Simultaneous acquisition of perfusion and permeability from corrected relaxation rates with dynamic susceptibility contrast dual gradient echo

Eun Ju Kim, Dae Hong Kim, Sang Hoon Lee, yongmin Huh, Ho Taek Song, Jinsuck Suh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This study compared two methods, corrected (separation of T1 and T2 effects) and uncorrected, in order to determine the suitability of the perfusion and permeability measures through ΔR 2 and ΔR1 analyses. A dynamic susceptibility contrast dual gradient echo (DSC-DGE) was used to image the fixed phantoms and flow phantoms (Sephadex perfusion phantoms and dialyzer phantom for the permeability measurements). The results confirmed that the corrected relaxation rate was linearly proportional to gadolinium-diethyltriamine pentaacetic acid (Gd-DTPA) concentration, whereas the uncorrected relaxation rate did not in the fixed phantom and simulation experiments. For the perfusion measurements, it was found that the correction process was necessary not only for the ΔR1 time curve but also for the ΔR2 time curve analyses. Perfusion could not be measured without correcting the ΔR2 time curve. The water volume, which was expressed as the perfusion amount, was found to be closer to the theoretical value when using the corrected ΔR1 curve in the calculations. However, this may occur in the low concentration of Gd-DTPA in tissue used in this study. For the permeability measurements based on the two-compartment model, the permeability factor (kev; e = extravascular, v = vascular) from the outside to the inside of the hollow fibers was greater in the corrected ΔR 1 method than in the uncorrected ΔR1 method. The differences between the corrected and the uncorrected ΔR1 values were confirmed by the simulation experiments. In conclusion, this study proposes that the correction for the relaxation rates, ΔR2 and ΔR1, is indispensable in making accurate perfusion and permeability measurements, and that DSC-DGE is a useful method for obtaining information on perfusion and permeability, simultaneously.

Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalMagnetic Resonance Imaging
Volume22
Issue number3
DOIs
Publication statusPublished - 2004 Apr 1

Fingerprint

Permeability
Perfusion
Gadolinium
Acids
Experiments
Tissue
Fibers
Blood Vessels
Water

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Simultaneous acquisition of perfusion and permeability from corrected relaxation rates with dynamic susceptibility contrast dual gradient echo",
abstract = "This study compared two methods, corrected (separation of T1 and T2 effects) and uncorrected, in order to determine the suitability of the perfusion and permeability measures through ΔR 2 and ΔR1 analyses. A dynamic susceptibility contrast dual gradient echo (DSC-DGE) was used to image the fixed phantoms and flow phantoms (Sephadex perfusion phantoms and dialyzer phantom for the permeability measurements). The results confirmed that the corrected relaxation rate was linearly proportional to gadolinium-diethyltriamine pentaacetic acid (Gd-DTPA) concentration, whereas the uncorrected relaxation rate did not in the fixed phantom and simulation experiments. For the perfusion measurements, it was found that the correction process was necessary not only for the ΔR1 time curve but also for the ΔR2 time curve analyses. Perfusion could not be measured without correcting the ΔR2 time curve. The water volume, which was expressed as the perfusion amount, was found to be closer to the theoretical value when using the corrected ΔR1 curve in the calculations. However, this may occur in the low concentration of Gd-DTPA in tissue used in this study. For the permeability measurements based on the two-compartment model, the permeability factor (kev; e = extravascular, v = vascular) from the outside to the inside of the hollow fibers was greater in the corrected ΔR 1 method than in the uncorrected ΔR1 method. The differences between the corrected and the uncorrected ΔR1 values were confirmed by the simulation experiments. In conclusion, this study proposes that the correction for the relaxation rates, ΔR2 and ΔR1, is indispensable in making accurate perfusion and permeability measurements, and that DSC-DGE is a useful method for obtaining information on perfusion and permeability, simultaneously.",
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Simultaneous acquisition of perfusion and permeability from corrected relaxation rates with dynamic susceptibility contrast dual gradient echo. / Kim, Eun Ju; Kim, Dae Hong; Lee, Sang Hoon; Huh, yongmin; Song, Ho Taek; Suh, Jinsuck.

In: Magnetic Resonance Imaging, Vol. 22, No. 3, 01.04.2004, p. 307-314.

Research output: Contribution to journalArticle

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AU - Kim, Eun Ju

AU - Kim, Dae Hong

AU - Lee, Sang Hoon

AU - Huh, yongmin

AU - Song, Ho Taek

AU - Suh, Jinsuck

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