Significant association of coronary stent fracture with in-stent restenosis in sirolimus-eluting stents

Jung Sun Kim, Seung Yul Lee, Myung Lee Jung, Won Yoon Young, Chul Min Ahn, Myung Hyun Kim, Pil Ki Min, Young Guk Ko, Bum Kee Hong, Donghoon Choi, Moon Kwon Hyuck, Yangsoo Jang, Won Heum Shim

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Abstract

Background: Several reports have suggested that stent fractures in sirolimus-eluting stents (SESs) might be related to in-stent restenosis (ISR). However, the role of stent strut fracture in ISR has not been clearly elucidated. Therefore, we investigated the association of the SES fracture and ISR. Methods: From 2003 to 2006, SES implantations with follow-up coronary angiography (CAG) for 628 lesions in 557 patients were analyzed. We reviewed clinical and procedural factors that might affect SES fracture and ISR. The median time interval from stent implantation to follow-up CAG was 9 months (range: 2-30 months). Results: ISR occurred in 38 patients (5.7%), and 21 stent fractures (3.3%) were identified by follow-up CAG. Fourteen cases occurred in the left anterior descending artery, and seven occurred in the right coronary artery. The binary ISR rate in the stent fracture group was higher compared with that of the nonfracture group (38.1% vs. 4.6%, P < 0.001). Predictors of ISR as estimated by multivariate analysis were a stent diameter less than 2.75 mm [odds ratio (OR) = 2.76, P = 0.012], a stent length over 28 mm (OR = 3.30, P = 0.024), and stent fracture (OR = 11.03, P < 0.001) after controlling for the angiographic and clinical risk factors of ISR. Conclusion: Stent fracture was an independent predictor of ISR and may be one of the crucial mechanisms of ISR after implantation of an SES.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalCoronary artery disease
Volume20
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Sirolimus
Stents
Coronary Angiography
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kim, J. S., Lee, S. Y., Jung, M. L., Young, W. Y., Ahn, C. M., Kim, M. H., ... Shim, W. H. (2009). Significant association of coronary stent fracture with in-stent restenosis in sirolimus-eluting stents. Coronary artery disease, 20(1), 59-63. https://doi.org/10.1097/MCA.0b013e32830fd101
Kim, Jung Sun ; Lee, Seung Yul ; Jung, Myung Lee ; Young, Won Yoon ; Ahn, Chul Min ; Kim, Myung Hyun ; Min, Pil Ki ; Ko, Young Guk ; Hong, Bum Kee ; Choi, Donghoon ; Hyuck, Moon Kwon ; Jang, Yangsoo ; Shim, Won Heum. / Significant association of coronary stent fracture with in-stent restenosis in sirolimus-eluting stents. In: Coronary artery disease. 2009 ; Vol. 20, No. 1. pp. 59-63.
@article{ff0912c3bcac40368feee22a7e9d9716,
title = "Significant association of coronary stent fracture with in-stent restenosis in sirolimus-eluting stents",
abstract = "Background: Several reports have suggested that stent fractures in sirolimus-eluting stents (SESs) might be related to in-stent restenosis (ISR). However, the role of stent strut fracture in ISR has not been clearly elucidated. Therefore, we investigated the association of the SES fracture and ISR. Methods: From 2003 to 2006, SES implantations with follow-up coronary angiography (CAG) for 628 lesions in 557 patients were analyzed. We reviewed clinical and procedural factors that might affect SES fracture and ISR. The median time interval from stent implantation to follow-up CAG was 9 months (range: 2-30 months). Results: ISR occurred in 38 patients (5.7{\%}), and 21 stent fractures (3.3{\%}) were identified by follow-up CAG. Fourteen cases occurred in the left anterior descending artery, and seven occurred in the right coronary artery. The binary ISR rate in the stent fracture group was higher compared with that of the nonfracture group (38.1{\%} vs. 4.6{\%}, P < 0.001). Predictors of ISR as estimated by multivariate analysis were a stent diameter less than 2.75 mm [odds ratio (OR) = 2.76, P = 0.012], a stent length over 28 mm (OR = 3.30, P = 0.024), and stent fracture (OR = 11.03, P < 0.001) after controlling for the angiographic and clinical risk factors of ISR. Conclusion: Stent fracture was an independent predictor of ISR and may be one of the crucial mechanisms of ISR after implantation of an SES.",
author = "Kim, {Jung Sun} and Lee, {Seung Yul} and Jung, {Myung Lee} and Young, {Won Yoon} and Ahn, {Chul Min} and Kim, {Myung Hyun} and Min, {Pil Ki} and Ko, {Young Guk} and Hong, {Bum Kee} and Donghoon Choi and Hyuck, {Moon Kwon} and Yangsoo Jang and Shim, {Won Heum}",
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Kim, JS, Lee, SY, Jung, ML, Young, WY, Ahn, CM, Kim, MH, Min, PK, Ko, YG, Hong, BK, Choi, D, Hyuck, MK, Jang, Y & Shim, WH 2009, 'Significant association of coronary stent fracture with in-stent restenosis in sirolimus-eluting stents', Coronary artery disease, vol. 20, no. 1, pp. 59-63. https://doi.org/10.1097/MCA.0b013e32830fd101

