Single Administration of a Biodegradable, Separable Microneedle Can Substitute for Repeated Application of Eyedrops in the Treatment of Infectious Keratitis

Seung Hyun Park, Kang Ju Lee, Heekyoung Kang, Ye Jin Lee, Ji Yong Lee, Jeong Hun Kim, Hyun Beom Song, Won Hyoung Ryu

Research output: Contribution to journalArticlepeer-review

Abstract

Infectious keratitis is mainly treated with topical antibiotics. To achieve and maintain the required therapeutic concentration in the cornea where the tear fluid continuously rinses the surface, the antibiotics must be frequently applied, even while the patient is sleeping, and oral medication is sometimes required. However, the inevitably poor compliance and avascular nature of the cornea decrease drug bioavailability. In this study, a single microneedle (MN) is injected into the cornea to substitute for the repeated application of eyedrops in the treatment of infectious keratitis. After comparing the mechanical integrity and drug release profiles of three different drug-tips, the drug-tip with the “high” drug concentration that releases 12.5 ng drug within 3 days is applied to a cornea to evaluate the transferability and in vivo drug release. In the treatment of infectious keratitis with repeated application of eyedrops for six consecutive days, a single MN injection is substituted for the initial 3 days of eyedrop applications. The progression remains similarly attenuated after 3 days without eyedrops, and comparable efficacy is achieved on day 6 when combined with delayed eyedrop treatment from day 3. Thus, the single administration of a biodegradable MN can substitute for the repeated application of eyedrops in the treatment of infectious keratitis.

Original languageEnglish
Article number2002287
JournalAdvanced Healthcare Materials
Volume10
Issue number11
DOIs
Publication statusPublished - 2021 Jun 9

Bibliographical note

Funding Information:
S.P., K.J.L., and H.K. contributed equally to this work. This work was supported by Grant No. 04‐2018‐0380 from the SNUH Research Fund, Research Resettlement Fund for the new faculty of Seoul National University, the National Research Foundation of Korea (NRF) Grant funded by the Ministry of Science and ICT (MSIT) (2015R1A5A1037668), and Global Infrastructure Program through the NRF funded by the MSIT (2019K1A3A1A18116048).

Publisher Copyright:
© 2021 Wiley-VCH GmbH

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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