Simultaneous determination of gastrodin and gastrodigenin in gastrodia elata by HPLC-UV

Kyo Bin Kang, Jin Bum Jun, Guijae Yoo, Euna Kwon, Jun Won Yun, Byeong Cheol Kang, Seung Hyun Kim, Sang Hyun Sung, Young Pyo Jang, Heejung Yang

Research output: Contribution to journalArticle

Abstract

Gastrodia elata has been widely used as a traditional medicinal herb. However, in Korean Pharmacopeia, neither a marker constituent nor an analytical procedure for G. elata has been established. In this study, we suggest gastrodin and gastrodigenin as marker constituents of G. elata, and propose an analytical procedure for simultaneous quantification of these constituents by high-performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV). The analytical method was validated for its linearity, precision, accuracy, and specificity. Based on the validated method, gastrodin and gastrodigenin in 14 commercial G. elata samples were quantified.

Original languageEnglish
Pages (from-to)232-236
Number of pages5
JournalKorean Journal of Pharmacognosy
Volume48
Issue number3
Publication statusPublished - 2017 Jan 1

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Gastrodia
Spectrum Analysis
High Pressure Liquid Chromatography
Pharmacopoeias
Medicinal Plants
gastrodin
4-hydroxybenzyl alcohol

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Kang, K. B., Jun, J. B., Yoo, G., Kwon, E., Yun, J. W., Kang, B. C., ... Yang, H. (2017). Simultaneous determination of gastrodin and gastrodigenin in gastrodia elata by HPLC-UV. Korean Journal of Pharmacognosy, 48(3), 232-236.
Kang, Kyo Bin ; Jun, Jin Bum ; Yoo, Guijae ; Kwon, Euna ; Yun, Jun Won ; Kang, Byeong Cheol ; Kim, Seung Hyun ; Sung, Sang Hyun ; Jang, Young Pyo ; Yang, Heejung. / Simultaneous determination of gastrodin and gastrodigenin in gastrodia elata by HPLC-UV. In: Korean Journal of Pharmacognosy. 2017 ; Vol. 48, No. 3. pp. 232-236.
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Kang, KB, Jun, JB, Yoo, G, Kwon, E, Yun, JW, Kang, BC, Kim, SH, Sung, SH, Jang, YP & Yang, H 2017, 'Simultaneous determination of gastrodin and gastrodigenin in gastrodia elata by HPLC-UV', Korean Journal of Pharmacognosy, vol. 48, no. 3, pp. 232-236.

Simultaneous determination of gastrodin and gastrodigenin in gastrodia elata by HPLC-UV. / Kang, Kyo Bin; Jun, Jin Bum; Yoo, Guijae; Kwon, Euna; Yun, Jun Won; Kang, Byeong Cheol; Kim, Seung Hyun; Sung, Sang Hyun; Jang, Young Pyo; Yang, Heejung.

In: Korean Journal of Pharmacognosy, Vol. 48, No. 3, 01.01.2017, p. 232-236.

Research output: Contribution to journalArticle

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T1 - Simultaneous determination of gastrodin and gastrodigenin in gastrodia elata by HPLC-UV

AU - Kang, Kyo Bin

AU - Jun, Jin Bum

AU - Yoo, Guijae

AU - Kwon, Euna

AU - Yun, Jun Won

AU - Kang, Byeong Cheol

AU - Kim, Seung Hyun

AU - Sung, Sang Hyun

AU - Jang, Young Pyo

AU - Yang, Heejung

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N2 - Gastrodia elata has been widely used as a traditional medicinal herb. However, in Korean Pharmacopeia, neither a marker constituent nor an analytical procedure for G. elata has been established. In this study, we suggest gastrodin and gastrodigenin as marker constituents of G. elata, and propose an analytical procedure for simultaneous quantification of these constituents by high-performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV). The analytical method was validated for its linearity, precision, accuracy, and specificity. Based on the validated method, gastrodin and gastrodigenin in 14 commercial G. elata samples were quantified.

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Kang KB, Jun JB, Yoo G, Kwon E, Yun JW, Kang BC et al. Simultaneous determination of gastrodin and gastrodigenin in gastrodia elata by HPLC-UV. Korean Journal of Pharmacognosy. 2017 Jan 1;48(3):232-236.