Aim: To determine the histological outcomes when using a highly porous synthetic bone substitute and a cross-linked collagen membrane for lateral bone augmentation of peri-implant dehiscence defects. Methods: In eight dogs, three treatment groups were randomly allocated at each peri-implant dehiscence defect (mean height × depth = 3 × 1 mm) as follows: (i) synthetic bone substitute covered by a cross-linked collagen membrane (test group), (ii) deproteinized bovine bone mineral covered by a natural collagen membrane (positive control), and (iii) no treatment (negative control). Two healing periods (8 and 16 weeks) were applied. Results: The differences in healing outcomes between the test and positive control groups were not significant at 8 weeks. Horizontal bone augmentation 2 mm below the implant shoulder was significantly greater in the test group (1.22 ± 0.53 mm) than in the positive and negative controls (0.42 ± 0.51 and 0.36 ± 0.50 mm, respectively) at 16 weeks. Similarly, the augmented tissue thickness at 0, 1, and 2 mm apical to the implant shoulder was significantly greater in the test group than in the positive control group. Conclusion: The test group showed significantly better histological outcomes for lateral bone augmentation and tissue thickness at 16 weeks compared to both the positive and negative control groups.
Bibliographical noteFunding Information:
This study was partially funded through a research contract between Dentium and the University Complutense of Madrid.
We thank Dentium and Genoss for providing the dental implants and regenerative materials used in this investigation. We are also grateful for the financial support through a research contract between Dentium and the University Complutense of Madrid. We thank Drs Sung-Min Chung, Fernando Luengo, Rafael Pla, and Ricardo Di Raimondo for their active participation in the experimental surgical procedures. We thank the veterinary doctors Maria C. Calles and Elena Abellan, as well as personnel from the Minimally Invasive Surgery Centre, Caceres, Spain, who so effectively took care of the experimental animals used in this investigation.
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