcentimeter thyroid nodules in 815 patients. A final diagnosis was determined using fine-needle aspiration biopsy (FNAB) or postoperative pathologic findings. Logistic regression tests were used to evaluate statistical relationships between US findings and thyroid carcinoma. Results: Of 534 lesions that showed suspicious US findings, 472 (88.4%) revealed malignancy upon cytopathology. Two hundred eighty-one lesions showed probably benign findings on US, and only 23 (8.2%) were malignant. Sensitivity, specificity, positive predictive value, and negative predictive value of US were 95.4%, 80.6%, 88.4%, and 91.8%, respectively. There was a significant difference between the two US groups in the percentages of malignancy, according to logistic regression analysis. Conclusion: Our results demonstrate that this system of US classification can efficiently differentiate malignant subcentimeter nodules from benign nodules. Suspicious sonographic features can be useful criteria to decide whether a nodule should receive FNAB.

Original languageEnglish
Pages (from-to)917-923
Number of pages7
JournalActa Radiologica
Volume50
Issue number8
DOIs
Publication statusPublished - 2009 Oct 21

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Thyroid Nodule
Ultrasonography
Fine Needle Biopsy
Thyroid Neoplasms
Logistic Models
Neoplasms
Regression Analysis
Recurrence
Sensitivity and Specificity
Mortality

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Significance of sonographic characterization for managing subcentimeter thyroid nodules",
abstract = "Background: Ultrasonography (US) is increasingly able to detect thyroid nodules, and the differentiation between malignant and benign nodules has been raising issues among both clinicians and patients, especially patients with non-palpable small nodules. It is important to diagnose thyroid cancer at an early stage, because it may reduce the risk of disease recurrence and possible mortality. Purpose: To evaluate the diagnostic accuracy of malignant sonographic features of subcentimeter thyroid nodules. Material and Methods: This study examined 815 subcentimeter thyroid nodules in 815 patients. A final diagnosis was determined using fine-needle aspiration biopsy (FNAB) or postoperative pathologic findings. Logistic regression tests were used to evaluate statistical relationships between US findings and thyroid carcinoma. Results: Of 534 lesions that showed suspicious US findings, 472 (88.4{\%}) revealed malignancy upon cytopathology. Two hundred eighty-one lesions showed probably benign findings on US, and only 23 (8.2{\%}) were malignant. Sensitivity, specificity, positive predictive value, and negative predictive value of US were 95.4{\%}, 80.6{\%}, 88.4{\%}, and 91.8{\%}, respectively. There was a significant difference between the two US groups in the percentages of malignancy, according to logistic regression analysis. Conclusion: Our results demonstrate that this system of US classification can efficiently differentiate malignant subcentimeter nodules from benign nodules. Suspicious sonographic features can be useful criteria to decide whether a nodule should receive FNAB.",
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Significance of sonographic characterization for managing subcentimeter thyroid nodules. / Kwak, Jin Young; Kim, Eun Kyung; Kim, Min Jung; Son, Eun Ju.

In: Acta Radiologica, Vol. 50, No. 8, 21.10.2009, p. 917-923.

Research output: Contribution to journalArticle

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N2 - Background: Ultrasonography (US) is increasingly able to detect thyroid nodules, and the differentiation between malignant and benign nodules has been raising issues among both clinicians and patients, especially patients with non-palpable small nodules. It is important to diagnose thyroid cancer at an early stage, because it may reduce the risk of disease recurrence and possible mortality. Purpose: To evaluate the diagnostic accuracy of malignant sonographic features of subcentimeter thyroid nodules. Material and Methods: This study examined 815 subcentimeter thyroid nodules in 815 patients. A final diagnosis was determined using fine-needle aspiration biopsy (FNAB) or postoperative pathologic findings. Logistic regression tests were used to evaluate statistical relationships between US findings and thyroid carcinoma. Results: Of 534 lesions that showed suspicious US findings, 472 (88.4%) revealed malignancy upon cytopathology. Two hundred eighty-one lesions showed probably benign findings on US, and only 23 (8.2%) were malignant. Sensitivity, specificity, positive predictive value, and negative predictive value of US were 95.4%, 80.6%, 88.4%, and 91.8%, respectively. There was a significant difference between the two US groups in the percentages of malignancy, according to logistic regression analysis. Conclusion: Our results demonstrate that this system of US classification can efficiently differentiate malignant subcentimeter nodules from benign nodules. Suspicious sonographic features can be useful criteria to decide whether a nodule should receive FNAB.

AB - Background: Ultrasonography (US) is increasingly able to detect thyroid nodules, and the differentiation between malignant and benign nodules has been raising issues among both clinicians and patients, especially patients with non-palpable small nodules. It is important to diagnose thyroid cancer at an early stage, because it may reduce the risk of disease recurrence and possible mortality. Purpose: To evaluate the diagnostic accuracy of malignant sonographic features of subcentimeter thyroid nodules. Material and Methods: This study examined 815 subcentimeter thyroid nodules in 815 patients. A final diagnosis was determined using fine-needle aspiration biopsy (FNAB) or postoperative pathologic findings. Logistic regression tests were used to evaluate statistical relationships between US findings and thyroid carcinoma. Results: Of 534 lesions that showed suspicious US findings, 472 (88.4%) revealed malignancy upon cytopathology. Two hundred eighty-one lesions showed probably benign findings on US, and only 23 (8.2%) were malignant. Sensitivity, specificity, positive predictive value, and negative predictive value of US were 95.4%, 80.6%, 88.4%, and 91.8%, respectively. There was a significant difference between the two US groups in the percentages of malignancy, according to logistic regression analysis. Conclusion: Our results demonstrate that this system of US classification can efficiently differentiate malignant subcentimeter nodules from benign nodules. Suspicious sonographic features can be useful criteria to decide whether a nodule should receive FNAB.

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