Significant association of coronary stent fracture with in-stent restenosis in sirolimus-eluting stents. / Kim, Jung Sun; Lee, Seung Yul; Jung, Myung Lee; Young, Won Yoon; Ahn, Chul Min; Kim, Myung Hyun; Min, Pil Ki; Ko, Young Guk; Hong, Bum Kee; Choi, Donghoon; Hyuck, Moon Kwon; Jang, Yangsoo; Shim, Won Heum.

In: Coronary artery disease, Vol. 20, No. 1, 01.01.2009, p. 59-63.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Significant association of coronary stent fracture with in-stent restenosis in sirolimus-eluting stents

AU - Kim, Jung Sun

AU - Lee, Seung Yul

AU - Jung, Myung Lee

AU - Young, Won Yoon

AU - Ahn, Chul Min

AU - Kim, Myung Hyun

AU - Min, Pil Ki

AU - Ko, Young Guk

AU - Hong, Bum Kee

AU - Choi, Donghoon

AU - Hyuck, Moon Kwon

AU - Jang, Yangsoo

AU - Shim, Won Heum

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Background: Several reports have suggested that stent fractures in sirolimus-eluting stents (SESs) might be related to in-stent restenosis (ISR). However, the role of stent strut fracture in ISR has not been clearly elucidated. Therefore, we investigated the association of the SES fracture and ISR. Methods: From 2003 to 2006, SES implantations with follow-up coronary angiography (CAG) for 628 lesions in 557 patients were analyzed. We reviewed clinical and procedural factors that might affect SES fracture and ISR. The median time interval from stent implantation to follow-up CAG was 9 months (range: 2-30 months). Results: ISR occurred in 38 patients (5.7%), and 21 stent fractures (3.3%) were identified by follow-up CAG. Fourteen cases occurred in the left anterior descending artery, and seven occurred in the right coronary artery. The binary ISR rate in the stent fracture group was higher compared with that of the nonfracture group (38.1% vs. 4.6%, P < 0.001). Predictors of ISR as estimated by multivariate analysis were a stent diameter less than 2.75 mm [odds ratio (OR) = 2.76, P = 0.012], a stent length over 28 mm (OR = 3.30, P = 0.024), and stent fracture (OR = 11.03, P < 0.001) after controlling for the angiographic and clinical risk factors of ISR. Conclusion: Stent fracture was an independent predictor of ISR and may be one of the crucial mechanisms of ISR after implantation of an SES.

AB - Background: Several reports have suggested that stent fractures in sirolimus-eluting stents (SESs) might be related to in-stent restenosis (ISR). However, the role of stent strut fracture in ISR has not been clearly elucidated. Therefore, we investigated the association of the SES fracture and ISR. Methods: From 2003 to 2006, SES implantations with follow-up coronary angiography (CAG) for 628 lesions in 557 patients were analyzed. We reviewed clinical and procedural factors that might affect SES fracture and ISR. The median time interval from stent implantation to follow-up CAG was 9 months (range: 2-30 months). Results: ISR occurred in 38 patients (5.7%), and 21 stent fractures (3.3%) were identified by follow-up CAG. Fourteen cases occurred in the left anterior descending artery, and seven occurred in the right coronary artery. The binary ISR rate in the stent fracture group was higher compared with that of the nonfracture group (38.1% vs. 4.6%, P < 0.001). Predictors of ISR as estimated by multivariate analysis were a stent diameter less than 2.75 mm [odds ratio (OR) = 2.76, P = 0.012], a stent length over 28 mm (OR = 3.30, P = 0.024), and stent fracture (OR = 11.03, P < 0.001) after controlling for the angiographic and clinical risk factors of ISR. Conclusion: Stent fracture was an independent predictor of ISR and may be one of the crucial mechanisms of ISR after implantation of an SES.

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U2 - 10.1097/MCA.0b013e32830fd101

DO - 10.1097/MCA.0b013e32830fd101

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AN - SCOPUS:58149260373

VL - 20

SP - 59

EP - 63

JO - Coronary Artery Disease

JF - Coronary Artery Disease

SN - 0954-6928

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