Silicon-based thiourea (SiliaBond® Thiourea) (Si-THU), a heterogeneous catalyst, has been applied to the highly selective C\-S bond formation via Michael addition of thiols to a,β-unsaturated carbonyl compounds under solvent-free conditions at 55-60°C. The thio-Michael addition products were obtained in an excellent yield under optimised conditions. This methodology involving a metal-free as well as a metal scavenger catalyst has been found to be an alternative method for the thio-Michael addition reaction.
Bibliographical noteFunding Information:
Acknowledgements. We gratefully acknowledge financial support from the Department of Science and Technology, Government of India (Grant No. SR/FTP/CS-99/2006). The authors are grateful to the VIT University management for their generous support and facilities. We also wish to thank the SAIF, IIT Madras, Chennai for providing the NMR and MS facility.
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)
- Industrial and Manufacturing Engineering
- Materials Chemistry